A5057629359- Circadian rhythm and melatonin
- Adipose Tissue and Metabolism
- Circular RNAs in diseases
- Genetics, Aging, and Longevity in Model Organisms
- Dietary Effects on Health
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Cardiovascular Disease and Adiposity
- Stress Responses and Cortisol
Third Xiangya Hospital
2021-2024
Central South University
2021-2024
Abstract The disruption of circadian rhythms caused by long-term shift work can cause metabolic diseases such as obesity. Early growth response 3 (EGR3) is a member early (EGR) family, which involved in several cellular responses, had been reported rhythm gene suprachiasmatic nucleus. In this research, EGR3 was found to be widely expressed the different tissue human and mice, downregulated adipose obese subjects high-fat diet mice. Moreover, negatively regulated cortisol. addition, key...
Type 2 diabetes mellitus (T2DM) increases the incidence of diabetic nephropathy (DN) and eventually progresses to end-stage renal disease. Circular RNAs (circRNAs) are a class non-coding that promising as diagnostic biomarkers therapeutic targets for human diseases. The aim this study was analyze differential expression circRNAs (DECs) in peripheral blood from patients with early type (ET2DN), T2DM controls, which will facilitate discover some new ET2DN. Twenty ET2DN patients, 20 normal...
Abstract The period circadian regulator 3 (PER3) has been reported to play a negative role in human immortalized bone marrow-derived Scp-1 cells (iBMSCs) and patient adipose-derived stromal (PASCs) or negative/positive mice adipogenesis. However, PER3 (hPER3) was identified as positive of adipose tissue-derived (hADSCs) adipogenesis this study. Silencing overexpression hPER3 hADSCs inhibited promoted vitro. In vivo, the increased high-fat diet-induced inguinal white tissue (iWAT) epididymal...
Brown adipose tissue (BAT) can rapidly generate heat and improve energy metabolism. Circular RNAs (circRNAs) are cellular endogenous non-coding RNAs, which regulate the development progress of different diseases. However, role circRNAs in human BAT is not fully understood. Here, we analyzed differentially expressed (DECs) BAT, as well white (WAT), identified new biomarkers BAT.Three three subcutaneous WAT samples were selected, circRNA microarray was performed. Additionally, quantitative...