A5025848480- Immunotherapy and Immune Responses
- Histone Deacetylase Inhibitors Research
- CAR-T cell therapy research
- Skin and Cellular Biology Research
- Cancer Cells and Metastasis
- Immune cells in cancer
- HIV Research and Treatment
- Immune Cell Function and Interaction
- Galectins and Cancer Biology
- Advanced Data Storage Technologies
- T-cell and B-cell Immunology
- Molecular Biology Techniques and Applications
- Cancer Immunotherapy and Biomarkers
- QR Code Applications and Technologies
- HIV/AIDS Research and Interventions
- Research Data Management Practices
- Radiation Dose and Imaging
- Traumatic Brain Injury and Neurovascular Disturbances
- Cellular Mechanics and Interactions
- Protein Tyrosine Phosphatases
- Cancer-related molecular mechanisms research
- HIV-related health complications and treatments
- Cancer-related Molecular Pathways
- Hemodynamic Monitoring and Therapy
- Ferroptosis and cancer prognosis
University of Wisconsin–Madison
2017-2025
Wisconsin Institutes for Discovery
2023
Abstract Purpose: We investigated whether in human head and neck squamous cell carcinoma (HNSCC) high levels of expression stress keratin 17 (K17) are associated with poor survival resistance to immunotherapy. Experimental Design: the role K17 regulating both tumor microenvironment immune responsiveness HNSCC using a syngeneic mouse model, MOC2. MOC2 gives rise immunologically cold tumors that resistant immune-checkpoint blockade (ICB). engineered multiple, independent knockout (KO) lines...
Background: Approximately 15-20% of head and neck cancer squamous cell carcinoma (HNSCC) patients respond favorably to immune checkpoint blockade (ICB). Previous single-cell RNA-Seq (scRNA-Seq) studies identified features, including macrophage subset ratios T-cell subtypes, in HNSCC ICB response. However, the spatial features HNSCC-infiltrated cells response treatment need be better characterized. Methods: Here, we perform a systematic evaluation interactions between types within tumor...
Low response rates in immune check-point blockade (ICB)-treated head and neck squamous cell carcinoma (HNSCC) drive a critical need for robust, clinically validated predictive biomarkers. Our group previously showed that stress keratin 17 (CK17) suppresses macrophage-mediated CXCL9/CXCL10 chemokine signaling involved attracting activated CD8+ T cells into tumors, correlating with decreased rate to pembrolizumab-based therapy pilot cohort of ICB-treated HNSCC (n = 26). Here, we performed an...
Little is known about how specific individual viral lineages replicating systemically during acute Human Immunodeficiency Virus or Simian (HIV/SIV) infection persist into chronic infection. In this study, we use molecularly barcoded SIV (SIVmac239M) to track distinct for 12 weeks after intravenous (IV) intrarectal (IR) challenge in macaques. Two Mafa-A1*063+ cynomolgus macaques ( Macaca fascicularis , CM) were challenged IV, and two Mamu-A1*001+ rhesus mulatta RM) IR with 200,000 Infectious...
While antiretroviral therapy (ART) can suppress HIV replication, it is not a cure. It therefore essential to develop therapeutic strategies enhance the immune system better become activated and recognize virus-infected cells.
Little is known about how individual virus lineages replicating during acute Human Immunodeficiency Virus or Simian (HIV/SIV) infection persist into chronic infection. In this study, we use molecularly barcoded SIV (SIVmac239M) to track distinct viral for 12 weeks after intravenous and intrarectal challenge in macaques. Two Mafa-A1*063+ cynomolgus macaques (Macaca fascicularis) were challenged intravenously (IV), two Mamu-A1*001+ rhesus mulatta) intrarectally (IR) with 200,000 Infectious...
Supplementary Figure from Stress Keratin 17 Expression in Head and Neck Cancer Contributes to Immune Evasion Resistance Immune-Checkpoint Blockade
Supplementary Figure from Stress Keratin 17 Expression in Head and Neck Cancer Contributes to Immune Evasion Resistance Immune-Checkpoint Blockade
Supplementary Data from Stress Keratin 17 Expression in Head and Neck Cancer Contributes to Immune Evasion Resistance Immune-Checkpoint Blockade
Supplementary Figure from Stress Keratin 17 Expression in Head and Neck Cancer Contributes to Immune Evasion Resistance Immune-Checkpoint Blockade
Supplementary Figure from Stress Keratin 17 Expression in Head and Neck Cancer Contributes to Immune Evasion Resistance Immune-Checkpoint Blockade
Supplementary Figure from Stress Keratin 17 Expression in Head and Neck Cancer Contributes to Immune Evasion Resistance Immune-Checkpoint Blockade
Supplementary Figure from Stress Keratin 17 Expression in Head and Neck Cancer Contributes to Immune Evasion Resistance Immune-Checkpoint Blockade
Supplementary Figure from Stress Keratin 17 Expression in Head and Neck Cancer Contributes to Immune Evasion Resistance Immune-Checkpoint Blockade
Supplementary Figure from Stress Keratin 17 Expression in Head and Neck Cancer Contributes to Immune Evasion Resistance Immune-Checkpoint Blockade
Supplementary Figure from Stress Keratin 17 Expression in Head and Neck Cancer Contributes to Immune Evasion Resistance Immune-Checkpoint Blockade
Supplementary Figure from Stress Keratin 17 Expression in Head and Neck Cancer Contributes to Immune Evasion Resistance Immune-Checkpoint Blockade
Supplementary Figure from Stress Keratin 17 Expression in Head and Neck Cancer Contributes to Immune Evasion Resistance Immune-Checkpoint Blockade
Supplementary Data from Stress Keratin 17 Expression in Head and Neck Cancer Contributes to Immune Evasion Resistance Immune-Checkpoint Blockade
Supplementary Figure from Stress Keratin 17 Expression in Head and Neck Cancer Contributes to Immune Evasion Resistance Immune-Checkpoint Blockade
Supplementary Figure from Stress Keratin 17 Expression in Head and Neck Cancer Contributes to Immune Evasion Resistance Immune-Checkpoint Blockade
Supplementary Figure from Stress Keratin 17 Expression in Head and Neck Cancer Contributes to Immune Evasion Resistance Immune-Checkpoint Blockade
Supplementary Figure from Stress Keratin 17 Expression in Head and Neck Cancer Contributes to Immune Evasion Resistance Immune-Checkpoint Blockade
Supplementary Figure from Stress Keratin 17 Expression in Head and Neck Cancer Contributes to Immune Evasion Resistance Immune-Checkpoint Blockade