A5013568526- Zebrafish Biomedical Research Applications
- Hearing, Cochlea, Tinnitus, Genetics
- Molecular Biology Techniques and Applications
- QR Code Applications and Technologies
- Research Data Management Practices
- HIV/AIDS Research and Interventions
- HIV Research and Treatment
- Advanced Data Storage Technologies
- Erythrocyte Function and Pathophysiology
- Immune Cell Function and Interaction
- Neurogenesis and neuroplasticity mechanisms
- Nerve injury and regeneration
- Retinal Development and Disorders
- Cellular transport and secretion
- Neuroscience of respiration and sleep
- Congenital heart defects research
- interferon and immune responses
- Cancer-related molecular mechanisms research
- HIV-related health complications and treatments
- Phagocytosis and Immune Regulation
University of Pennsylvania
2024
University of Wisconsin–Madison
2018-2021
To support cell survival, mitochondria must balance energy production with oxidative stress. Inner ear hair cells are particularly vulnerable to stress; thus require tight mitochondrial regulation. We identified a novel molecular regulator of the cells’ and survival: Pregnancy-associated plasma protein-aa (Pappaa). Hair in zebrafish pappaa mutants exhibit defects, including elevated calcium, transmembrane potential, reactive oxygen species (ROS) reduced antioxidant expression. In mutants,...
Down syndrome cell adhesion molecules (DSCAMs) are broadly expressed in nervous systems and play conserved roles programmed death, neuronal migration, axon guidance, neurite branching spacing, synaptic targeting. However, DSCAMs appear to have distinct functions different vertebrate animals, little is known about their outside the retina. We leveraged genetic tractability optical accessibility of larval zebrafish investigate expression function a DSCAM family member, dscamb. Using targeted...
Little is known about how specific individual viral lineages replicating systemically during acute Human Immunodeficiency Virus or Simian (HIV/SIV) infection persist into chronic infection. In this study, we use molecularly barcoded SIV (SIVmac239M) to track distinct for 12 weeks after intravenous (IV) intrarectal (IR) challenge in macaques. Two Mafa-A1*063+ cynomolgus macaques ( Macaca fascicularis , CM) were challenged IV, and two Mamu-A1*001+ rhesus mulatta RM) IR with 200,000 Infectious...
Abstract Optic nerve (ON) regeneration in mammalian systems is limited by an overshadowing dominance of inhibitory factors. This has severely hampered the identification pro- regenerative pathways. Here, we take advantage capacity larval zebrafish to identify pathways that promote ON regeneration. From a small molecule screen, identified modulators serotonin (5-HT) signaling inhibit We find several type-1 receptor genes are expressed RGC neurons during and inhibiting 5- HT1 receptors or...
Little is known about how individual virus lineages replicating during acute Human Immunodeficiency Virus or Simian (HIV/SIV) infection persist into chronic infection. In this study, we use molecularly barcoded SIV (SIVmac239M) to track distinct viral for 12 weeks after intravenous and intrarectal challenge in macaques. Two Mafa-A1*063+ cynomolgus macaques (Macaca fascicularis) were challenged intravenously (IV), two Mamu-A1*001+ rhesus mulatta) intrarectally (IR) with 200,000 Infectious...
Abstract To support cell survival, mitochondria must balance energy production with oxidative stress. Inner ear hair cells are particularly vulnerable to stress; thus require tight mitochondrial regulation. We identified a novel molecular regulator of the cells’ and survival: Pregnancy-associated plasma protein-aa (Pappaa). Hair in zebrafish pappaa mutants exhibit defects, including elevated calcium, transmembrane potential, reactive oxygen species (ROS) reduced antioxidant expression. In...