A5038879101- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Adipose Tissue and Metabolism
- Simulation Techniques and Applications
- RNA and protein synthesis mechanisms
- Circadian rhythm and melatonin
- Industrial Technology and Control Systems
- Diabetes Treatment and Management
- Cardiovascular Disease and Adiposity
- Stress Responses and Cortisol
- Apelin-related biomedical research
- Collaboration in agile enterprises
- Renal Diseases and Glomerulopathies
- RNA modifications and cancer
Third Xiangya Hospital
2022-2025
Central South University
2022-2025
Beihang University
2023
Abstract The disruption of circadian rhythms caused by long-term shift work can cause metabolic diseases such as obesity. Early growth response 3 (EGR3) is a member early (EGR) family, which involved in several cellular responses, had been reported rhythm gene suprachiasmatic nucleus. In this research, EGR3 was found to be widely expressed the different tissue human and mice, downregulated adipose obese subjects high-fat diet mice. Moreover, negatively regulated cortisol. addition, key...
Abstract Dysfunctional adipogenesis is a major contributor of obesity. N-acetyltransferase 10 (NAT10) plays crucial role in regulating N4-acetylcysteine (ac4C) modification tRNA, 18SrRNA, and mRNA. As the sole “writer” ac4C process, NAT10 enhances mRNA stability translation efficiency. There are few reports on relationship between adipogenesis, as well Our study revealed significant upregulation adipose tissues obese individuals high-fat diet-fed mice. Furthermore, our findings that...
Metabolic dysfunction associated steatotic liver disease (MASLD), closely linked to excessive lipogenesis, induces chronic disease. MASLD often cause other metabolic diseases, such as cardiovascular disease, diabetes and obesity. However, the mechanism of N-acetyltransferase 10 (NAT10)-mediated N4-acetylcytidine (ac4C) mRNA modification in lipogenesis has not been fully elucidated. This study investigated role NAT10 targeting ac4C modification. The expression mouse was assessed after a...
Type 2 diabetes mellitus (T2DM) increases the incidence of diabetic nephropathy (DN) and eventually progresses to end-stage renal disease. Circular RNAs (circRNAs) are a class non-coding that promising as diagnostic biomarkers therapeutic targets for human diseases. The aim this study was analyze differential expression circRNAs (DECs) in peripheral blood from patients with early type (ET2DN), T2DM controls, which will facilitate discover some new ET2DN. Twenty ET2DN patients, 20 normal...
Brown adipose tissue (BAT) can rapidly generate heat and improve energy metabolism. Circular RNAs (circRNAs) are cellular endogenous non-coding RNAs, which regulate the development progress of different diseases. However, role circRNAs in human BAT is not fully understood. Here, we analyzed differentially expressed (DECs) BAT, as well white (WAT), identified new biomarkers BAT.Three three subcutaneous WAT samples were selected, circRNA microarray was performed. Additionally, quantitative...
For the emerging autonomous swarm technology, from perspective of systems science and engineering, there must be some novel elements methods to aggregate multiple into a group, which distinguish with general components specific functions, we expect provide presentation their existence in development processes. The inspiration our methodology origins integration ontology, multi-paradigm modeling, multi-agent system, cyber-physical etc. Therefore, choose model-driven technology as framework...
Purpose: Adipogenesis is one of the major pathways for generating obesity or overweight that can cause a range metabolic disorders. Circular RNAs (circRNAs), specific type RNAs, have significant influence on This study aims to find differentially expressed circRNAs (DECs) during human subcutaneous adipose tissue (SATs) adipogenesis. Patients and Methods: The tissue-derived stromal cells (hADSCs) were isolated from SATs (n = 3), then induced into adipocytes. Total extracted hADSCs adipocytes,...
Obesity related glomerulopathy (ORG) is induced by obesity, but the pathogenesis remains unclear. This study aims to investigate expression of early growth response protein 3 (EGR3) in renal cortex tissues ORG patients and high-fat diet-induced obese mice, further explore molecular mechanism EGR3 inhibiting palmitic acid (PA) human podocyte inflammatory damage.