A5018441511- Schizophrenia research and treatment
- Treatment of Major Depression
- Bipolar Disorder and Treatment
- Ophthalmology and Visual Impairment Studies
- Ophthalmology and Visual Health Research
- Hearing, Cochlea, Tinnitus, Genetics
- Retinal and Optic Conditions
- Electroconvulsive Therapy Studies
- Hearing Loss and Rehabilitation
- Diet and metabolism studies
- Global Maternal and Child Health
- Travel-related health issues
- Pharmacological Effects and Toxicity Studies
- Adipose Tissue and Metabolism
- Occupational Therapy Practice and Research
- Corneal surgery and disorders
- Diverse Educational Innovations Studies
- Hearing Impairment and Communication
- Noise Effects and Management
- Lipid metabolism and biosynthesis
- Tryptophan and brain disorders
- Health Literacy and Information Accessibility
- Telemedicine and Telehealth Implementation
- Educational Assessment and Improvement
- Vestibular and auditory disorders
Queen's University Belfast
2021-2025
Alkermes (United States)
2018-2023
University of KwaZulu-Natal
2019-2023
Alkermes (Ireland)
2018-2021
Zucker Hillside Hospital
2020
Northwell Health
2020
Donald & Barbara Zucker School of Medicine at Hofstra/Northwell
2020
West Cumberland Hospital
2015
Tufts University
2010-2013
Jean Mayer Human Nutrition Research Center on Aging
2011-2013
The cytoplasmic lipid droplet (CLD) protein perilipin-2 (Plin2) is expressed in multiple nonadipose tissues, where it thought to play a role regulating their storage properties. However, the extent which Plin2 functions nutrient utilization and metabolism, or how influences consequences of over-feeding, remains unclear. In this study, we demonstrate that absence prevents high-fat diet(HFD)-induced obesity male female mice. This response associated with increased formation subcutaneous beige...
A combination of olanzapine and the opioid receptor antagonist samidorphan is under development for treatment schizophrenia bipolar I disorder. The single-tablet intended to provide efficacy while mitigating olanzapine-associated weight gain. In this phase 3 double-blind trial, authors evaluated profile combined olanzapine/samidorphan compared with in patients schizophrenia.Adults (ages 18‒55 years) were randomly assigned receive either or 24 weeks. Primary endpoints percent change from...
Mitogen-activated protein kinases (MAPKs), consisting of three major enzymes-extracellular signal-regulated kinase (ERK), p38, and c-jun N-terminal (JNK)-couple cell-surface receptors to critical regulatory targets gene transcription. We hypothesized that MAPKs are differentially expressed have distinct functions after retinal ischemia.Rats were subjected ischemia by elevation intraocular pressure. Changes in MAPK expression examined Western blot whole homogenates immunohistochemistry...
Background A pilot eyecare programme aimed to address the urgent eye health needs of older Zanzibari craftswomen. We investigated impact correcting presbyopia on their subjective well-being (SWB) 6 months post-correction and assessed cost-effectiveness a women-targeted correction programme. Methods This study involved craftswomen aged 40 with presenting corrected distance visual acuity better than 6/12 in both eyes were presbyopic. Using before–after method, we SWB 10-point scale before...
Injectable extended-release naltrexone (XR-NTX), approved to prevent relapse opioid dependence, requires initial abstinence. This multisite outpatient clinical trial examined the efficacy and safety of low-dose oral (NTX), combined with a brief buprenorphine (BUP) taper standing ancillary medications, for detoxification induction onto XR-NTX.Patients (N = 378) were randomized, stratified by primary short-acting opioid-of-use, one three regimens: NTX + BUP; placebo BUP (PBO-B); (PBO-N) PBO-B....
A combination of olanzapine and samidorphan (OLZ/SAM) is in development for the treatment patients with schizophrenia or bipolar I disorder intended to provide efficacy while mitigating olanzapine-associated weight gain. This 52-week open-label extension (NCT02873208; ENLIGHTEN-2-EXT) assessed long-term safety tolerability OLZ/SAM schizophrenia.Patients completing 24-week randomized, double-blind, phase 3 ENLIGHTEN-2 study (NCT02694328) comparing change from baseline week 24 versus were...
