A5082276988- Parasites and Host Interactions
- Child Nutrition and Water Access
- Global Maternal and Child Health
- Parasite Biology and Host Interactions
- Helminth infection and control
- Parasitic Infections and Diagnostics
- Parasitic Diseases Research and Treatment
- Iron Metabolism and Disorders
- Zoonotic diseases and public health
- Pharmacogenetics and Drug Metabolism
- Diabetes Treatment and Management
- Pancreatic function and diabetes
- Global Health and Surgery
- Therapeutic Uses of Natural Elements
- Environmental DNA in Biodiversity Studies
- Hemoglobinopathies and Related Disorders
- Insect-Plant Interactions and Control
- Pharmaceutical and Antibiotic Environmental Impacts
- Freshwater macroinvertebrate diversity and ecology
- Tumors and Oncological Cases
- Mosquito-borne diseases and control
- Forest Insect Ecology and Management
- Malaria Research and Control
- Trace Elements in Health
- Organ Transplantation Techniques and Outcomes
Oslo University Hospital
2023
Novo Nordisk (Denmark)
1997-2022
University of Copenhagen
2012-2021
National Institute for Medical Research
2015
Centre for Research and Development
2008-2012
Anglian Water Services (United Kingdom)
2003-2009
Ministry of Health
2008
Danish Centre for Marine Research
1997-2006
Human Sciences Research Council
2005
University of KwaZulu-Natal
2005
Pharmacological strategies that engage multiple mechanisms-of-action have demonstrated synergistic benefits for metabolic disease in preclinical models. One approach, concurrent activation of the glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic peptide (GIP), and glucagon (Gcg) receptors (i.e. triagonism), combines anorectic activities GLP-1 GIP with energy expenditure effect glucagon. While efficacy triagonism models is known, relative contribution GcgR remains unassessed....
Liraglutide is a novel once-daily human glucagon-like peptide (GLP)-1 analog in clinical use for the treatment of type 2 diabetes. To study metabolism and excretion [<sup>3</sup>H]liraglutide, single subcutaneous dose 0.75 mg/14.2 MBq was given to healthy males. The recovered radioactivity blood, urine, feces measured, metabolites were profiled. In addition, [<sup>3</sup>H]liraglutide [<sup>3</sup>H]GLP-1(7–37) incubated vitro with dipeptidyl peptidase-IV (DPP-IV) neutral endopeptidase (NEP)...
SUMMARY Beginning in 1970, the potential of remote sensing (RS) techniques, coupled with geographical information systems (GIS), to improve our understanding epidemiology and control schistosomiasis Africa, has steadily grown. In current review, working definitions RS, GIS spatial analysis are given, applications made date RS for ecology Africa summarised. Progress been mapping prevalence infection humans distribution intermediate host snails. More recently, Bayesian geostatistical modelling...
Significance Accurate detection and delineation of schistosomiasis transmission sites will be vital in ongoing efforts to control ultimately eliminate one the most neglected tropical parasitic diseases affecting >250 million people worldwide. Conventional methods detect parasites environment are cumbersome have low sensitivity. We therefore developed an environmental DNA (eDNA)-based method for schistosome aquatic environments. Aquatic eDNA showed higher sensitivity than conventional...
Preventive chemotherapy with praziquantel for schistosomiasis morbidity control is commonly done by mass drug administration (MDA). MDA regimen usually based on prevalence in a given area, and effectiveness evaluated decreases and/or intensity of infection after several years implementation. Multiple studies programs now find that even within well-implemented, multiyear, annual there often remain locations do not decline to expected levels. We term such “persistent hotspots.” To study...
Journal Article Epidemiology of helminth infections and their relationship to clinical malaria in southwest Uganda Get access Adrienne E. Shapiro, Shapiro aLondon School Hygiene Tropical Medicine, Keppel Street, London WC1E 7HT, UK Search for other works by this author on: Oxford Academic PubMed Google Scholar Edridah M. Tukahebwa, Tukahebwa bVector Control Division, Ministry Health, Kampala, P.O. Box 1661, Jennifer Kasten, Kasten Siân Clarke, Clarke Pascal Magnussen, Magnussen cDanish...
Control of schistosomiasis presently relies largely on preventive chemotherapy with praziquantel through mass drug administration (MDA) programs. The Schistosomiasis Consortium for Operational Research and Evaluation has concluded five studies in four countries (Côte d’Ivoire, Kenya, Mozambique, Tanzania) to evaluate alternative approaches MDA. Studies involved intervention years, final evaluation the fifth year. Mass given annually or twice over 4 years reduced average prevalence intensity...
A cross-sectional study of 729 children and adults in western Kenya investigated the impact infection with hookworm, Ascaris lumbricoides, Trichuris trichiura, Schistosoma mansoni malaria on iron status. In bivariate analyses, hookworm intensities as low 300 eggs/g faeces were negatively related to levels haemoglobin (Hb) serum ferritin (SF). Malaria parasitaemia was Hb positively SF, while S. SF. Multivariate regression analysis done identify predictors SF levels. children, age (in years)...
Geophagy has been associated with iron deficiency and anaemia, but no causal relationship established. To clarify this, we conducted a two-by-two factorial randomised, controlled trial on the effect of multimicronutrient supplementation geophagy in Zambian schoolchildren Lusaka, from February to December 2001. Of 406 children, 212 (52.2%) were girls mean (range) age was 10.2 (7-15) years. reported by 302 (74.4%) more often than boys (80.2 vs. 67.7%, P = 0.007). The daily earth intake 25.2...
Schistosomiasis is one of the major health problems in tropical and sub-tropical countries, with school age children usually being most affected group. In 1998 Department Health province KwaZulu-Natal established a pilot programme for helminth control that aimed at regularly treating primary schistosome intestinal infections. This article describes baseline situation impact treatment on S. haematobium infection cohort schoolchildren attending grade 3 rural part province.Primary from...
A randomized open-label trial, including 834 pregnant women, examined efficacy and recorded adverse events of ivermectin (ivc) albendazole (alb) alone combined (comb) on soil-transmitted helminth infections (STHs) in the second trimester pregnancy. One abortion occurred alb group 10 stillbirths (1, 5, 3, 1) ivc, alb, comb, reference (ref) with no STHs, respectively. Two babies were born congenital abnormalities (1 [ivc] 1 [ref]). The prevalence anemia at first antenatal care (ANC) visit was...
Background In Uganda, the current national health sector strategic and investment plan underscores schistosomiasis as one of diseases targeted for elimination by year 2015. However, uptake treatment among school children is unknown but suspected to be low. We estimated predictors preventive with praziquantel. Methods a cross sectional study carried out in Jinja district random sample 1,010 12 primary schools was questioned about their praziquantel, knowledge perceptions schistosomiasis,...
The Schistosomiasis Consortium for Operational Research and Evaluation (SCORE) was established in 2008 to answer strategic questions about schistosomiasis control. For programme managers, a high-priority question is: what are the most cost-effective strategies delivering preventive chemotherapy (PCT) with praziquantel (PZQ)? This paper describes process SCORE used transform this into harmonized research protocol, study design answering question, village eligibility assessments data resulting...
This report summarizes the design and outcomes of randomized controlled operational research trials performed by Bill & Melinda Gates Foundation-funded Schistosomiasis Consortium for Operational Research Evaluation (SCORE) from 2009 to 2019. Their goal was define effectiveness test limitations current WHO-recommended schistosomiasis control protocols performing large-scale pragmatic compare impact different schedules coverage regimens praziquantel mass drug administration (MDA). Although...