A5055273520- Immune Response and Inflammation
- Oral microbiology and periodontitis research
- Extracellular vesicles in disease
- MicroRNA in disease regulation
- T-cell and B-cell Immunology
- Circular RNAs in diseases
- Genomics, phytochemicals, and oxidative stress
- Advancements in Transdermal Drug Delivery
- Adenosine and Purinergic Signaling
- Oral Health Pathology and Treatment
- Selenium in Biological Systems
- Ocular Surface and Contact Lens
- HIV/AIDS oral health manifestations
- Peptidase Inhibition and Analysis
- RNA Interference and Gene Delivery
- Rabies epidemiology and control
- Curcumin's Biomedical Applications
- Biochemical and Molecular Research
- Pharmacological Effects of Natural Compounds
- Dermatology and Skin Diseases
- Adipokines, Inflammation, and Metabolic Diseases
- Streptococcal Infections and Treatments
- Dental Health and Care Utilization
- Inflammation biomarkers and pathways
University of Kentucky
2020-2024
Instituto Butantan
2016-2018
Abstract Background The aim of the present study was to evaluate subgingival microbiome in patients with grade C molar‐incisor pattern periodontitis (C‐MIP) affecting primary or permanent dentitions. Methods DNA isolated from biofilm samples diseased and healthy sites 45 C‐MIP subjected phylogenetic microarray analysis. were compared between children affected those Within‐subject differences C‐MIP‐affected dentition‐matched also evaluated. Results subjects dentition showed partially...
This study aimed to compare microbial and inflammatory profiles in periodontally/systemically healthy African American (AA) Caucasian (C) individuals.
Abstract Aim Previous data from our laboratory have demonstrated that localized aggressive periodontitis (LAP) patients produce elevated levels of pro‐inflammatory cytokines in response to TLR4 and TLR2 ligation compared unrelated periodontally healthy controls (HC). The aim the present work is evaluate contribution TLR‐related gene expression miRNA regulation LAP disease. Material methods Peripheral blood mononuclear cells (PBMCs) health control (HC) were isolated. Gene involved TLR...
Introduction Periodontitis is an immune-mediated inflammatory disease affecting almost half of the adult population and leading cause tooth loss in United States. The role extracellular nucleotide signaling including metabolizing enzyme CD73 adds important layer interaction purine mediators capable orchestrating outcomes. able to catabolize 5′-adenosine monophosphate into adenosine at level, playing a critical regulating many processes under physiological pathological conditions. Here, we...
Mouse lines selected for maximal (AIRmax) or minimal acute inflammatory reaction (AIRmin) were used to characterize the immune response and influence of genetic background during pristane-induced arthritis (PIA). Susceptible AIRmax mice demonstrated exacerbated cellular profiles PIA, with intense infiltration lymphocytes, as well monocytes/macrophages neutrophils, producing higher levels IL-1 β , IFN- γ TNF- α IL-10, total IgG3, chemokines. Resistant AIRmin controlled cell activation more...
Pristane-induced arthritis (PIA) in mice is an experimental model that resembles human rheumatoid arthritis, a chronic autoimmune disease affects joints and characterized by synovial inflammation articular cartilage bone destruction. AIRmax AIRmin mouse lines differ their susceptibility to PIA, linkage analysis this mapped severity QTLs chromosomes 5 8. miRNAs are class of small RNA molecules have been extensively studied the development arthritis. We analyzed miRNA gene expression profiles...