A5080333939- EEG and Brain-Computer Interfaces
- Peptidase Inhibition and Analysis
- Neural dynamics and brain function
- Functional Brain Connectivity Studies
- Cell Adhesion Molecules Research
- Radiopharmaceutical Chemistry and Applications
- HER2/EGFR in Cancer Research
- Monoclonal and Polyclonal Antibodies Research
- Calcium signaling and nucleotide metabolism
- Multiple Myeloma Research and Treatments
- Chronic Lymphocytic Leukemia Research
- Neurobiology of Language and Bilingualism
- Epilepsy research and treatment
- Advanced MRI Techniques and Applications
- Neuroscience and Music Perception
- Glycosylation and Glycoproteins Research
- Neuroscience and Neural Engineering
- Advanced Neuroimaging Techniques and Applications
- Blind Source Separation Techniques
- Autism Spectrum Disorder Research
- Carbohydrate Chemistry and Synthesis
- Phonetics and Phonology Research
- Reading and Literacy Development
- Enzyme Structure and Function
- Neuroscience and Neuropharmacology Research
Helen DeVos Children's Hospital
2021-2024
Michigan State University
2022-2024
Corewell Health
2024
Google (United States)
2024
Corewell Health Blodgett Hospital
2021-2023
Spectrum Health
2021-2023
Sanofi (France)
2011-2023
The University of Texas at Austin
2015-2021
Dell Children's Medical Center of Central Texas
2017-2020
Great Ormond Street Hospital
2015
The CD38 cell surface antigen is expressed in diverse hematologic malignancies including multiple myeloma, B-cell non-Hodgkin lymphoma (NHL), chronic lymphocytic leukemia, acute lymphoblastic leukemia (ALL), and T-cell ALL. Here, we assessed the antitumor activity of anti-CD38 antibody SAR650984.Activity SAR650984 was examined on lymphoma, myeloma lines, primary samples, xenograft models immunodeficient mice.We identified a humanized with strong proapoptotic independent cross-linking agents,...
The human motor cortex exhibits transient bursts of high frequency gamma oscillations in the 60-90 Hz range during movement. It has been proposed that generally reflect local intracortical activity. However, movement-evoked is observed simultaneously both cortical and subcortical (basal ganglia) structures thus appears to long-range cortical-subcortical interactions. Recent evidence suggests do not simply sensory reafference, but have a facilitative role movement initiation. Here we...
Speech production is a hierarchical mechanism involving the synchronization of brain and oral articulators, where intention linguistic concepts transformed into meaningful sounds. Individuals with locked-in syndrome (fully paralyzed but aware) lose their motor ability completely including articulation even eyeball movement. The neural pathway may be only option to resume level communication for them. Current brain-computer interfaces (BCIs) use patients' visual attentional correlates build...
ABSTRACT OBJECTIVE To determine whether low-grade gliomas contain functional cortical activity more often than high-grade within radiologically defined abnormal tissue. METHODS Patients with intra-axial cerebral lesions located in the vicinity of eloquent brain cortex preoperatively underwent magnetic source imaging. A dual 37-channel biomagnetometer was used to perform Evoked fields were analyzed using single-equivalent dipole representation ascertain neuronal source. Stimuli included...
Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) is a glycoprotein that has limited expression in normal adult tissues, but overexpressed carcinomas of the gastrointestinal tract, genitourinary and respiratory systems, breast cancer. As such, CEACAM5 an attractive target for antibody-based therapies designed to selectively deliver cytotoxic drugs certain epithelial tumors. Here, we describe preclinical data novel antibody-drug conjugate (ADC), SAR408701, which consists...
Object. The aim of this study was to compare quantitatively the methods preoperative magnetic source (MS) imaging and intraoperative electrophysiological cortical mapping (ECM) in localization sensorimotor cortex patients with intraaxial brain tumors. Methods. Preoperative magnetoencephalography (MEG) performed while received painless tactile somatosensory stimulation lip, hand, foot. early evoked field modeled using a single equivalent current dipole approach estimate spatial response....
Abstract Chronic inflammation represents a central component in the pathogenesis of Alzheimer's disease (AD). Recent work suggests that breaking immune tolerance by Programmed cell Death‐1 (PD1) checkpoint inhibition produces an IFN‐γ‐dependent systemic response, with infiltration brain peripheral myeloid cells and neuropathological as well functional improvements even mice advanced amyloid pathology (Baruch et al., ( ): Nature Medicine, 22:135–137). Immune was therefore suggested potential...
