A5024424274- Hemoglobinopathies and Related Disorders
- Pharmacological Effects and Toxicity Studies
- Iron Metabolism and Disorders
- Vitamin D Research Studies
- Blood groups and transfusion
- Childhood Cancer Survivors' Quality of Life
- Prenatal Screening and Diagnostics
- Bone and Joint Diseases
- Chronic Disease Management Strategies
- Telemedicine and Telehealth Implementation
- Adolescent and Pediatric Healthcare
- Acute Lymphoblastic Leukemia research
- Fungal Infections and Studies
- Neurological and metabolic disorders
- Erythrocyte Function and Pathophysiology
- Mobile Health and mHealth Applications
- Pharmacogenetics and Drug Metabolism
- Epilepsy research and treatment
- Cardiac Arrest and Resuscitation
- Mosquito-borne diseases and control
- Genomics and Rare Diseases
- Antifungal resistance and susceptibility
- Cystic Fibrosis Research Advances
- Acute Myeloid Leukemia Research
- Venous Thromboembolism Diagnosis and Management
Novo Nordisk (United Kingdom)
2024
Levine Cancer Institute
2016-2021
Center for Cancer and Blood Disorders
2011-2020
Emory University
2007-2020
Carolinas Healthcare System
2015-2018
Children's Healthcare of Atlanta
2007-2014
Aflac (United States)
2011-2013
Palmetto Hematology Oncology
2013
Georgia State University
2012
Morgan Stanley Children's Hospital
2008
Oxidative stress contributes to the complex pathophysiology of sickle cell disease. Oral therapy with pharmaceutical-grade l-glutamine (USAN, glutamine) has been shown increase proportion reduced form nicotinamide adenine dinucleotides in erythrocytes, which probably reduces oxidative and could result fewer episodes cell–related pain.
Sickle cell nephropathy begins in childhood and may progress to renal failure. Albuminuria is a sensitive marker of glomerular damage that indicate early chronic kidney disease (CKD).The aims this study were determine the cross-sectional prevalence clinical correlates albuminuria CKD among children with sickle (SCD). Over 10-year period (1995 2005) 410 pediatric SCD patients ages 2 21 years enrolled: 261 hemoglobin SS (HbSS) or HbSβ(0) thalassemia (HbSβ(0)) 149 HbSC HbSβ(+) (HbSβ(+)). The...
Background Health systems and providers across America are increasingly employing telehealth technologies to better serve medically underserved low-income, minority, rural populations at the highest risk for health disparities. The Patient-Centered Outcomes Research Institute (PCORI) has invested US $386 million in comparative effectiveness research telehealth, yet little is known about key early lessons garnered from this regarding best practices using address Objective This paper describes...
Transition of young adults with sickle cell disease (SCD) from pediatric to adult medical care is an important priority, given advances that have transformed SCD into a lifelong chronic condition, rather than childhood. Successful transfer has its foundation in collaboration among the adult, family, and health system support building skills positive management independent living. Systemic issues transition for individuals include limited access providers and/or interest caring people SCD;...
Summary We tested the hypothesis that extracellular haem is linked to incidence of acute complications sickle cell disease ( SCD ). Using multivariable regression analysis, higher plasma free haem, but not total was associated with increased odds vaso‐occlusive crisis VOC ) [ P = 0·028, ratio OR ); 2·05, 95% Confidence Interval CI 1·08–3·89] and chest syndrome ACS 0·016, ; 2·56, 1·19, 5·47], after adjusting for age gender in children . These findings suggest factors influence its...
We report results of a pilot study high-dose vitamin D in sickle cell disease (SCD). Subjects were given 6-week course oral cholecalciferol (4000-100 000 IU per week) or placebo and monitored prospectively for period six months. Vitamin insufficiency deficiency was present at baseline 82·5% 52·5% subjects, respectively. who received achieved higher serum 25-hydroxyvitamin D, experienced fewer pain days week, had physical activity quality-of-life scores. These findings suggest potential...
The hallmark of sickle cell disease (SCD) is pain from a vaso-occlusive crisis. Although ambulatory accounts for most days in pain, also the common cause hospitalization and typically treated with parenteral opioids. evidence base lacking analgesic practice SCD, particularly optimal opioid dosing patient-controlled analgesia (PCA), part because challenges trial design conduct this rare disease.The purpose report to describe our Network's experiences protocol development, implementation,...
Abstract Background Invasive mold infections (IMI) are a leading cause of infectious mortality in allogeneic stem cell transplant (AlloSCT) recipients. Fluconazole, the current standard for fungal prophylaxis, is ineffective against molds. We initiated pilot study to determine safety and activity prophylactic liposomal amphotericin B (AMB) preventing IMI pediatric adolescent AlloSCT recipients during first 100 days. Procedure Fifty‐one patients (57 AlloSCT) were given AMB (3 mg/kg/day)...
Summary ‘Paradoxical’ embolization via intracardiac or intrapulmonary right‐to‐left shunts ( RLS ) is an established cause of stroke. Hypercoagulable states and increased right heart pressure, which both occur in sickle cell anaemia SCA ), predispose to paradoxical embolization. We hypothesized that children with overt stroke + stroke) have prevalence potential . performed contrasted transthoracic echocardiograms on 147 (aged 2–19 years) mean age 12·7 ± 4·8 years, 54·4% male) a control group...
The opioid medications codeine and hydrocodone, commonly prescribed in sickle cell disease (SCD), require metabolic conversion by cytochrome P450 2D6 (CYP2D6) to morphine hydromorphone, respectively, exert their analgesic effects. CYP2D6 gene is highly polymorphic, with variant alleles that result decreased, absent, or ultrarapid enzyme activity. Seventy-five children SCD were tested for polymorphisms, phenotypes inferred from the genotypes. most common CYP2D6*2 (normal activity, 28.7%),...
The prevalence of cerebrovascular events in sickle cell disease (SCD) can be as low 10% by the age 18 for overt cerebral infarction or strokes, up to 35% silent infarction, and high 43/100 patient years acute ischemic events. These typically occur during childhood with a peak incidence between 4 7 years. cumulative risk central nervous system SCD increases age. Transcranial Doppler (TCD) ultrasonography is an established screening tool detecting children at highest stroke measuring flow...
Clinical features of a case finger and toe nail infection due to Hendersonula toruloidea the characteristics isolate are described. The was sensitive clotrimazole at concentration 10 micrograms ml-1. patient responded well topical application lotion this antimycotic.
Abstract Background Abnormalities in bone mineral density (BMD) occur children treated for acute lymphoblastic leukemia (ALL). However, BMD estimates have been performed using varied instruments, reference data, and interpretations. This exploratory cross sectional study to evaluate mass with ALL, uses an algorithm that serially adjusts variables known affect pediatric measures by dual energy X‐ray absorptiometry (DXA), based on models developed 1,218 healthy adolescents. Procedure...
Children’s Healthcare of Atlanta, Georgia and Emory UniversityTransitioning from pediatric to adult care is a challenging process for adolescents withsickle cell disease (SCD). There critical need well-designed practicallyadaptable SCD transition programs that are compatible within the social culturalcontext individual. The purpose this article outline design atheoretically informed intervention facilitate successful andyoung adults (AYAs) diagnosed with SCD. authors propose describe useof...