A5013851784- Platelet Disorders and Treatments
- Extracellular vesicles in disease
- Blood groups and transfusion
- Blood transfusion and management
- Tuberculosis Research and Epidemiology
- T-cell and B-cell Immunology
- Inflammatory Biomarkers in Disease Prognosis
- Blood donation and transfusion practices
- Erythrocyte Function and Pathophysiology
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Mesenchymal stem cell research
- Hematopoietic Stem Cell Transplantation
- Blood properties and coagulation
- MicroRNA in disease regulation
- Hemoglobinopathies and Related Disorders
- Virus-based gene therapy research
- Complement system in diseases
- Reproductive System and Pregnancy
- vaccines and immunoinformatics approaches
- Diabetes and associated disorders
- Cytomegalovirus and herpesvirus research
- Bacteriophages and microbial interactions
- Heparin-Induced Thrombocytopenia and Thrombosis
- Ectopic Pregnancy Diagnosis and Management
High Institute for Education and Research in Transfusion Medicine
2015-2024
Kharazmi University
2022-2023
Islamic Azad University, Tehran
2021
University of Isfahan
2014
Iranian Legal Medicine Organization
2007-2011
Background Although apoptosis occurs in nucleated cells, studies show that this event also some anucleated cells such as platelets. During storage of platelets, the viability platelets decreased, lesions were observed, and underwent apoptosis. We investigated effects caspase-3 inhibitor on survival function after different periods storage. Methods Platelet concentrates obtained from Iranian Blood Transfusion Organization plastic blood bags. Caspase-3 (Z-DEVD-FMK) was added to These bags...
One of the most fascinating areas research within field histocompatibility at present time concerns an observation that a major human system, leucocyte antigen (HLA), is deeply involved in development great number diseases. Major complex polymorphic system genome different species. Recognition HLA alleles could be useful transplantation and disease studies. Genetic construct DRB1 was studied Iranian normal populations patients with aplastic anaemia Fanconi's disease. DNA extracted from whole...
Background: Various methods have been used to isolate red blood cell (RBC) membrane antigens. In this regard, obtaining the antigen and preserving its structure is of special importance. However, limited studies conducted purify cellular antigens such as Rh proteins. Materials Methods: experimental study, Rhc RBC was purified. Here, solubilized through lysis buffer. Next, dialysis affinity chromatography were performed using polyclonal anti-human RhCcEe antibody Rhc/e from RBCs with...
Human leucocyte antigen-G (HLA-G) is a non-classical HLA class I molecule that unlike the classical HLA, has low polymorphism. This molecule, initially, found on invasive trophoblast cells and postulated to have mediatory role in maternal-fetal interface. So far 43 alleles of HLA-G gene been found. Studies could be useful understanding genetic variants Iranian population. The goal this research was determine polymorphism healthy population Iran. Genomic DNA isolated from whole blood 102...
The in vitro treatment of tumor cells with platelet (Plt) causes inhibition cell growth, although mechanism this effect is not clear yet. Induction apoptosis has been proposed as a Plt effects on cells. purpose study was to clarify the role Plts and Plt-derived components induction blood mononuclear patients leukemia.In experimental study, peripheral (PBMCs) were isolated from whole five childhood B-precursor acute lymphoblastic leukemia (pre-B ALL) encountered Plts, microparticles (Plt-MPs)...
Tuberculosis (TB) remains one of the most afflictive bacterial infections globally. In high burden TB countries, surveillance, diagnosis and treatment drug resistant (RR X/MDRTB) display a crucial public health challenge. Therefore, we need new vaccines; diagnostic therapeutic strategies to briskly prevent disease promotion; reduce drug-resistant protect everyone from disease. The study identified various potent membrane cell wall M. tuberculosis glycolipoproteins that are relevant for...
Introduction: During recent years, the need for platelet concentrate (PC) has increased. Infusible membranes (IPM) have been developed as an alternative to standard PCs, with additional advantage of long shelf-life and increased viral safety. In this study, IPM construction morphological biological features these microvesicles were surveyed determine their binding capacities in vitro. Methods: Thirty-five PC units prepared by Iranian Blood Transfusion Organization used produce IPM. Platelets...