Bispecific immunoglobulins (Igs) typically contain at least two distinct variable domains (Fv) that bind to different target proteins. They are conceived facilitate clinical development of biotherapeutic agents for diseases where improved outcome is obtained or expected by combination therapy compared treatment single agents. Almost all existing formats linear in their concept and differ widely drug-like manufacture-related properties. To overcome major limitations, we designed cross-over...
The phosphoglucosamine mutase (GlmM) from Escherichia coli , specifically required for the interconversion of glucosamine‐6‐phosphate and glucosamine‐1‐phosphate (an essential step in pathway cell‐wall peptidoglycan lipopolysaccharide biosyntheses) was purified to homogeneity its kinetic properties were investigated. enzyme active a phosphorylated form catalysed reaction according classical ping‐pong bi‐bi mechanism. dephosphorylated forms GlmM could be separated by HPLC coupled MS showed...
This study investigated the 50 ms (M50) and 100 (M100) components of auditory evoked field to explore their change during development. Using MEG, neuromagnetic fields elicited by a 1 kHz sinusoidal tone were recorded in adults two groups children adolescents with typical development or autism spectrum disorder. M50 amplitude was larger than adults, suggesting developmental trajectory decreasing M100 increasing age. Child latencies prolonged relative adults. Children did not differ from...
We have developed a novel assay specific to MraY, which catalyzes the first membrane step in biosynthesis of bacterial cell wall peptidoglycan. This was accomplished by using UDP-MurNAc-N(epsilon)-dansylpentapeptide, fluorescent derivative MraY nucleotide substrate, and partially purified preparation solubilized from membranes an Escherichia coli overproducing strain. Two versions were developed, one consisting high-pressure liquid chromatography separation substrate product (dansylated...
A novel class of heat shock protein 90 (Hsp90) inhibitors was developed after a low throughput screen (LTS) focused library containing approximately 21K compounds selected by virtual screening. The initial [1-{3-H-imidazo[4–5-c]pyridin-2-yl}-3,4-dihydro-2H-pyrido[2,1-a]isoindole-6-one] (1) compound showed moderate activity (IC50 = 7.6 μM on Hsp82, the yeast homologue Hsp90). high-resolution X-ray structure shows that 1 binds into an "induced" hydrophobic pocket, 10–15 Å away from...
Direct decoding of speech from the brain is a faster alternative to current electroencephalography (EEG) speller-based brain-computer interfaces (BCI) in providing communication assistance locked-in patients. Magnetoencephalography (MEG) has recently shown great potential as non-invasive neuroimaging modality for neural decoding, owing part its spatial selectivity over other high-temporal resolution devices. Standard MEG systems have large number cryogenically cooled channels/sensors (200 -...
The serotonin metabolism was extensively studied in 22 couples of autistic children and age- sex-matched controls. Histamine, calcium, uric acid were also measured urine whole blood or plasma. Autistics controls did not differ histamine, only minor changes noticed calcium content. According to previous reports, levels often, but always, evelated the children. Based on data including urinary 5-hydroxyindoleacetic acid, platelet uptake efflux, monoamine oxidase glutathione perixodase...
Human action involves a combination of controlled and automatic behavior. These processes may interact in tasks requiring rapid response selection or inhibition, where temporal constraints preclude timely intervention by conscious, over automatized prepotent responses. Such contexts tend to produce frequent errors, but also rapidly executed correct responses, both which sometimes be perceived as surprising, unintended, "automatic". In order identify neural underlying these two aspects...
BrainWave is an easy-to-use Matlab toolbox for the analysis of magnetoencephalography (MEG) data. It provides a graphical user interface performing minimum-variance beamforming with rapid and interactive visualization evoked induced brain activity. This article overview main features step-by-step demonstration how to proceed from raw experimental data group source images time series analyses. includes selection pre-processing, magnetic resonance image (MRI) co-registration normalization...
The aim of this study was to compare quantitatively the methods preoperative magnetic source (MS) imaging and intraoperative electrophysiological cortical mapping (ECM) in localization sensorimotor cortex patients with intraaxial brain tumors.Preoperative magnetoencephalography (MEG) performed while received painless tactile somatosensory stimulation lip, hand, foot. early evoked field modeled using a single equivalent current dipole approach estimate spatial response. Three-dimensional...