A5101625362- Catalytic C–H Functionalization Methods
- Radical Photochemical Reactions
- Synthesis and Catalytic Reactions
- Oxidative Organic Chemistry Reactions
- Fluorine in Organic Chemistry
- Asymmetric Hydrogenation and Catalysis
- Catalytic Cross-Coupling Reactions
- Sulfur-Based Synthesis Techniques
- Safety and Risk Management
- Coal Properties and Utilization
- Combustion and Detonation Processes
- Inorganic Fluorides and Related Compounds
- Iron and Steelmaking Processes
- Graphite, nuclear technology, radiation studies
- Catalytic Alkyne Reactions
- Cyclopropane Reaction Mechanisms
- Synthesis and Biological Evaluation
- Alkaloids: synthesis and pharmacology
- Carbon dioxide utilization in catalysis
- Synthesis of Indole Derivatives
- Nephrotoxicity and Medicinal Plants
- Electrocatalysts for Energy Conversion
- Geoscience and Mining Technology
- Click Chemistry and Applications
- Galectins and Cancer Biology
Zunyi Medical University
2016-2025
Chengdu University of Technology
2024
Shenyang Ligong University
2024
Inner Mongolia University of Science and Technology
2024
Institute of Engineering Thermophysics
2021-2023
Chinese Academy of Sciences
2011-2023
Hefei University of Technology
2023
University of Chinese Academy of Sciences
2022
China Design Group (China)
2020
Guizhou Magic Pharmaceutical (China)
2019
Given the widespread presence of spirocyclic scaffolds in natural products and pharmacologically relevant synthetic compounds, development efficient methodologies for their construction holds great importance medicinal chemistry pharmaceutical research. In this study, a general photochemical dearomative spirocyclization nonactivated arenes has been established. The key to method lies ability amine-borane radicals activate aryl bromides iodides via halogen-atom transfer, thereby allowing...
A first example of radical hydroboration and hydrosilylation gem-difluoroalkenes using ABIN as the initiator is described. This protocol features good functional group tolerance, operational simplicity, high atom economy, easy scale-up, enabling efficient assembly a wide range α-difluorinated alkylborons alkylsilanes in moderate to excellent yields. The synthetic utility these products demonstrated by further transformation C–B bond C–Si into valuable CF2-containing molecules.
Abstract A photoredox‐catalyzed defluoroborylation of trifluoromethyl alkenes with N ‐heterocyclic carbene boranes is described for the synthesis gem ‐difluoroallylboranes. This protocol exhibits a broad substrate scope and good functional group compatibility, which enables late‐stage functionalization structurally complex compounds. Further transformations products to valuable CF 2 ‐containing molecules are also demonstrated. magnified image
A concise total synthesis of (±)-minfiensine using all conventional methods and starting from commercial materials has been completed. The features a Fischer indole synthesis, Heck alkylation an intermediate ketone enolate, conversion carbonyl into epoxide, transformation the latter allylic alcohol.
A visible-light-initiated trifluoromethylation/remote aliphatic C-H alkynylation of α-alkyl-substituted vinyl azides using acetylenic triflones as both the trifluoromethyl and alkyne donors is described. The reaction occurred under environmentally benign radical initiator-free conditions, affording γ-alkynylated ketone derivatives with a broad scope substituents. Mechanistic studies suggested that initiated via triplet-triplet energy transfer between 4CzIPN catalyst triflone, followed by...
A practical method for the cross-coupling of ethyl 3-bromo-3-alkyl-2,2-difluoropropanoates with coumarins/quinolinones was developed. The IC 50 values 3l against Huh-7 and A549 cells were determined to be 4.6 μM 6.8 μM, respectively.
Described is a mild method that merges organophotoredox catalysis with hydrogen atom transfer to enable C–H alkylation of quinoxalin-2(1H)-ones feedstock aldehydes, amides, alcohols, ethers, or cycloalkanes. This reaction occurred under environmentally benign and external oxidant-free conditions, providing general sustainable access various C3-alkylated quinoxalinone derivatives broad substituent diversity good functional group compatibility.
The remote C(sp<sup>3</sup>)–H functionalization enabled by a radical-mediated 1,5-hydrogen-atom transfer (HAT) process using vinyl azides and 1,4-dihydropyridines as precursors has been described.
A visible-light-triggered ring opening/in situ SO2-capture/alkynylation sequence of cyclopropyl alcohols with alkynyl triflones using 4CzIPN as a triplet energy transfer photocatalyst is herein described. This metal-free protocol provides straightforward and atom-economical approach to alkynyl-substituted γ-keto sulfones broad scope substituents. In this transformation, could be used both radical acceptors SO2 donors. Preliminary experimental mechanistic studies synthetic utility are also...
An efficient and practical approach to 3a‐azidofuroindolines ‐pyrroloindolines involving an iodine‐catalyzed azidation/cyclization cascade of tryptophols tryptamines with NaN 3 was developed. Further transformation the C3‐azidated product provided a key intermediate for total synthesis psychotriasine.
Described is a silver-promoted decarboxylative radical addition/annulation of oxamic acids with<italic>gem</italic>-difluoroalkenes enabling the convenient synthesis various structurally diverse CF<sub>2</sub>-containing 3,4-dihydroquinolin-2-ones that might find applications in medical chemistry.
A radical borylation of vinyl azides with NHC-boranes in the presence t BuSH is described, which enables divergent synthesis α-boryl ketones and borylated triazoles excellent functional group tolerance a broad substrate scope.
The first total synthesis of the antiviral flavonoid houttuynoid A (1) has been achieved from aryl ketone 6 and benzofuran aldehyde 5 in nine linear steps. C6–C3–C6 structure was synthesized by an I2-catalyzed oxa-Michael addition a chalcone intermediate, generated Claisen–Schmidt condensation 6. This work provides method for houttuynoids reference remaining members family.
Abstract An efficient method for the iodine‐catalyzed oxidation of N ‐substituted indoles by using chloramine‐B under mild reaction conditions was explored. This found to be tolerant a variety functional groups and provided corresponding isatins in moderate excellent yields. In addition, application this one‐pot synthesis 3‐hydroxyoxindole ‐methylisatin oxime realized.
Abstract Nanofluid flooding is a novel technology with potential for enhanced oil recovery. In this study, biological nanocomposite system was formed by mixing hexamethyldisilazane-modified hydrophobic nano-SiO 2 biosurfactant produced Bacillus . The stability of the system, its influence on rock wettability, and fluid interfacial tension were investigated experimentally. Numerical simulation methods employed to simulate displacement efficiency optimize injection parameters. Finally,...
A direct oxidative halogenation of terminal alkynes has been realized using chloramine-B as the oxidant and KI or NaBr halogen source. This reaction enables a general practical access to synthetically valuable 1-bromoalkynes 1-iodoalkynes in good excellent yields under mild conditions.
An iodine-catalyzed oxidative annulation of 3-cyanoacetylindoles with benzylamines has been developed. This reaction enables the convenient synthesis a variety 5-(3-indolyl)oxazoles under mild conditions broad functional group compatibility.