A5001199704- Gut microbiota and health
- Enterobacteriaceae and Cronobacter Research
- DNA Repair Mechanisms
- Radioactivity and Radon Measurements
- Geochemistry and Geologic Mapping
- Effects of Radiation Exposure
- Pleural and Pulmonary Diseases
- Pediatric health and respiratory diseases
- Probiotics and Fermented Foods
- Human Health and Disease
- Carcinogens and Genotoxicity Assessment
- Air Quality and Health Impacts
- Helicobacter pylori-related gastroenterology studies
- Occupational and environmental lung diseases
- Head and Neck Cancer Studies
- Mycobacterium research and diagnosis
- Medical and Biological Ozone Research
- Atmospheric and Environmental Gas Dynamics
- Cancer Cells and Metastasis
- Regional Economic Development and Innovation
- Radioactive contamination and transfer
- Business Strategy and Innovation
- Epigenetics and DNA Methylation
- Radiation Dose and Imaging
- Pneumothorax, Barotrauma, Emphysema
Kemerovo State University
2018-2025
The study of the influence geological structure (e.g., faults) on radon emanations is usually applicable provided that there are conditionally background (control) territories with which indicators will be compared. In presented study, we selected an area where pre-Cenozoic faults could potentially associated hazard Kuznetsk coal basin were not identified. cover deposits in represented by loamy and clayey strata overlying Paleozoic sedimentary cycles. field was estimated based flux density...
Abstract Here we report a pilot-sized study to compare the taxonomic composition of sputum microbiome in 17 newly-diagnosed lung cancer (LC) patients and controls. Another object was representation individual bacterial genera species with frequency chromosomal aberrations blood lymphocytes LC Both groups were male; average age 56.1 ± 11.5 55.7 4.1 Differences communities controls significant (pseudo-F = 1.94; p 0.005). Increased prevalence detected for Haemophilus Bergeyella ; whereas...
Recent studies have shown that the bacterial microbiome of respiratory tract influences development lung cancer. Changes in composition are observed patients with chronic inflammatory processes. Such changes may include occurrence bacteria cause oxidative stress and capable causing genome damage cells host organism directly indirectly. To date, various histological variants cancer has not been studied. In present study, we determined taxonomic sputum 52 squamous cell carcinoma lung,...
Geographic patterns determine geogenic radon factors that, changing over the territory, form spatial structures of different scales associated with regional and local variations. The study these is important for assessing possibility using limited data to predict potential. Our research focuses on physical properties soils (moisture, soil density, porosity void ratio) in Kuznetsk coal basin. Their variations are studied statistical methods, a variogram cloud autocorrelation data. Soil...
Recent findings indicate that the microbiome may have significant impact on development of lung cancer by its effects inflammation, dysbiosis or genome damage. The aim this study was to compare sputum (LC) patients with chromosomal aberration (CA) and micronuclei (MN) frequency in peripheral blood lymphocytes. In study, taxonomic composition 66 men untreated LC were compared 62 control subjects respect CA MN centromere fluorescence situ hybridisation analysis. Results showed a increase (4.11...
Recent findings indicate that the host microbiome can have a significant impact on development of lung cancer by inducing an inflammatory response, causing dysbiosis, and generating genome damage. The aim this study was to search for bacterial communities specifically associated with squamous cell carcinoma (LUSC).In study, taxonomic composition sputum 40 men untreated LUSC compared healthy controls. Next-Generation sequencing 16S rRNA genes used determine respiratory microbiome.There were...
The study specifies the changes in radon activity concentration (RAC) soil gas with depth and emphasizes significance of meteorological factor for deeper boreholes. Radon was measured 0.6 m, 1 m 1.5 boreholes, gradient also calculated. Spatial patterns were estimated using an autocorrelation index. RAC ranged from 9454 ± 439 Bq/m3 16,031 602 22,049 937 m. increased at most sites behaved quite uniformly spatial terms. At same time, no significant differences uranium (238U) series isotopes...
This study is aimed at elucidating the fractional composition, volume and toxicity of dust that deposited in snow cover for period accumulation different distances from coal mines a coal-fired power station Kemerovo region (Russia). During filtration process, fractions 10–0.1 µm less than 0.1 were isolated weighed. Light microscopy was used to estimate size particles fraction. We found total composition has no significant trend change research space. The contamination associated mainly with...
Coal worker’s pneumoconiosis (CWP) is an occupationally induced progressive fibrotic lung disease. This irreversible but preventable disease currently affects millions across the world, mainly in countries with developed coal mining industries. Here, we report a pilot study that explores sputum microbiome as potential non-invasive bacterial biomarker of CWP status. Sputum samples were collected from 35 former and active miners diagnosed healthy controls. Sequencing 16S rRNA genes was used to...
Background. The purpose of this study was to investigate the genotoxic risk in anthracosilicosis patients and those with occupational exposure coal dust.
 Materials methods. We studied micronuclei (MN) other cytogenetic lesions blood lymphocytes three groups men comparable age: 74 miners suffering from (AS), 41 healthy miners, 70 control donors.
 Results. A significant increase frequency MN revealed a simultaneous decrease proliferative activity samples sick compared control. level...
The microbiota has a significant, and sometimes decisive, effect on the host's homeostasis. results of recent metagenomic studies confirm importance in maintaining health or its impact development acute, chronic neoplastic diseases. One important aspects exposure is ability many bacterial species to induce mutations modulate mutation process cells host organism. This review summarizes main experimental data revealing various mechanisms genotoxic action microbiota, including direct damage DNA...
Recent studies have shown that the respiratory bacterial microbiome has an impact on development of pulmonary tuberculosis. Changes in composition been associated with pathogenesis Mycobacterium tuberculosis infection, response to therapy, and clinical outcomes disease. To date, not studied patients localized forms Methods. In present study, taxonomic sputum 14 (tuberculomas) healthy donors comparison group was analyzed by sequencing (NGS) V3 – V4 region gene encoding 16S rRNA . Results. The...
Впервые дана оценка влияния качественных и количественных изменений состава бактериального микробиома в мокроте 17 пациентов, страдающих раком легкого, контрольных доноров на показатели цитогенетического гомеостаза соматических клеток. Доноры с высокими значениями (свыше 3,5 %) частот хромосомных аберраций (ХА) имели микробиоме достоверное снижение представителей родов Prevotella, Selenomonas, Veillonella, а также увеличение рода Kocuria по сравнению донорами низким уровнем ХА лимфоцитах. На...
Abstract Objectives : The microbiome of sputum from former and active coal miners diagnosed with worker’s pneumoconiosis (CWP) as compared to healthy controls Methods Next Generation Sequencing bacterial 16S rRNA genes obtained the CWP subjects. Results Differences were detected between microbiomes We noted a significant decrease in Bacteroidetes an increase level Proteobacteria. Conclusions found subjects are enriched species previously reported induce pro-inflammatory responses. profile...