A5031335895- Pharmaceutical Economics and Policy
- Health Systems, Economic Evaluations, Quality of Life
- Pharmaceutical industry and healthcare
- Pharmaceutical studies and practices
- Parkinson's Disease Mechanisms and Treatments
- Biosimilars and Bioanalytical Methods
- Medication Adherence and Compliance
- Medical Malpractice and Liability Issues
- Healthcare Policy and Management
- Public Health in Brazil
- Lysosomal Storage Disorders Research
- Biomedical Ethics and Regulation
- Pharmaceutical Practices and Patient Outcomes
- Genetic Neurodegenerative Diseases
- Intellectual Property and Patents
- Healthcare cost, quality, practices
- Prenatal Substance Exposure Effects
- Neurogenetic and Muscular Disorders Research
- Biotechnology and Related Fields
- Diabetes Treatment and Management
- Autism Spectrum Disorder Research
- Primary Care and Health Outcomes
- Cannabis and Cannabinoid Research
- Neurological disorders and treatments
- Pesticide Exposure and Toxicity
Johns Hopkins University
2016-2025
University of Maryland, College Park
2020
University of York
2020
Cal Humanities
2020
Hospital de Clínicas de Porto Alegre
2006-2011
Princeton University
2010
Universidade Federal do Rio Grande do Sul
2001-2008
Universidade de São Paulo
2007
University of Turin
2007
Erasmus MC
2007
To assess the prevalence, nature, and associated phenotypes of ATP13A2 gene mutations among patients with juvenile parkinsonism (onset <21 years) or young onset (between 21 40 Parkinson disease (YOPD).We studied 46 patients, mostly from Italy Brazil, including 11 35 YOPD. Thirty-three cases were sporadic 13 had positive family history compatible autosomal recessive inheritance. Forty-two only parkinsonian signs, while four (all juvenile-onset) multisystemic involvement. The whole coding...
This Viewpoint offers strategies for addressing shortages in essential chemotherapeutic drugs.
Abstract Naloxone is an opioid antagonist that can reverse overdoses and save lives. In 2023, the California Department of Health Care Access Information mobilized its affordable drug manufacturing program, CalRx, to develop a more naloxone nasal product could help increase access for all Californians. Partnering with new market entrant, CalRx offered stable demand forecast initial 3-year agreement. exchange, selected manufacturer launched generic over-the-counter at transparent price 40%...
The US supply of generic drugs is heavily dependent on the global chain for sources active pharmaceutical ingredients (APIs) market. Data from Clarivate Analytics' Cortellis Generics Intelligence database were analyzed to perform a systematic examination APIs produced globally market during 2020-21. We identified total 565 facilities producing 1,379 unique across forty-two countries. India, China, and Italy top producers; 14 percent manufactured in US. About third by single facility, another...
This paper quantifies the impact of horizontal mergers on prices drugs. We study all between two publicly traded pharmaceutical companies working in US 2010 and 2015 their effect drugs prices. Using a differences-in-differences approach, we estimate that marketed by merging firms experience an AWP increase about 8% 15% during five years following merger. These price increases are present even markets with more than competitors.
Multiple studies have suggested that various pesticides are associated with a higher risk of developing Parkinson's disease (PD) and may influence the progression disease. However, evidence regarding impact pesticide exposure on mortality among patients PD is equivocal. This study examines whether influences in Southern Brazil.A total 150 idiopathic were enrolled from 2008 to 2013 followed until 2019. In addition undergoing detailed neurologic evaluation, completed surveys socioeconomic...
Importance Nonprofit hospitals are under increasing scrutiny to justify the generous tax benefit they receive due their tax-exempt status. Quantifying value of at federal, state, and local levels is critical for designing informed public health policies ensuring nonprofit hospitals’ taxpayer accountability. Objective To estimate financial that derive from status assess how distributed across state communities. Design, Setting, Participants Using methodologies measures consistent with current...
There is a lack of evidence on the clinical efficacy and safety recently released Chinese botulinum toxin serotype A (Prosigne) for treatment focal dystonias hemifacial spasm. Determining more precise role Prosigne in such conditions paramount importance, because type treatments have huge economic implication health services, especially developing countries. The aim our study was to compare blepharospasm spasm comparison Botox. We performed double-blind, randomized, crossover enrolling 26...
Many countries use external reference pricing to help determine drug prices. However, has received little attention in the US-perhaps because US is often first adopter of drugs. External could be used set prices for drugs that were already established market. We compared price differentials between and UK, Japan, Ontario (Canada) single-source brand-name had been on market at least three years. found averaged 3.2-4.1 times higher after rebates considered. The differential individual varied...
This study examines Medicare Part D prescription drug plans to assess how often branded products were given more favorable formulary placement than generic products.
Background. Prognosis of PD is variable. Most studies show higher mortality rates in patients compared to the general population. Clinical and epidemiologic factors predicting are poorly understood. Methods. features including patient history physical, functional, cognitive scores were collected from a hospital-based cohort using standardized protocols clinical scales. Data on comorbidities follow-up. Results. During mean follow-up 4.71 years (range 1-10), 43 (20.9%) 206 died. Those who died...
Background: On April 1, 2016, the Centers for Medicare & Medicaid Services (CMS) introduced bundled-payment programs hip replacement and knee (HKR) in selected metropolitan statistical areas (MSAs) to decrease costs cost variability of HKR increase quality care. Early program analyses showed savings; however, studies also demonstrated a trend toward selection healthier patients performed under bundled system. We compared characteristics who underwent before implementation system...
The U.S. Food and Drug Administration provides accelerated approval to drugs on the basis of surrogate end points deemed be "reasonably likely" predict clinical benefit. To receive full approval, must complete a confirmatory trial. Although most approved ultimately others remain market without for many years, some are withdrawn before is granted. Until trials completed granted, there uncertainty surrounding each drug's benefits.To estimate fee-for-service Medicare payments...
Gene and RNA therapies are promising treatments for many rare diseases. Pediatric populations that could benefit from these drugs overrepresented among state Medicaid programs. Using State Drug Utilization Data, we examined spending utilization of disease gene therapies. Between 2017 2022, the number available increased 3 to 13, yearly $148.3 million $879.7 million, (a proxy patients) 327 1638. Nearly all was attributed spinal muscular atrophy (SMA) Duchenne dystrophy drugs. States...