A5052507675- RNA and protein synthesis mechanisms
- RNA modifications and cancer
- Military and Defense Studies
- RNA Research and Splicing
- Policing Practices and Perceptions
- Military, Security, and Education Studies
- Hungarian Social, Economic and Educational Studies
- Border Security and International Relations
- Ukrainian Legal and Forensic Studies
- Insurance and Financial Risk Management
- Ombudsman and Human Rights
Czech Academy of Sciences, Institute of Molecular Genetics
2021-2023
Czech Academy of Sciences
2021-2023
University of Novi Sad
2013-2021
Abstract Spliceosomal snRNPs are multicomponent particles that undergo a complex maturation pathway. Human Sm-class snRNAs generated as 3′-end extended precursors, which exported to the cytoplasm and assembled together with Sm proteins into core RNPs by SMN complex. Here, we provide evidence these pre-snRNA substrates contain compact, evolutionarily conserved secondary structures overlap binding site. These structural motifs in pre-snRNAs predicted interfere assembly. We model rearrangements...
Abstract U5 snRNP is a complex particle essential for RNA splicing. snRNPs undergo intricate biogenesis that ensures only fully mature assembles into splicing competent U4/U6•U5 tri-snRNP and enters the reaction. During splicing, substantially rearranged leaves as U5/PRPF19 post-splicing particle, which requires re-generation before next round of Here, we show previously uncharacterized protein TSSC4 component promotes formation. We provide evidence associates with chaperones, particle....
Even though security services have the same function as before, today they different tasks and significantly more work than before. Modern problems of late 20th early 21st century require states to reorganize their services, adapting them new changes. The reorganization involves, among other things, giving wider powers in order effectively counter growing sophisticated threats, which may also lead violations human rights freedoms. It is therefore necessary define right competence,...
Control as a function of management in the police is accompanied by numerous problems, which are mainly related to process itself. One these problems specific subculture police. Subculture occurs, among other, result tightness police, within values, attitudes and behaviors developed. This particularly evident relation manager-subordinate. In fact, practice it often happens that managers subordinates unsympathetically look at each other. On other hand, great solidarity between can lead...