A5030750309- Malaria Research and Control
- Extracellular vesicles in disease
- Genomics and Chromatin Dynamics
- Evolution and Genetic Dynamics
- CRISPR and Genetic Engineering
- Invertebrate Immune Response Mechanisms
- Parasites and Host Interactions
- Trypanosoma species research and implications
- Parasite Biology and Host Interactions
- Research on Leishmaniasis Studies
- Mosquito-borne diseases and control
- HIV Research and Treatment
- vaccines and immunoinformatics approaches
- Antimicrobial Peptides and Activities
- Viral Infections and Vectors
- interferon and immune responses
Weizmann Institute of Science
2021-2025
Abstract Pathogens are thought to use host molecular cues control when initiate life-cycle transitions, but these signals mostly unknown, particularly for the parasitic disease malaria caused by Plasmodium falciparum . The chemokine CXCL10 is present at high levels in fatal cases of cerebral patients, reduced patients who survive and do not have complications. Here we show a Pf ‘decision-sensing-system’ controlled concentration. High expression prompts P. survival strategy via growth...
Hundreds of thousands die annually from malaria caused by Plasmodium falciparum (Pf), with the emergence drug-resistant parasites hindering eradication efforts. Antimicrobial peptides (AMPs) are known for their ability to disrupt pathogen membranes without targeting specific receptors, thereby reducing chance drug resistance. However, effectiveness and biophysical mechanisms which they target intracellular parasite remain unexplored. Here, using native synthetic AMPs, we discovered a...
Cells across biological kingdoms release extracellular vesicles (EVs) as a means of communication with other cells, be their friends or foes. This is indeed true for the intracellular malaria parasite Plasmodium falciparum (Pf), which utilizes EVs to transport bioactive molecules various human host systems. Yet, study this mode in research currently constrained due limitations high-resolution tools and absence commercial antibodies. Here, we demonstrate power an advanced spectral flow...
Plasmodium falciparum (Pf) is the leading protozoan causing malaria, most devastating parasitic disease. To ensure transmission, a small subset of Pf parasites differentiate into sexual forms (gametocytes). Since abundance these essential extremely low within human host, little currently known about molecular regulation their differentiation, highlighting need to develop tools investigate gene expression during this fundamental mechanism.We developed high-throughput quantitative...
Exploring the intricacies of host-pathogen communication is vital in order to understand why some microbes persist within a host, while others are effectively cleared. As such, an urgent area research underpinning human health and disease, especially given emerging concerns antibiotic resistance. Understanding pathways requires intricate knowledge fields both microbiology immunology. Living world specialists, where scientists sometimes invest their whole career studying one organism,...