A5089330319- Attention Deficit Hyperactivity Disorder
- EEG and Brain-Computer Interfaces
- Neural and Behavioral Psychology Studies
- Functional Brain Connectivity Studies
- Computational Drug Discovery Methods
- Neural dynamics and brain function
- Pharmacogenetics and Drug Metabolism
- Mental Health Research Topics
- Obsessive-Compulsive Spectrum Disorders
- Schizophrenia research and treatment
- Transcranial Magnetic Stimulation Studies
- Treatment of Major Depression
- Dementia and Cognitive Impairment Research
- Mental Health and Psychiatry
- Bipolar Disorder and Treatment
- Neurological Disorders and Treatments
- Psychology of Moral and Emotional Judgment
- Genetics and Neurodevelopmental Disorders
- Pharmaceutical studies and practices
- Autism Spectrum Disorder Research
- Body Image and Dysmorphia Studies
- Syphilis Diagnosis and Treatment
- Saffron Plant Research Studies
- Diet and metabolism studies
- Tryptophan and brain disorders
Semmelweis University
2012-2024
Országos Pszichiátriai és Neurológiai Intézet
2018
Most drugs exert their effects via multitarget interactions, as hypothesized by polypharmacology. While these interactions are responsible for the clinical effect profiles of drugs, current methods have failed to uncover complex relationships between them. Here, we introduce an approach which is able relate drug–protein interaction with profiles. Structural data and registered all small-molecule were collected, a series nontarget protein binding sites each drug calculated. Statistical...
Abstract Focusing attention on relevant information while ignoring distracting stimuli is essential to the efficacy of working memory. Alpha- and theta-band oscillations have been linked inhibition anticipated attentionally avoidable distractors. However, neurophysiological background rejection task-irrelevant appearing in focus not fully understood. We aimed examine whether theta alpha-band serve as an indicator successful distractor rejection. Twenty-four students were enrolled study....
Abstract Background Children with attention-deficit/hyperactivity disorder (ADHD) often demonstrate sensory processing difficulties in the form of altered modulation, which may contribute to their symptomatology. Our objective was investigate neurophysiological correlates deficits and electrophysiological characteristics early information adult ADHD, measured by P1 event-related potential (ERP). Methods We obtained ERPs during a Go/NoGo task from 26 patients ADHD 25 matched controls using...
Objectives: To delineate task-free gamma activity in adult ADHD and healthy control subjects based on high-density EEG recordings. Relationship of with symptom severity was also examined, since is considered to be an index network functions the brain that underlie higher-order cognitive processes.Methods: Spontaneous recorded (N = 42; 25 methylphenidate-naïve 17 methylphenidate treatment) controls 59) eyes open. absolute power investigated gamma1 (30.25-39 Hz) gamma2 (39.25-48 frequency...
The authors' aim was to investigate the modulation of event-related potentials (ERPs) by affective content stimuli in adult attention deficit hyperactivity disorder (ADHD) patients during error monitoring. By obtaining ERPs from 26 ADHD and 14 healthy controls an emotional go/no-go task, authors investigated two error-related ERP components, negativity (ERN) positivity (Pe). In patients, ERN amplitude decreased for negative after failed response inhibition ("no-go response") Pe neutral...
We recently introduced Drug Profile Matching (DPM), a novel affinity fingerprinting-based in silico drug repositioning approach. DPM is able to quantitatively predict the complete effect profiles of compounds via probability scores. In present work, order investigate predictive power DPM, three categories, namely, angiotensin-converting enzyme inhibitor, cyclooxygenase and dopamine agent, were selected predictions verified by literature analysis as well experimentally. A total 72% newly...
We recently introduced Drug Profile Matching (DPM), a novel virtual affinity fingerprinting bioactivity prediction method. DPM is based on the docking profiles of ca. 1200 FDA-approved small-molecule drugs against set nontarget proteins and creates predictions this pattern. The effectiveness approach was previously demonstrated for therapeutic effect drug molecules. In current work, we investigated applicability target fishing, i.e. biological targets compounds. Predictions were made 77...
