A5080854084- Epigenetics and DNA Methylation
- Blood Coagulation and Thrombosis Mechanisms
- Cancer-related Molecular Pathways
- Cancer Cells and Metastasis
- Systemic Lupus Erythematosus Research
- Phagocytosis and Immune Regulation
- Wnt/β-catenin signaling in development and cancer
- Hedgehog Signaling Pathway Studies
Johannes Gutenberg University Mainz
2014-2021
Praxis für Humangenetik
2021
University Medical Center of the Johannes Gutenberg University Mainz
2016-2021
A lipid-protein autoimmunity target Several autoimmune diseases, including systemic lupus erythematosus and primary antiphospholipid syndrome, are characterized by the presence of antibodies (aPLs). These molecules can activate complement coagulation cascades, which contributes to pathologies such as thrombosis, stroke, pregnancy complications. Müller-Calleja et al. found that endothelial protein C receptor (EPCR) in complex with lysobisphosphatidic acid (LBPA) is cell-surface for aPL...
Constitutive epimutations of tumor suppressor genes are increasingly considered as cancer predisposing factors equally to sequence mutations. In light the emerging role microenvironment for predisposition, initiation, and progression, we aimed characterize consequences a BRCA1 epimutation in cells mesenchymal origin. We performed comprehensive molecular cellular comparison primary dermal fibroblasts taken from monozygous twin pair discordant recurrent cancers epimutation, whose exceptional...