A5027393837- Nanoparticle-Based Drug Delivery
- Antimicrobial agents and applications
- Advanced Drug Delivery Systems
- Nanoplatforms for cancer theranostics
- RNA Interference and Gene Delivery
- Essential Oils and Antimicrobial Activity
- Nanotechnology research and applications
- Antimicrobial Peptides and Activities
- Advanced biosensing and bioanalysis techniques
- Graphene and Nanomaterials Applications
- Nanoparticles: synthesis and applications
- Analytical Chemistry and Chromatography
- Antibiotics Pharmacokinetics and Efficacy
- Skin Protection and Aging
- Extracellular vesicles in disease
- Advancements in Transdermal Drug Delivery
- Genetics, Aging, and Longevity in Model Organisms
- Drug Solubulity and Delivery Systems
- Lipid Membrane Structure and Behavior
- Surfactants and Colloidal Systems
- Enzyme Catalysis and Immobilization
- COVID-19 and Mental Health
- Aquatic life and conservation
- Aquaculture Nutrition and Growth
- Bacterial biofilms and quorum sensing
Universidade Federal do Rio Grande do Sul
2016-2023
Universidade Paranaense
2022
Galleria mellonella larvae is an invertebrate that has been extensively used as experimental model in the investigation of microbial virulence and efficacy antimicrobial agents can be to provide faster cheaper data than traditional test systems. Our objective was propose use G. In Vivo evaluate toxicity lipid-core nanocapsule (LNC) formulations having different surface coatings. Blank LNC were coated with polysorbate 80 (LNC-1), lecithin (LNC-2), lecithin, chitosan (LNC-3). Subsequently,...
The oral route is the best way to administer a drug; however, fitting peptide drugs in this major challenge. In insulin cases, less than 0.5% of administered dose achieves systemic circulation. Oral delivery by nanoparticles can increase permeability across intestinal epithelium while maintaining its structure and activity until release gut. This system be improved cells through active delivery. study aimed improve nanoparticle formulation promoting functionalization surface with...
Nanotechnology is a rapidly evolving interdisciplinary field with vast potential applications across various sectors, including medicine, electronics, and energy. Its integration into education presents both opportunities challenges. To effectively teach nanotechnology, educators must foster knowledge-centered learning environments, promote approaches, provide early exposure to scientific research. Despite the increasing recognition of nanotechnology's importance, its successful curricula...
Aim: To evaluate the antitumor efficacy of bevacizumab-functionalized nanocapsules in a rat glioblastoma model after pretreatment with functionalized peptide-specific to epidermal growth factor receptor variant III. Materials & methods: Nanocapsules were prepared, physicochemical characterized and intranasally administered rats. Parameters such as tumor size, histopathological characteristics infiltration CD8+ T lymphocytes evaluated. Results: The strategy treatment resulted reduction 87%...
Glioblastoma (GB) is a histological and genetically heterogeneous brain tumor that highly proliferative vascularized. The prognosis poor with currently available treatment. In this study, we evaluated the cytotoxicity antiangiogenic activity of doxorubicin-loaded-chitosan-coated-arginylglycylaspartic acid-functionalized-poly(ε-caprolactone)-alpha bisabolol-LNC (AB-DOX-LNC-L-C-RGD). nanoformulation was prepared by self-assembling followed interfacial reactions, physicochemically characterized...
A set of synthetic data, antibacterial evaluation against gram-positive bacteria, as well as, the interaction bacterial with lipid-core nanocapsules containing fusidic acid is presented here. In this data set, analytical are detailed; serial microdilution; nanoparticle tracking analysis; transmission electron microscopy; minimum inhibitory concentration; diameter size and zeta potential, infra-red formulations before after contact bacteria.
Analytical techniques are critical for ensuring physical and chemical stability of a drug both assessing the molecules quantifying identifying content in products. We proposed development dry-powders lipid-core nanocapsules containing dapsone coated with chitosan, as well as, analytical quantification 1% 2% (m/v) leucine by high-performance liquid chromatography (HPLC). Size is most relevant physicochemical property nanoparticulated delivery systems. In this context, our results demonstrated...
Mesmo em tempos modernos, os grandes avanços tecnológicos não permitem de forma comprovada retardar o envelhecimento nos seres humanos. Neste sentido, uma das estratégias é uso moléculas químicas naturais que possuem a ação ativadores telomerase, vez telomerase ribonucleoproteína transcriptase reversa possui função alongar telômeros e neutralizar erosão normal dos telômeros. contexto, este estudo revisão dedicou-se aprofundar conhecimento sobre derivadas plantas para atividade anti-aging....
Introdução: As drogas psicotrópicas tornaram-se cada vez mais significativas durante a pandemia de COVID-19 devido à sua eficácia no tratamento sintomas neuropsiquiátricos. Objetivos: Esta revisão da literatura visa explorar combinação vortioxetina, cetamina, bromazepam e alprazolam depressão associada ao COVID-19. Metodologia: O estudo adota uma abordagem pesquisa qualitativa quantitativa. Pesquisas bibliográficas foram realizadas em bancos dados científicos, incluindo PUBMED, web of...
We developed a solid formulation of calcium alginate beads containing paclitaxel-loaded lipid-core nanocapsules (PTX-LNC-Bead) intended for oral administration. The PTX-LNC liquid was prepared by interfacial deposition and trapped into beads. These were characterized in terms size, morphology, swelling rate, encapsulation efficiency, release PTX LNC simulated gastrointestinal fluids. Results showed that the gastro-resistant with low rate drug lower than 3.5% at pH 1.2 (2h). At 6.8, high...