A5034445592- Immune Response and Inflammation
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- S100 Proteins and Annexins
- Inflammasome and immune disorders
- Respiratory Support and Mechanisms
- Immune Cell Function and Interaction
- Neuroinflammation and Neurodegeneration Mechanisms
- Immune cells in cancer
- Phagocytosis and Immune Regulation
- Immune responses and vaccinations
- Neonatal Respiratory Health Research
- Cytokine Signaling Pathways and Interactions
- Fatty Acid Research and Health
- Inflammatory mediators and NSAID effects
- Adipokines, Inflammation, and Metabolic Diseases
- Cell Adhesion Molecules Research
- Acute Kidney Injury Research
- Nitric Oxide and Endothelin Effects
- Lipoproteins and Cardiovascular Health
- Sepsis Diagnosis and Treatment
Université de Montréal
2017-2023
Hôpital Maisonneuve-Rosemont
2017-2023
Abstract The uptake of apoptotic polymorphonuclear cells (PMN) by macrophages is critical for timely resolution inflammation. High-burden associated with loss phagocytosis in phase macrophages. Here, using a transcriptomic analysis macrophage subsets, we show that non-phagocytic express distinct IFN-β-related gene signature mice. We also report elevated levels IFN-β peritoneal and broncho-alveolar exudates mice during the peritonitis pneumonia, respectively. Elimination endogenous impairs,...
Significance Timely resolution of bacterial infections critically depends on phagocytosis invading pathogens by polymorphonuclear neutrophil granulocytes, followed apoptosis and removal macrophages. Neutrophils integrate cues from the inflammatory microenvironment. Here we show a Toll-like receptor 9-mediated mechanism, involving regulation phagocytosis-induced apoptosis, which DNA, pathogen-associated molecular pattern, danger signal mitochondrial DNA may impair host defense to bacteria...
Aberrant immune responses, including hyperresponsiveness to Toll-like receptor (TLR) ligands, underlie acute respiratory distress syndrome (ARDS). Type I interferons confer antiviral activities and could also regulate the inflammatory response, whereas little is known about their actions resolve aberrant inflammation. Here we report that interferon-β (IFN-β) exerts partially overlapping, but cooperative with aspirin-triggered 15-epi-lipoxin A 4 (15-epi-LXA ) 17-epi-resolvin D1 counter...
Abstract Accumulating evidence indicates development of local extracellular acidosis in inflamed tissues response to infection and tissue injury. Activation infiltrating neutrophils contributes a transient decrease pH, which, turn, triggers innate immunity. In this study, we investigated the impact on neutrophil apoptosis, critical determinant outcome inflammatory analyzed underlying signaling pathways. Culture human isolated mildly acidotic conditions (pH 6.5–7.0) resulted activation NF-κB;...
Abstract Killing of invading bacteria is essential for efficient control infection and return to homeostasis. Phagocytosis E. coli by neutrophils induces neutrophil apoptosis subsequent efferocytosis, critical points the outcome inflammation. Recently, we found that DNA impairs phagocytosis human neutrophils, delays prolongs coli-evoked lung injury in mice. Here, investigated whether flavonoid galangin, which was shown exert anti-inflammatory actions several inflammation models, could also...
Abstract Neutrophil dysfunction, resulting in delayed apoptosis and inefficient bacterial clearance, is a characteristic feature of severe pathologies, including sepsis cystic fibrosis. Human neutrophils detect respond to DNA (CpG DNA) through TLR9. We investigated the impact CpG on phagocytosis, phagocytosis-induced neutrophil clearance E coli. Culture human with (0.1–3.2 μg/ml) resulted decreased phagocytosis opsonized E. coli or yeast. upregulated C3R (CD11b) expression, downregulated...