A5085641546- Dermatology and Skin Diseases
- Food Allergy and Anaphylaxis Research
- Allergic Rhinitis and Sensitization
- Sphingolipid Metabolism and Signaling
- Urticaria and Related Conditions
- Contact Dermatitis and Allergies
- Asthma and respiratory diseases
- Erythrocyte Function and Pathophysiology
- Exercise and Physiological Responses
- Cellular Mechanics and Interactions
- Pharmacological Effects of Natural Compounds
- Fatty Acid Research and Health
- Neonatal skin health care
- Fibroblast Growth Factor Research
- Psoriasis: Treatment and Pathogenesis
- Transgenic Plants and Applications
- IL-33, ST2, and ILC Pathways
- Adrenal Hormones and Disorders
- Stress Responses and Cortisol
- Autophagy in Disease and Therapy
- Skin and Cellular Biology Research
- Advancements in Transdermal Drug Delivery
National Jewish Health
2019-2025
University of Colorado Denver
2019-2025
Abstract Background Atopic dermatitis (AD) is characterized by abnormal skin lipids that are largely driven hyperactivated type 2 immune responses. The antibody to the α‐subunit of interleukin (IL)‐4 receptor, dupilumab, was recently approved treat AD and demonstrated strong efficacy. However, role dupilumab therapy in regulation barrier structure function has not been fully explored. Methods We have evaluated content transepidermal water loss (TEWL) lesional non‐lesional adults adolescents...
Abstract Background Staphylococcus ( S ) aureus colonization is known to cause skin barrier disruption in atopic dermatitis (AD) patients. However, it has not been studied how . induces aberrant epidermal lipid composition and dysfunction. Methods Skin tape strips (STS) swabs were obtained from 24 children with AD (6.0 ± 4.4 years) 16 healthy (7.0 4.5 years). Lipidomic analysis of STS samples was performed by mass spectrometry. levels methicillin‐sensitive methicillin‐resistant (MSSA MRSA)...
The loss of pulmonary endothelial cells in emphysema is associated with increased lung ceramide. Ceramide perturbations may cause adaptive alterations other bioactive sphingolipids, pathogenic implications. We previously reported a negative correlation between and circulating glycosphingolipids (GSLs). Glucosylceramide (GlcCer), the initial GSL synthesized from ceramide by GCS (GlcCer synthase), required for embryonic survival, but its role unknown.
Skin sphingolipids are unique and fulfill the important task of forming a hydrophobic barrier to limit water loss from body but also protect allergen, bacterial viral penetration through skin. highly diverse in their combination fatty acids sphingoid bases, presence ω‐esterified ceramides (EOS‐CER), abundance ultra long‐chain (ULCFA, up C36) within ceramide molecules. The chain length bases is commonly attributed C18 molecules there only few reports demonstrating C20‐ C22‐sphingoid skin...
Rationale Atopic dermatitis (AD) with eczema herpeticum (EH) can result in systemic infections and be life‐threatening. The purpose of this study was to identify differences non‐lesional skin between AD a history recurrent EH (ADEH+), without (ADEH−), non‐atopic (NA) controls gain insight into mechanisms involved pathogenesis using novel minimally invasive tape strip (STS) methodology mass spectrometric approaches. Methods STS layers 5–6 from 13 NA, ADEH−, 15 ADEH+ adult subjects were...
Background: Atopic dermatitis (AD), or atopic eczema, commonly occurs in children and can progress into severe phenotype march, causing significant impairment quality of life. To prevent the development AD, it is important to find early biomarkers predict future onset AD before any clinical manifestations.Methods: Newborns (n=111) with without family history diseases (risk group, n=74 control n=37) were enrolled Seoul, Korea. Skin tape strips (STS) collected from volar area forearm at age 2...