A5021378010- Cardiac electrophysiology and arrhythmias
- Fish Ecology and Management Studies
- Marine and fisheries research
- Cardiomyopathy and Myosin Studies
- Ichthyology and Marine Biology
- Ion channel regulation and function
- Physiological and biochemical adaptations
- Cardiovascular Function and Risk Factors
- Neuroscience and Neural Engineering
- Isotope Analysis in Ecology
- Marine animal studies overview
- Fish Biology and Ecology Studies
- Aquaculture Nutrition and Growth
- Marine Bivalve and Aquaculture Studies
- Identification and Quantification in Food
- Congenital heart defects research
- Cardiac Fibrosis and Remodeling
- Cardiovascular Effects of Exercise
- Genetic diversity and population structure
- Cardiac Arrhythmias and Treatments
- Coral and Marine Ecosystems Studies
- Morphological variations and asymmetry
- Paleontology and Evolutionary Biology
- Protein Kinase Regulation and GTPase Signaling
- Pluripotent Stem Cells Research
University of Oslo
2016-2025
Oslo University Hospital
2016-2025
Institutt for Eksperimentell Medisinsk Forskning
2016-2025
Stony Brook University
2014-2024
657 Oslo
2024
University of Copenhagen
2011-2023
University of Colorado Anschutz Medical Campus
2023
Lithuanian University of Health Sciences
2023
University of California, Davis
2023
Glostrup Hospital
2023
Human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM) are increasingly being used for modeling heart disease and under development regeneration of the injured heart. However, incomplete structural functional maturation hiPSC-CM, including lack T-tubules, immature excitation-contraction coupling, inefficient Ca-induced Ca release remain major limitations.Thyroid glucocorticoid hormones critical maturation. We hypothesized that their addition to standard protocols would promote...
Lost biomass of anadromous forage species resulting from the seventeenth to nineteenth century damming waterways and overharvest in northeastern United States contributed significant changes coastal marine—terrestrial ecosystems. Historic alewife populations Maine for years 1600–1900 were assessed using analyses twentieth harvest records waterway obstruction dating 1600s. Obstructed spawning access nine watersheds reduced annual productivity per watershed 0%–16% virgin estimates, equaling a...
Invaginations of the cellular membrane called t-tubules are essential for maintaining efficient excitation–contraction coupling in ventricular cardiomyocytes. Disruption t-tubule structure during heart failure has been linked to dyssynchronous, slowed Ca2+ release and reduced power heartbeat. The underlying mechanism is, however, unknown. We presently investigated whether elevated wall stress triggers remodelling function. MRI blood pressure measurements were employed examine regional across...
Reduced cardiac contractility during heart failure (HF) is linked to impaired Ca 2+ release from Ryanodine Receptors (RyRs). We investigated whether this deficit can be traced nanoscale RyR reorganization. Using super-resolution imaging, we observed dispersion of clusters in cardiomyocytes post-infarction HF rats, resulting more numerous, smaller clusters. Functional groupings which produce sparks (Ca units, CRUs) also became less solid. An increased fraction small CRUs was augmented...
Whereas heart failure with reduced ejection fraction (HFrEF) is associated ventricular dilation and markedly systolic function, preserved (HFpEF) patients exhibit concentric hypertrophy diastolic dysfunction. Impaired cardiomyocyte Ca2+ homeostasis in HFrEF has been linked to disruption of membrane invaginations called t-tubules, but it unknown if such changes occur HFpEF. This study examined whether distinct phenotypes underlie the entities T-tubule structure was investigated left biopsies...
Abstract Heart failure (HF) is a major cause of morbidity and mortality worldwide, highlighting an urgent need for novel treatment options, despite recent improvements. Aberrant Ca 2+ handling key feature HF pathophysiology. Restoring the regulating machinery attractive therapeutic strategy supported by genetic pharmacological proof concept studies. Here, we study antisense oligonucleotides (ASOs) as modality, interfering with PLN/SERCA2a interaction targeting Pln mRNA downregulation in...
Understanding the factors shaping patterns of ecological resilience is critical for mitigating loss global biodiversity. Throughout aquatic environments, highly mobile predators are thought to serve as important vectors energy between ecosystems thereby promoting stability and resilience. However, role these play in connecting food webs flow remains poorly understood most contexts. Using carbon nitrogen isotopes, we quantified use several prey resource pools (small oceanic forage, large...
CD38, a regulator of intracellular calcium signalling, is highly expressed in immune cells. Mice lacking CD38 are very susceptible to acute bacterial infections, implicating innate responses. The effects inhibition on NLRP3 inflammasome activation human primary monocytes and monocyte-derived macrophages have not been investigated. Apigenin naturally occurring flavonoid known inhibit CD38. However, apigenin has also proposed the extracellular ATP receptor P2XR7, an upstream activator NLRP3....