Cells of the inner ear face constant metabolic and structural stress. Exposure to intense sound or certain drugs destroys cochlea hair cells, which in mammals do not regenerate. Thus, an endogenous stress response system may exist within protect it from everyday stressors. We recently described existence corticotropin-releasing factor (CRF) mouse cochlea. The CRF receptor type 1 (CRFR1) is considered primary canonical target signaling, systemically plays essential role coordinating body-wide...
Weight gain and adverse cardiometabolic effects often limit the clinical utility of olanzapine. In ENLIGHTEN-2, combining olanzapine with opioid receptor antagonist samidorphan (OLZ/SAM) mitigated olanzapine-associated weight gain. These analyses tested hypothesis that OLZ/SAM would be associated reduced compared olanzapine.This phase 3 double-blind study randomized adults schizophrenia to or for 24 weeks. Post hoc assessed changes from baseline week in risk parameters, including body mass...
To assess needs and views regarding eye health empowerment from craftswomen's perspectives to develop a theory of change (ToC) for women-targeted eyecare programme.
Combination olanzapine and samidorphan (OLZ/SAM), in development for schizophrenia bipolar I disorder, is intended to provide the efficacy of while mitigating olanzapine-associated weight gain. OLZ/SAM safety, tolerability, from a 52-week open-label extension study patients with are reported.Patients previously completing 4-week, double-blind ENLIGHTEN-1 switched OLZ/SAM, olanzapine, or placebo OLZ/SAM. Assessments included adverse events (AEs), weight, vital signs, Positive Negative...
Olanzapine is an atypical antipsychotic indicated for the treatment of schizophrenia and, either as monotherapy or adjunct to lithium valproate, bipolar I disorder. Multiple daily doses olanzapine do not affect pharmacokinetics valproate; therefore, concomitant administration does require dosage adjustment valproate. ALKS 3831, a combination and opioid receptor antagonist samidorphan (OLZ/SAM), currently under development provide established efficacy while mitigating olanzapine-induced...
Ensuring access to and promoting use of effective contraception have been identified as important strategies for preventing unintended pregnancy (1). The importance ensuring resources prevent in the context public health emergencies was highlighted during 2016 Zika virus outbreak when infection a cause serious birth defects (2). Accordingly, CDC outlined state, local, territorial jurisdictions consider implementing ensure (3). To update previously published contraceptive estimates* among...
Background Uncorrected refractive error (URE) is a major cause of vision impairment in children worldwide. Cases are often detected through school-based screening program and then treated follow-up appointment. This requires parents or guardians (‘parents’) to adhere referrals for the eye exam care plan. We aim understand reasons parents’ referral non-adherence Cross River State, Nigeria, using qualitative methods. Methods Ten focus groups were held with who had not adhered examination....
Objective To understand if presbyopia correction could empower older craftswomen entrepreneurs living in Zanzibar. Design Mixed-method, before-after intervention study. Setting Unguja and Pemba islands, Participants 209 (weaving, tailoring sewing, pottery producing oil making soaps) 40 years with correctable presbyopia, no other ocular morbidities. Intervention Eye health assessment near vision spectacle for 6 months. Primary secondary outcomes Change economic, social, psychological...
Background Studies have shown that correcting presbyopia among women could increase short-term income and quality of life. However, it is unclear whether these outcomes translate to long-term empowerment. This partly due women’s empowerment being under-studied in the eye health field. Hence, we attempted understand Zanzibari craftswomen’s perception how near-vision spectacle correction empower them. Methods Semi-structured interviews were conducted with 24 craftswomen (7 21 April 2022),...
Aged Zanzibari women are in a disadvantaged position, having high demand for near-vision spectacles. Currently, there is no information on the eye health status of craftswomen, which makes planning women-targeted project to deliver services older craftswomen Zanzibar difficult. We assessed prevalence vision impairment, refractive error, presbyopia, effective spectacle coverage (distance and near) attitude towards wearing among craftswomen.This was cross-sectional study. Unaided presenting...
Deprivation is associated with an increased risk of invasive Neisseria meningitidis disease, but little known about the relationship between deprivation and asymptomatic carriage N. meningitidis. This analysis was conducted to examine meningococcal deprivation.As part a rapid prevalence study in West Cumbria investigate apparent cluster data were collected on lifestyle social factors, including area-level indicators socioeconomic status, identify factors carriage.In multivariable log...