A5017496757- Cardiovascular Effects of Exercise
- Cardiac Imaging and Diagnostics
- Cardiac, Anesthesia and Surgical Outcomes
- Acute Myocardial Infarction Research
- Atrial Fibrillation Management and Outcomes
- Cardiovascular and exercise physiology
- Cardiac pacing and defibrillation studies
- Cardiomyopathy and Myosin Studies
- Infective Endocarditis Diagnosis and Management
- Cardiovascular Disease and Adiposity
- Hemodynamic Monitoring and Therapy
- Cardiovascular Health and Disease Prevention
- Cardiac Arrest and Resuscitation
- Cardiac Health and Mental Health
- Cardiac electrophysiology and arrhythmias
- Coronary Interventions and Diagnostics
- Blood Pressure and Hypertension Studies
- Sports injuries and prevention
- COVID-19 and healthcare impacts
- Fibroblast Growth Factor Research
- Cardiovascular Function and Risk Factors
- Tracheal and airway disorders
- Lipoproteins and Cardiovascular Health
- Cancer-related gene regulation
- Dental Health and Care Utilization
Geisinger Health System
2016-2024
Geisinger Wyoming Valley Medical Center
2016-2024
Valley Hospital
2020-2022
Aultman Hospital
2022
Geisinger Neuroscience Institute
2020
Geisinger Medical Center
2016
Lehigh Valley Hospital-Pocono
2008-2015
Lehigh Valley Health Network
2010-2015
Health Net
2010-2011
Pennsylvania State University
2008-2011
Hepatoma-derived growth factor (HDGF) is the first member identified of a new family secreted heparin-binding factors highly expressed in fetal aorta. The biologic role HDGF vascular unknown. Here, we demonstrate that mRNA smooth muscle cells (SMCs), most prominently proliferating SMCs, 8–24 hours after serum stimulation. Exogenous and endogenous overexpression stimulated significant increase SMC number DNA synthesis. Rat aortic SMCs transfected with hemagglutinin-epitope–tagged rat cDNA...
Background: The relationship between breast artery calcification (BAC) noted on mammography and both coronary disease cardiovascular risk remains controversial. Few studies have examined the clinical significance of BAC in asymptomatic women. In present study we evaluated calcium (CAC) as identified by multi-slice CT scanning (MSCT). Patients methods: Consecutive women (n = 98) with routine but without known (CAD) were assessed for CAD factors had assessment MSCT. A control cohort...
Smooth muscle cell (SMC) proliferation plays a key role in vascular proliferative disorders. The molecular mechanisms that control cycle entry of SMCs response to injury are not well understood. Id2 (inhibitor DNA binding) is member the helix-loop-helix (HLH) family transcription regulators known promote progression. Thus, we investigated SMC growth and regulation. results demonstrated overexpression resulted significant enhancement via increased S-phase entry. A possible mechanism...
Background: Genomic screening holds great promise for presymptomatic identification of hidden disease, and prevention dramatic events, including sudden cardiac death associated with arrhythmogenic cardiomyopathy (ACM). Herein, we present findings from clinical follow-up carriers ACM-associated pathogenic/likely pathogenic desmosome variants ascertained through genomic screening. Methods: Of 64 548 eligible participants in Geisinger MyCode Screening Counseling program (2015–present), 92...
Abstract —The molecular mechanisms that regulate the proliferation of smooth muscle cells (SMCs) vasculature in response to injury are poorly understood. Members inhibitor DNA binding (Id) class helix-loop-helix transcription factors known growth a variety cell types; however, expression various Id genes SMCs and vascular lesions has not been examined. In present study, yeast 2-hybrid system was used clone from cultured rat aortic SMC library. By use ubiquitous E proteins as bait, Id3 novel...
Background Political orientation may play a formative role in perceptions of risk associated with COVID-19 vaccination including vaccine myocarditis (CVM). Whether political alignment news sources plays perception this is unknown. Objective We examined the relationship between online media sites and aspects reporting CVM. Methods Media were classified as “left” or “right" biased using Allsides bias rating report. For each site “COVID myocarditis” was searched articles posted May 2021 to...
The Framingham Risk Score (FRS) has become the standard tool to determine coronary heart disease (CHD) risk. Recent studies have demonstrated that FRS underestimates CHD risk in a number of patient populations. One strategy been proposed improve diagnostic accuracy is use imaging subclinical atherosclerosis define "vascular age" and this age calculate FRS. Both computed tomography assessment artery calcium (CAC) ultrasonographic carotid intima-media thickness (CIMT) as modalities can be...
NA variants that are expected to confer risk for arrhythmogenic right ventricular cardiomyopathy (ARVC) recommended as returnable secondary findings from clinical genomic sequencing.However, ARVC presents several distinct challenges the care and management of patients ascertained through this genome-first approach.We discuss these present recent cases exemplify their impact in a setting.We also propose standard approach evaluations surveillance finally potential diagnostic innovations may...
Objective: To determine the effect of training intensity on thyroid function among female nonelite runners. Design: Internet-based survey medical history and racing habits Participants: A total 1222 runners aged ≥35 years. Main Outcome Measures: Self-reported diagnosis hypothyroidism details racing. Results: Hypothyroidism was reported by 149 (12.2%). No characteristics or duration, including average miles per week, pace, years accumulated running were associated with dysfunction. Females...
Patients who suffer a first ST ‐elevation myocardial infarction ( STEMI ) typically have fewer identifiable risk factors than those other types of acute coronary syndromes. As such, assessment tools such as the Framingham Risk Score FRS often fail to classify these patients high risk. In this study, we tested ability carotid intima‐media thickness CIMT enhance identify are at for , using ‐derived “vascular age” in place chronologic age calculation . We applied ‐based vascular cohort...
Despite robust growth in participation marathons and endurance sports among older individuals, guidance regarding pre-participation cardiovascular evaluation of these athletes is lacking. The objective this study was to assess the utility currently available guidelines as applied a cohort novice athletes.We data from 1457 runners aged 35 years two screening tools, American Heart Association/American College Sports Medicine Pre-Participation Questionnaire 2001 Working Group recommendations...
The COVID-19 pandemic has had a profound effect on all aspects of life, including physical fitness and well-being the general population. In present study, we assessed subjective objective high-level nonelite runners.The MASTERS Athletic Study is an ongoing survey training health habits runners, majority whom compete in marathons other extreme endurance events. We invited participants to web-based questionnaire regarding during pandemic. Comparisons were made between as well relationship...