A5027324102- Cytomegalovirus and herpesvirus research
- Neuroinflammation and Neurodegeneration Mechanisms
- RNA regulation and disease
- Herpesvirus Infections and Treatments
- HIV Research and Treatment
- Antibiotic Resistance in Bacteria
- Infectious Encephalopathies and Encephalitis
- Immune Cell Function and Interaction
- Bacterial biofilms and quorum sensing
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Media Studies and Communication
- PARP inhibition in cancer therapy
- Plant Virus Research Studies
- T-cell and B-cell Immunology
- Cancer-related Molecular Pathways
- Sexual Differentiation and Disorders
- RNA Interference and Gene Delivery
- Cancer Genomics and Diagnostics
- Head and Neck Cancer Studies
- Nitric Oxide and Endothelin Effects
- Biosensors and Analytical Detection
- DNA Repair Mechanisms
- Radiopharmaceutical Chemistry and Applications
- Lung Cancer Treatments and Mutations
- Prostate Cancer Treatment and Research
Medical College of Wisconsin
2020-2024
Johns Hopkins Medicine
2024
Johns Hopkins University
2024
University at Albany, State University of New York
2023
HealthPartners
2021
Cancer Research Center
2021
Abstract Quorum sensing is a mechanism of bacterial communication that controls virulence gene expression. Pseudomonas aeruginosa regulates via two synthase/transcription factor receptor pairs: LasI/R and RhlI/R. LasR considered the master transcriptional regulator quorum sensing, as it upregulates rhlI/R . However, clinical isolates often have inactivating mutations in lasR , while maintaining Rhl-dependent signaling. We sought to understand how progresses with mutations, specifically...
Human cytomegalovirus (HCMV) is a betaherpesvirus that can cause severe birth defects including vision and hearing loss, microcephaly, seizures. Currently, no approved treatment options exist for in utero infections. Here, we aimed to determine the impact of HCMV infection on transcriptome developing neurons an organoid model system. Cell populations isolated from organoids based marker transcriptomes were defined. We uncovered downregulation key cortical, neurodevelopmental, functional gene...
Human cytomegalovirus (HCMV) is a highly prevalent viral pathogen that can cause serious neurological deficits in infants experiencing an
Nitric oxide is a versatile and critical effector molecule that can modulate many cellular functions. Although recognized as regulator of infections, the inhibitory mechanism nitric against human cytomegalovirus (HCMV) replication remains elusive. We demonstrate attenuates viral by interfering with HCMV-mediated modulation several processes. exposure reduced HCMV genome synthesis infectious progeny cell-type-dependent differences observed. Mitochondrial respiration was severely in both...
Human cytomegalovirus (HCMV) is the leading cause of virus-mediated congenital birth defects. Congenitally infected infants can have a variety symptoms manifesting within central nervous system.
Human cytomegalovirus (HCMV) is a major cause of illness in immunocompromised individuals. The HCMV lytic cycle contributes to the clinical manifestations infection. occurs over ∼96 h diverse cell types and consists viral DNA (vDNA) genome replication temporally distinct expression hundreds proteins. Given its complexity, understanding this elaborate system can be facilitated by introduction mechanistic computational modeling temporal relationships. Therefore, we developed multiplicity...
ABSTRACT Human cytomegalovirus (HCMV) is a beta herpesvirus that causes severe congenital birth defects including microcephaly, vision loss, and hearing loss. Entry of HCMV into human cells determined by the composition glycoproteins in viral particles influenced source virus. We have previously shown infection stem cell-derived cerebral organoids significant downregulation critical neurodevelopmental genes, but mechanism entry neural tissues not well known. Here, we evaluated efficiency...
Human cytomegalovirus (HCMV) is a highly prevalent viral pathogen that typically presents asymptomatically in healthy individuals despite lifelong latency. However, 10-15% of congenital cases, this beta-herpesvirus demonstrates direct effects on the central nervous system, including microcephaly, cognitive/learning delays, and hearing deficits. HCMV has been widely shown to infect neural progenitor cells, but permissiveness fully differentiated neurons controversial chronically understudied,...
ABSTRACT Human cytomegalovirus (HCMV) is a prevalent betaherpesvirus, and infection can lead to range of symptomatology from mononucleosis sepsis in immunocompromised individuals. HCMV also the leading viral cause congenital birth defects. Lytic replication supported by many cell types with different kinetics efficiencies plethora pathologies. The goal these studies was elucidate for viruses produced on upon epithelial cells combining experimental approaches data-driven computational...
LBA5014 Background: Bipolar androgen therapy (BAT) for metastatic castration-resistant prostate cancer (mCRPC) is administered by alternating between supraphysiologic and near-castrate serum testosterone levels through intramuscular administration of cypionate 400mg given every 28 days together with ongoing suppression. BAT effective in a subset patients, but evidence predictive treatment selection lacking. The goal the study to determine whether blood-based markers can be identified...
Abstract Human cytomegalovirus (HCMV) is a beta herpesvirus that, upon congenital infection, can cause severe birth defects including vision and hearing loss, microcephaly, seizures. Currently, no approved treatment options exist for in utero infections. We previously demonstrated that HCMV infection decreases calcium signaling responses alters neuronal differentiation induced pluripotent stem cell (iPSC) derived neural progenitor cells (NPCs). Here we aimed to determine the impact of on...
Clinical manifestations of human cytomegalovirus (HCMV) infection, a major cause morbidity and mortality in the immunocompromised, are associated with lytic replication cycle. Lytic occurs over 96 hrs is marked by viral DNA (vDNA) synthesis expression proteins, latter which can be generalized into distinct temporal classifications. Given complexity cycle, mathematical modeling used to probe this elaborate system. Recently, has been study early cycle transition between latent cycles. To date,...
ABSTRACT Human cytomegalovirus (HCMV) is a beta herpesvirus that causes severe congenital birth defects including microcephaly, vision loss, and hearing loss. Infection of cerebral organoids with HCMV significant downregulation genes involved in critical neurodevelopmental pathways. The precise features the infection causing this dysregulation remain unknown. Entry into human cells determined by composition glycoproteins viral particles, which influenced source virus. This includes trimer...
Abstract Quorum sensing is a mechanism of bacterial communication that controls virulence gene expression. Pseudomonas aeruginosa regulates via two synthase/transcription factor receptor pairs: LasI/R and RhlI/R. LasR considered the master transcriptional regulator quorum sensing, as it upregulates rhlI/R . However, clinical isolates often have frequent inactivating mutations in lasR , while maintaining Rhl-dependent signaling. We sought to understand how progresses with mutations,...
Human cytomegalovirus (HCMV) is a beta herpesvirus that, upon congenital infection, can cause severe birth defects including vision and hearing loss, microcephaly, seizures. Currently, no approved treatment options exist for in utero infections. We previously demonstrated that HCMV infection decreases calcium signaling responses alters neuronal differentiation induced pluripotent stem cell (iPSC) derived neural progenitor cells (NPCs). Here we aimed to determine the impact of on...