A5102764847- melanin and skin pigmentation
- Skin Protection and Aging
- Biochemical Analysis and Sensing Techniques
- Atherosclerosis and Cardiovascular Diseases
- Telomeres, Telomerase, and Senescence
- Olfactory and Sensory Function Studies
- Pharmacological Effects of Natural Compounds
Air Force General Hospital PLA
2021-2025
Abstract Background The total glucoside of paeony (TGP) is recognized for its immunomodulatory properties and anti‐inflammatory effects. This study evaluates the efficacy TGP combined with oral mini‐pulse therapy (OMP) narrow‐band ultraviolet B (NB‐UVB) in treating active nonsegmental vitiligo (NSV). Materials methods combination was contrasted against those from a group treated solely OMP NB‐UVB. Data 62 patients undergoing treatment 55 without were analyzed over 3‐month period. After 6...
Vitiligo is a challenging chronic condition with unpredictable disease course and high propensity for relapse post-treatment. Recent studies have reported the biomarkers activity, severity, therapeutic response of vitiligo, yet very few investigated cytokines as predictive recurrence in vitiligo. This study aims to explore that serve extend research on factors related disease's activity. 92 patients 40 healthy controls were recruited at Air Force Medical Center from September 20, 2023,...
Background . Oxidative stress has a vital role in the early stages of vitiligo. Autoantigens released from apoptotic melanocytes (MC) under oxidative are involved presentation and recognition antigens. However, transport autoantigens to cell surface their release extracellular environment still unclear. Apoptotic bodies (ABs) have always been considered as key source immunomodulators autoantigens. Yet, ABs immune mechanism vitiligo is unknown. Purpose To explore whether MC’s translocate into...
Vitiligo is a chronic autoimmune disease manifested by depigmented patches of skin devoid melanocytes. Baricitinib, JAK inhibitor selectively targeting JAK1/2, has shown preliminary efficacy for vitiligo. We aimed to assess the and tolerability combination therapy with baricitinib narrowband UV-B (NB-UVB) treat active nonsegmental vitiligo (NSV).
Vitiligo is a depigmentation disorder characterized by the loss of melanocytes in skin, which aggravated oxidative stress. The relationship between stress and cellular senescence still unclear despite considerable research on melanocyte vitiligo recent years. Many chronic diseases associated with stress, that is, degenerative diseases, have been shown to ultimately result due sustained activation reactive oxygen species. This study advances pathophysiology its treatment options summarizing...