A5038507335- T-cell and B-cell Immunology
- Single-cell and spatial transcriptomics
- Immune Cell Function and Interaction
- vaccines and immunoinformatics approaches
- Immunodeficiency and Autoimmune Disorders
- Lymphoma Diagnosis and Treatment
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Monoclonal and Polyclonal Antibodies Research
Yale University
2022-2024
Abstract In adaptive immune receptor repertoire analysis, determining the germline variable (V) allele associated with each T- and B-cell sequence is a crucial step. This process highly impacted by annotations. Aligning sequences, assigning them to specific alleles, inferring individual genotypes are challenging when mutated, or reads do not cover whole V region. Here, we propose an alternative naming scheme for as well novel method infer genotypes. We demonstrate strengths of two comparing...
Adaptive Immune Receptor Repertoire sequencing (AIRR-seq) is a valuable experimental tool to study the immune state in health and following challenges such as infectious diseases, (auto)immune cancer. Several tools have been developed reconstruct B cell T receptor sequences from AIRR-seq data infer clonal relationships. However, currently available offer limited parallelization across samples, scalability or portability high-performance computing infrastructures. To address this need, we...
Abstract In adaptive immune receptor repertoire analysis, determining the germline variable (V) allele associated with each T- and B-cell sequence is a crucial step. This process highly impacted by annotations. Aligning sequences, assigning them to specific alleles, inferring individual genotypes are challenging when mutated, or reads do not cover whole V region. Here, we propose an alternative naming scheme for alleles as well novel method infer genotypes. We demonstrate strength of two...
ABSTRACT Adaptive Immune Receptor Repertoire sequencing (AIRR-seq) is a valuable experimental tool to study the immune state in health and following challenges such as infectious diseases, (auto)immune cancer. Several tools have been developed reconstruct B cell T receptor sequences from AIRR-seq data infer clonal relationships. However, currently available offer limited parallelization across samples, scalability or portability high-performance computing infrastructures. To address this...