A5052694200- Developmental Biology and Gene Regulation
- Congenital heart defects research
- dental development and anomalies
- Silk-based biomaterials and applications
- Genomics and Chromatin Dynamics
- Animal Genetics and Reproduction
- Zebrafish Biomedical Research Applications
- Cell Adhesion Molecules Research
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Proteoglycans and glycosaminoglycans research
- Cancer-related molecular mechanisms research
Gyeongsang National University
2019-2025
The hyomandibular (HM) cartilage securing the lower jaw to neurocranium in fish is a craniofacial skeletal element whose shape and function have changed dramatically vertebrate evolution, yet genetic mechanisms shaping this are less understood. Using mutants rescue experiments zebrafish, we reveal previously unappreciated role of Pax1a anterior HM plate formation through EphrinB2a. During development, pax1a expressed pharyngeal endoderm from segmentation stage chondrocyte formation. Loss...
Thehead gap gene buttonhead (btd) is required for the patterning of head segments in early Drosophila embryo. Mutant phenotypes btd display a gap-like phenotype which antennal, intercalary, mandibular and anterior portion maxillary segmentsare eliminated. In agreement with phenotypes, expressed stripe covering at blastoderm stage. During phase germband extension, stripes single segmental periodicity, formation peripheral nervous system. contrast to key role embryonic development, it has been...
Epidermal growth factor-like domain multiple 6 (Egfl6) is a basement membrane protein and plays an important role in hair follicle morphogenesis, angiogenesis, notochord development vertebrates. Although egfl6 expression the developing head was observed zebrafish, its for craniofacial determination of pharyngeal region expressing egfl6, have not been reported yet. Here, we report patterns function zebrafish. expressed sequentially pouches that are key epithelial structures governing...
Pharyngeal pouches, a series of outgrowths the pharyngeal endoderm, are key epithelial structure governing facial skeleton development in vertebrates. Pouch formation is achieved through collective cell migration and rearrangement pouch-forming cells controlled by actin cytoskeleton dynamics. While essential transcription factors signaling molecules have been identified pouch formation, regulators dynamics not reported yet any Cofilin1-like (Cfl1l) fish-specific member Actin-depolymerizing...