A5010998163- Respiratory Support and Mechanisms
- Cardiac electrophysiology and arrhythmias
- Healthcare Technology and Patient Monitoring
- Hemodynamic Monitoring and Therapy
- Cardiac, Anesthesia and Surgical Outcomes
- Ion channel regulation and function
- Diet and metabolism studies
- Cardiac Arrest and Resuscitation
- Renal function and acid-base balance
- Neonatal Respiratory Health Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Veterinary Pharmacology and Anesthesia
- Anesthesia and Neurotoxicity Research
- Hemophilia Treatment and Research
- ECG Monitoring and Analysis
- Cardiac Valve Diseases and Treatments
- Neuroscience of respiration and sleep
- Blood Coagulation and Thrombosis Mechanisms
- Thermal Regulation in Medicine
- Intensive Care Unit Cognitive Disorders
- Pleural and Pulmonary Diseases
- Non-Invasive Vital Sign Monitoring
- Pneumothorax, Barotrauma, Emphysema
- Airway Management and Intubation Techniques
- Research on Leishmaniasis Studies
University of Liverpool
2021-2025
Amrita Institute of Medical Sciences and Research Centre
2012-2020
Medizinische Hochschule Hannover
2019
Amrita Vishwa Vidyapeetham
2012
Erasmus University Rotterdam
1982-2005
Fortis Escorts Heart Institute
1995
Rotterdam University of Applied Sciences
1989-1990
Netherlands Heart Institute
1989
Royal London Hospital
1986
The Honourable Society of Lincoln's Inn
1986
Pulmonary capillary wedge pressure (PCWP) is monitored during anesthesia in an attempt to detect changes myocardial function patients at risk of preoperative cardiac complications. Because the sensitivity with which PCWP monitoring indicates ischemia uncertain, we PCWP, 12-lead electrocardiogram, and left ventricular wall motion abnormalities as defined by transesophageal echocardiography (TEE) 98 anesthetized before coronary artery bypass grafting. Measurements were made five times each...
Abstract Aim Long QT syndrome (LQTS) and catecholaminergic polymorphism ventricular tachycardia (CPVT) are inherited cardiac disorders often caused by mutations in ion channels. These arrhythmia syndromes have recently been associated with calmodulin (CaM) variants. Here, we investigate the impact of arrhythmogenic variants D131E Q135P on CaM's structure–function relationship. Our study focuses L‐type calcium channel Ca v 1.2, a crucial component action potential excitation–contraction...
A eomparative study was undertaken to evaluate the effectiveness of epidural sufentanil in providing intraand postoperative analgesia during thoracic surgery. Sufentanil chosen on basis its high lipid solubility and potent opiate receptor binding. Epidural compared with intravenous as major intraoperative analgetic agent an anesthesia regimen midazolam nitrous oxide. significantly decreased need for supplementary analgesia. In group immediate found be better, a longer duration action, group....
Abstract Calmodulin (CaM) is a highly conserved mediator of calcium (Ca 2+ )‐dependent signalling and modulates various cardiac ion channels. Genotyping has revealed several CaM mutations associated with long QT syndrome (LQTS). LQTS patients display prolonged ventricular recovery times (QT interval), increasing their risk incurring life‐threatening arrhythmic events. Loss‐of‐function to Kv7.1 (which drives the slow delayed rectifier potassium current, IKs, key repolarising current) are...
To study the incidence of spontaneous echo contrast in left atrium Indian patients with rheumatic mitral stenosis normal sinus rhythm and to define its relations.Transthoracic multiplane transoesophageal echocardiographic studies were performed 89 consecutive who rhythm.Spontaneous was seen 57.3% on echocardiography only 5.6% transthoracic echocardiography. The mean valve area 1.07 (SD 0.33) cm2 1.32 (0.45) (P = 0.004), atrial size 4.27 (0.67) cm 3.91 (0.5) 0.029), diastolic pressure...
Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an inherited condition that can cause fatal cardiac arrhythmia. Human mutations in the Ca2+ sensor calmodulin (CaM) have been associated with CPVT susceptibility, suggesting CaM dysfunction a key driver of disease. However, detailed molecular mechanism remains unclear. Focusing on interaction ryanodine receptor (RyR2), we determined effect CPVT-associated variants N53I and A102V structural characteristics fluxes live cells. We...
Leishmaniasis is a neglected disease that caused by different species of the protozoan parasite Leishmania, and it currently affects 12 million people worldwide. The antileishmanial therapeutic arsenal remains very limited in number efficacy, there no vaccine for this parasitic disease. One pathway has been genetically validated as an drug target biosynthesis uridine diphosphate-glucose (UDP-Glc), its direct derivative UDP-galactose (UDP-Gal). De novo these two nucleotide sugars controlled...
Long QT syndrome (LQTS) is a human inherited heart condition that can cause life-threatening arrhythmia including sudden cardiac death. Mutations in the ubiquitous Ca2+-sensing protein calmodulin (CaM) are associated with LQTS, but molecular mechanism by which these mutations lead to irregular heartbeats not fully understood. Here, we use multidisciplinary approach biophysics, structural biology, confocal imaging, and patch-clamp electrophysiology determine effect of disease-associated CaM...
The concept of substrate inhibition to prevent its phosphorylation has potential in drug discovery and is envisioned treat the autoimmune disorder multiple sclerosis (MS). Glia maturation factor-β (GMF-β) Ser83 by protein kinase A (PKA) pivotal activation GMF-β-p38MAPK-NFκB biochemical pathway towards proinflammatory response induction experimental encephalomyelitis (EAE). Using structure-based design, we identified small molecule inhibitor 1-H-indazole-4yl methanol (GMFBI.1) that...
In response to the increasing abilities provide continuous and detailed information on cardiopulmonary status during after open heart surgery, we measured hemodynamic pulmonary functions including cardiac index, end-tidal CO2, minute volume, dead space, ventilation/perfusion ratio, O2 consumption, other derived variables with a mass spectrometer. This was found useful, for example, in evaluating need artificial ventilation postoperative patients.