Deqi Chen

ORCID: 0000-0001-9377-0116
Publications
Citations
Views
---
Saved
---
About
Contact & Profiles
Research Areas
  • Synthetic Organic Chemistry Methods
  • Synthesis of Organic Compounds
  • Chemical synthesis and alkaloids
  • Inorganic and Organometallic Chemistry
  • Asymmetric Synthesis and Catalysis
  • Lipid metabolism and disorders
  • Chemical Synthesis and Reactions
  • Autophagy in Disease and Therapy
  • Total Knee Arthroplasty Outcomes
  • Peroxisome Proliferator-Activated Receptors
  • Pelvic and Acetabular Injuries
  • Chronic Kidney Disease and Diabetes
  • Biopolymer Synthesis and Applications
  • Renal Diseases and Glomerulopathies
  • Cancer-related molecular mechanisms research
  • Morinda citrifolia extract uses
  • Orthopaedic implants and arthroplasty
  • Pregnancy-related medical research
  • Metabolism, Diabetes, and Cancer
  • RNA Interference and Gene Delivery
  • Phagocytosis and Immune Regulation
  • Cholesterol and Lipid Metabolism
  • Virus-based gene therapy research
  • Glioma Diagnosis and Treatment
  • Bone and Joint Diseases

Chinese Academy of Medical Sciences & Peking Union Medical College
2021

Guangdong Pharmaceutical University
2020

Guangzhou Medical University
2012

Guangzhou First People's Hospital
2012

University of Iowa
1998-2001

Diabetic nephropathy (DN) is the primary cause of end-stage renal disease worldwide. Although etiology for DN complex and still needs to be fully understood, lipid metabolism disorder found play a role in it. Previously, we Yishen Huashi (YSHS) granule could inhibit diabetic damage reduce level microalbuminuria (mALB) animals. To explore its mechanism under settings, this study was designed.DN rats were induced by streptozotocin (STZ), HepG2 CaCO2 cells applied vitro study. Hematoxylin-Eosin...

10.1016/j.heliyon.2023.e14171 article EN cc-by-nc-nd Heliyon 2023-03-01

Background: Diabetic nephropathy (DN) is one of the most common complications diabetes and primary cause end-stage renal disease. At present, renin-angiotensin-aldosterone system (RAAS) blockers have been applied as first-class drugs to restrain development DN; however, its long-term effect limited. Recent evidence has shown definite effects Chinese medicine on DN. Yishen Huashi (YSHS) granule a traditional Medicine prescription that used in clinic treat DN, but mechanism not understood....

10.3389/fphar.2022.872940 article EN cc-by Frontiers in Pharmacology 2022-07-22

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTDihydropyrones as Dienophiles in the Diels−Alder Reaction: Application to Synthesis of 1-OxadecalonesDeqi Chen, Junquan Wang, and Nancy I. TotahView Author Information Department Chemistry, University Iowa, Iowa City, 52242 Cite this: J. Org. Chem. 1999, 64, 6, 1776–1777Publication Date (Web):February 27, 1999Publication History Received29 December 1998Published online27 February 1999Published inissue 1 March...

10.1021/jo982488g article EN The Journal of Organic Chemistry 1999-02-27

Abstract Anemarrhena asphodeloides Bunge is a traditional Chinese medicine. The timosaponin BII one of the most abundant and widely studied active ingredients in . Related studies have shown that has potential value for development further utilization. protective effect on islet β cells under type 2 diabetes was investigated glycolipid toxic INS‐1 cell model possible biomarkers were explored by lipidomics analysis. Timosaponin isolated from polyamide resin Sephadex LH‐20. Then, toxicity...

10.1002/cbdv.201900684 article EN Chemistry & Biodiversity 2020-02-17

In this study, we investigated the lipid metabolism regulatory activity of a novel metformin derivative (MD568) and its potential mechanism action in obese rats with type 2 diabetes mellitus (T

10.1111/1440-1681.13302 article EN Clinical and Experimental Pharmacology and Physiology 2020-03-10

Hippocampal-avoidance prophylactic cranial irradiation (HA-PCI) offers potential neurocognitive benefits but raises technical challenges to treatment planning. This study aims improve the conventional planning method using volumetric modulated arc therapy (VMAT) technique and investigate a better patient's head positioning achieve high quality of HA-PCI plans.The improved set wide expansion hippocampus as special region for dose decline. The whole brain target was divided into two parts...

10.1002/acm2.13217 article EN cc-by Journal of Applied Clinical Medical Physics 2021-04-07

Hypertensive nephropathy (HN) is a kind of renal disease caused by essential hypertension that eventually worsens into end-stage (ESRD). HN could damage the tubules, induce kidney and failure, increase risk stroke, heart or death, but there are few ideal drugs for treatment.In this study, we explored therapeutic effect bajijiasu (a compound from Morinda officinalis how common traditional Chinese medicine tonifying kidney) on rat model. Biochemical analysis, HE staining, PAS staining were...

10.2174/1874467215666221005141210 article EN Current Molecular Pharmacology 2022-10-06

A reversal of the stereochemistry base mediated isomerisation some isonitrile epoxides to hydroxy-vinyl isonitriles on changing from lithium diisopropylamide bis(trimethylsilyl)amide is reported and applied a synthesis racemic desepoxyaerocyanidin.

10.1039/a706830a article EN Chemical Communications 1997-01-01

Objective To investigate the effect of functional rehabilitation training path to periprosthetic bone mass change after total hip arthroplasty.Methods A 46 patients with femoral neck fractures and elderly osteoarthritis from December 2009 2010 who received arthroplasty were selected randomly divided into experimental group control group.The early physical therapy besides routine care,while in care orthopedic surgery.All followed up an average 14 months,Harris score density examined lweek,3...

10.3760/cma.j.issn.1673-4351.2012.03.049 article EN International journal of nursing 2012-03-08

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at glance that was extracted from about 100 leading journals. To access of an article which published elsewhere, please select “Full Text” option. The original trackable via the “References”

10.1002/chin.200116143 article EN ChemInform 2001-04-17

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at glance that was extracted from about 100 leading journals. To access of an article which published elsewhere, please select “Full Text” option. The original trackable via the “References”

10.1002/chin.199929140 article EN ChemInform 1999-07-20
Coming Soon ...