Repetitive transcranial magnetic stimulation (rTMS) is an effective and well tolerable biological intervention in major depressive disorder (MDD) contributing to rapid symptom improvement. Molecular mechanisms underpinning the therapeutic effects of rTMS have still not been clarified. Recently published animal data implicated relevant associations with changes endocannabinoid (eCB) brain levels during treatment, human studies, however, published. In our study we assessed detailed phenotypic...
Abstract Decreased gamma activity has been reported both in children and adults with attention deficit/hyperactivity disorder (ADHD). However, while ADHD is a lifelong neurodevelopmental disorder, our insight into the associations of spontaneous band age limited, especially adults. Therefore, we conducted an explorative study to investigate trajectories resting adult patients ( N = 42) versus matched healthy controls 59). We investigated relationship (30–48 Hz) four right hemispheric...
Abstract Evidence suggests that depressive symptomatology is a consequence of network dysfunction rather than lesion pathology. We studied whole-brain functional connectivity using Minimum Spanning Tree as graph-theoretical approach. Furthermore, we examined in the Default Mode Network, Frontolimbic Network (FLN), Salience and Cognitive Control Network. All 183 elderly subjects underwent comprehensive neuropsychological evaluation 3 Tesla brain MRI scan. To assess potential presence...
Abstract: The authors present a case of neurosyphilis associated with predominant psychiatric symptoms. elderly man was admitted because confused behavior, maniform state, lack critical judgement and grandiose delusions. On admission, right central facial nerve paresis, hand tremor parkinsonism were also found. Acute brain imaging routine laboratory tests failed to identify firm etiology the confusional state. treatment resulted in complete recovery from delirium. Afterwards, psychosis...
Patients with schizophrenia are characterized by compromised working memory (WM) performance and increased distractibility. Theta synchronization (especially over the frontal midline areas) is related to cognitive control executive processes during WM encoding retention. Alpha event-related desynchronization (ERD) associated information processing attention.Participants (35 patients 39 matched controls) performed a modified Sternberg task, containing salient non-salient distractor items in...
Major symptoms evidenced by patients with Attention Deficit Hyperactivity Disorder (ADHD) have been linked to deficiencies in cognitive control, especially when conflicts information processing occur. We wanted define neural correlates of impairments conflict monitoring ADHD using the ERP technique. Unlike previous studies that focused on brain potentials following incorrect responses ADHD, we investigated a potential, N2, which reflects before correct response. Participants were 33 adult...
Introduction Emerging evidence suggests that disturbances in emotional processing ADHD may interfere with executive functioning, and account for impairments life functioning. Objective To investigate whether patients deficits emotionally-valenced inputs, to delineate the neurobiological correlates of these deficits. Methods Using event-related potentials from 128-channels, we tested 33 adult subjects 29 individually-matched healthy controls (HC) a cognitive control task response inhibition....
Abstract Our aim was to delineate the electrophysiological basis of dysfunctional inhibitory control adult ADHD via investigating anteriorization P3 component event-related brain response associated with NoGo task condition (i.e., anteriorization, NGA). NGA is a neurophysiological measure topography for cognitive control, which indexes an overall shift brain’s electrical activity in anterior direction towards prefrontal areas. While received considerable attention literature, this component,...
Introduction Impaired social cognition is a characteristic feature of schizophrenia, which associated with the level community functioning. Socioeconomic games are well-established in behavioral economy and widely used to examine decision-making strategies. They can also provide useful method investigation psychiatric diseases such as schizophrenia. The strength these compared classic paradigms that they allow observing subjects directly engaged interpersonal situations, thus real-time...
During drug development pharmaceutical manufacturers conduct numerous clinical trials to demonstrate therapeutic efficacy and safety of new antipsychotic candidates. However, are impacted by the need comply with scientific standards regulatory requirements for approval. While supplying information necessary approval, these provide data on a limited sample, obtained under conditions often removed from practice. Drug labeling containing warnings, precautions adverse events undergo regular...