A5105939404- Genetics and Neurodevelopmental Disorders
- Autism Spectrum Disorder Research
- Congenital heart defects research
- Hemispheric Asymmetry in Neuroscience
- Williams Syndrome Research
- Cognitive Abilities and Testing
- Psychoanalysis and Psychopathology Research
- Genomic variations and chromosomal abnormalities
- Down syndrome and intellectual disability research
- Education, sociology, and vocational training
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Children's Physical and Motor Development
- Dermatoglyphics and Human Traits
- Assisted Reproductive Technology and Twin Pregnancy
- Cerebral Palsy and Movement Disorders
- Genetics, Bioinformatics, and Biomedical Research
- Neuroendocrine regulation and behavior
- Race, Genetics, and Society
- Cognitive and developmental aspects of mathematical skills
- Genomics and Rare Diseases
- Psychological and Educational Research Studies
- Health, Medicine and Society
- Child and Animal Learning Development
- Genetic Mapping and Diversity in Plants and Animals
- Spatial Cognition and Navigation
Laboratoire de Psychologie Cognitive
2009-2022
Aix-Marseille Université
2010-2021
Centre National de la Recherche Scientifique
2010-2021
Institute of Human Genetics
2012-2014
Columbia College - Missouri
2012-2014
Amsterdam University of Applied Sciences
2012-2014
The University of Adelaide
2012-2013
Institut Universitaire de France
1999-2012
Institut de France
2006-2008
Université Paris Cité
1978-2004
Microdeletions of the 22q11 region, responsible for velo-cardio-facial syndrome (VCFS), are associated with an increased risk psychosis and mental retardation.Recently, it has been shown in a hyperprolinemic mouse model that interaction between two genes localized hemideleted proline dehydrogenase (PRODH ) catechol-o-methyl-transferase (COMT ), could be involved this phenotype.Here, we further characterize eight children molecular basis type I hyperprolinemia (HPI), recessive disorder...
Embryo cryopreservation does not induce clear-cut anomalies at detectable rates, but several mechanisms exist for nonlethal damage during the freeze-thaw process, and risk of moderate or delayed consequences has been extensively investigated. In a long-term study including senescence, we compared cryopreserved control mice quantitative traits. Significant differences were seen in morphophysiological behavioral features, some them appearing elderly subjects. Thus, apart from its immediate...
Background Stigmatization is one of the greatest obstacles to successful integration people with Trisomy 21 (T21 or Down syndrome), most frequent genetic disorder associated intellectual disability. Research on attitudes and stereotypes toward these still focuses explicit measures subjected social-desirability biases, neglects how variability in facial stigmata influences stereotyping. Methodology/Principal Findings The participants were 165 adults including 55 young adult students,...
Williams-Beuren syndrome (WBS), a rare developmental disorder caused by deletion of contiguous genes at 7q11.23, has been characterized strengths in socialization (overfriendliness) and communication (excessive talkativeness). WBS often considered as the polar opposite behavioral phenotype to autism. Our objective was better understand range phenotypic expression relationship between autistic disorder.The study conducted on 9 French individuals aged from 4 37 years old with associated WBS....
Abstract The sexual dimorphism of aggression has led to a search for its Y chromosomal correlates. We have previously confirmed that initiation attack behavior against conspecific male is Y-dependent in two strains laboratory mice (NZB and CBA/H). provide evidence the non-pseudoautosomal region not involved only pseudoautosomal correlated with behavior. autosomal correlates also contribute this an additive or interactive manner
Abstract The aim of the study was validation Bishop's reaching card test (Bishop et al., 1996) in a French population. Annett's peg-moving (1985) and Purdue pegboard (Tiffin, 1948) were also used to assess manual performance. Subgroups left- right-handers established according preference as measured by questionnaire (1985). A sample 260 adults tested, including 158 self-professed right-handers, 77 left-handers, 25 ambidextrous people. three performance tests presented good metric qualities...
Abstract Two parental strains of laboratory mice, NZB and CBA/H, were chosen for their differences in attack behavior. have higher scores than CBA/H. An effect the Y chromosome on behavior was determined two maternal environments. Each male tested once a dyadic encounter with an A/J as standard opponent. The reciprocal F1s four backcrosses used. In each group, proportion attacking males used dependent variable. first experiment, ovarian graft method to test variation overall environment: vs....
Deletion of the Williams-Beuren syndrome (WBS) critical region (WBSCR), at 7q11.23, causes a developmental disorder commonly characterized by hypersociability and excessive talkativeness often considered opposite behavioral phenotype to autism. Duplication WBSCR leads severe delay in expressive language. Gene–dosage effects on language development 7q11.23 have been hypothesized. Molecular characterization was performed fluorescence situ hybridization high-resolution single-nucleotide...
Hand performance and laterality scores on a unimanual tapping test were studied in relation to age, sex, handedness sample of 209 French children. Each child performed three trials with each hand. Older children faster, but differences between hands not related age. Right-handed girls more lateralized than right-handed boys. Left- right-handers could be differentiated clearly by speed variability tapping. A subsample 36 retested estimate reliability. The coefficients high, especially when...
Children with trisomy 21 display atypical manual skills that change to some extent during development. We examined grasp characteristics and their development in 35 children 21, aged 4-18 years, who performed simple tasks (two of the Movement Assessment Battery for Children, grasping five wooden blocks whose size was determined by hand size). The age-matched comparison group included typically developing children. were found use fewer fingers than each task. They also used specific grasps...