Although t-tubules have traditionally been thought to be absent in atrial cardiomyocytes, recent studies suggested that exist the atria of large mammals. However, it is unclear whether regional differences t-tubule organization define cardiomyocyte function across atria. We sought investigate density pig and rat consequences for Ca(2+) homeostasis. observed approximately one-third both tissue cryosections isolated cardiomyocytes. In a minority (≈10%) t-tubular network was well organized,...
As reactivation of the fetal gene program has been implicated in pathological remodelling during heart failure (HF), we examined whether cardiomyocyte subcellular structure and function revert to an immature phenotype this disease. Surface internal membrane structures appeared gradually development, returned a juvenile state HF. Similarly, dyadic junctions between cell sarcoplasmic reticulum were progressively 'packed' with L-type Ca2+ channels ryanodine receptors 'unpacked' Despite...
To prevent autoimmunity, thymocytes expressing self-reactive T cell receptors (TCRs) are negatively selected, however, divergence into tolerogenic, agonist selected lineages represent an alternative fate. As thymocyte development, selection, and lineage choices dependent on spatial context cell-to-cell interactions, we have performed Cellular Indexing of Transcriptomes Epitopes by sequencing (CITE-seq) transcriptomics paediatric human thymus. Thymocytes markers strong TCR signalling...
Over the past thirty years catches of skates have increased in western Atlantic as a result targeted fisheries and by-catch. Presently, sustainable harvest levels for are unknown. Available life history information was used to model three skate species, little Leucoraja erinacea , winter ocellata barndooor Dipturus laevis determine their population growth rate susceptibility decline under exploitation. Population characteristics were estimated using age-based matrix analyses stage-based...
Under certain conditions, a number of fish species may perform brief excursions into severe hypoxia and return to water with higher oxygen content. The term describes conditions that are below the critical saturation (S crit ), defined here as threshold at which standard metabolic rate becomes dependent upon ambient Using rainbow trout ( Oncorhynchus mykiss (Walbaum, 1792), this study quantified excess posthypoxic consumption (EPHOC) occurring after exposure availability S . Tests showed was...
Hypokalemia occurs in up to 20% of hospitalized patients and is associated with increased incidence ventricular atrial fibrillation. It unclear whether these differing types arrhythmia result from direct perhaps distinct effects hypokalemia on cardiomyocytes.To investigate proarrhythmic mechanisms myocytes.Experiments were performed isolated rat myocytes exposed simulated conditions (reduction extracellular [K+] 5.0 2.7 mmol/L) supported by mathematical modeling studies. Ventricular cells...
High pre-slaughter mortality rates of Atlantic salmon (Salmo salar L.) are a reoccurring welfare issue and economic burden in aquaculture. Sudden death immediately prior to slaughter is particularly problematic given the considerable resources invested reach this stage. Although underlying causes such largely unknown, cardiac deformities diseases have become increasingly prevalent observations deceased fish. The factors leading pathology remains be revealed. Thus, we presently examined if...
Marine protected areas (MPAs) have emerged as potentially important conservation tools for the of biodiversity and mitigation climate impacts. Among MPAs, a large percentage has been created with implicit goal protecting shark populations, including 17 sanctuaries which fully protect sharks throughout their jurisdiction. The Commonwealth Bahamas represents long-term MPA sharks, following banning commercial longlining in 1993 subsequent designation sanctuary 2011. Little is known, however,...
Transverse tubules (t-tubules) form gradually in the developing heart, critically enabling maturation of cardiomyocyte Ca2+ homeostasis. The membrane bending and scaffolding protein BIN1 (bridging integrator 1) has been implicated this process. However, it is unclear which various reported isoforms are involved, whether function regulated by its putative binding partners MTM1 (myotubularin), a phosphoinositide 3'-phosphatase, DNM2 (dynamin-2), GTPase believed to mediate fission.We...
An understanding of age-specific habitat requirements and the timing critical ontogenetic transitions is essential to informing conservation recovery efforts for Atlantic Sturgeon ( Acipenser oxyrinchus ). However, these are often difficult assess due species' cryptic nature consequent lack temporal spatial data across life stages. Sampling microchemistry analysis dorsal scute apical spines (i.e., scutes) represents an innovative methodology reconstruct past life-history events endangered...
Abstract Exercise‐induced muscle damage (EIMD) is characterized by a severe and prolonged decline in force‐generating capacity. However, the precise cellular mechanisms underlying observed long‐lasting capacity associated with EIMD are still unclear. We investigated vivo force generation ex Ca 2+ ‐activated generation, sensitivity, myofiber handling systems (SR t‐tubules) human biceps brachii before 2, 48, 96 h after eccentrically muscle‐damaging contractions non‐exercised control arm. The...