A5039669754- Pharmaceutical Practices and Patient Outcomes
- Phytochemicals and Antioxidant Activities
- Alcohol Consumption and Health Effects
- Antibiotic Use and Resistance
- Nitric Oxide and Endothelin Effects
- Free Radicals and Antioxidants
- Antioxidant Activity and Oxidative Stress
- Tea Polyphenols and Effects
- Cardiovascular Health and Disease Prevention
- Gout, Hyperuricemia, Uric Acid
- Pharmaceutical studies and practices
- High Altitude and Hypoxia
- Metabolomics and Mass Spectrometry Studies
- Pharmacovigilance and Adverse Drug Reactions
- Helicobacter pylori-related gastroenterology studies
- Skin Protection and Aging
- Gastroesophageal reflux and treatments
- Fermentation and Sensory Analysis
- Cardiovascular and exercise physiology
- Dermatology and Skin Diseases
- Eicosanoids and Hypertension Pharmacology
- Health Systems, Economic Evaluations, Quality of Life
- Eosinophilic Esophagitis
- Pharmaceutical Economics and Policy
- Neurological Disease Mechanisms and Treatments
University of Split
2014-2024
Kumamoto University
2020
Medizinische Hochschule Hannover
2012
To identify genetic variants underlying biochemical traits--total cholesterol, low-density lipoprotein (LDL) high-density (HDL) triglycerides, uric acid, albumin, and fibrinogen, in a genome-wide association study an isolated population where rare of larger effect may be more easily identified.The included 944 adult inhabitants the island Korcula, as part DNA-based epidemiological 2007. Biochemical measurements were performed single laboratory with stringent internal external quality control...
Determination of the relative contribution uric acid level increases to total measured antioxidative activity could be very useful for testing products and their effect on human health. The aim this report is present a simple spectrophotometric method that combines measurement capacity sample by ferric reducing/antioxidative power (FRAP) assay, with uricase-reaction (specific elimination acid), in order establish correct FRAP values. We values, (uric acid-independent antioxidant capacity,...
Summary The aim of this study was to assess the effects successive deep dives on endothelial function large conduit arteries and plasma pro‐oxidant antioxidant activity. Seven experienced divers performed six in consecutive days using a compressed mixture oxygen, helium nitrogen (trimix) with diving depths ranging from 55 80 m. Before after first, third sixth dive, venous gas emboli formation brachial artery (flow‐mediated dilation, FMD) assessed by ultrasound. In addition, capacity (AOC)...
By using red wine (RW), dealcoholized (DARW), polyphenols-stripped (PSRW), ethanol-water solution (ET), and water (W), the role of polyphenols, ethanol, urate on vascular function was examined in humans (n=9 per beverage) isolated rat aortic rings (n=9). Healthy males randomly consumed each beverage a cross-over design. Plasma catechin, concentrations were measured before 30, 60 120 minutes after intake. Endothelial assessed consumption by normalized flow-mediated dilation (FMD). RW DARW...
In contrast to the well-described various biological effects of grape wines, potential commonly consumed blackberry wine have not been studied. We examined in vitro antioxidant and vasodilatory four wines compared them with two red white wines. Although some had lower total phenolic content relative their capacity was stronger, which may be related a higher non-flavonoid compounds (most notably gallic acid) maximal vasodilation induced by generally similar that were less potent vasodilators....
Abstract: While the antimicrobial effectiveness of wine is well documented, relative contributions components to its activity controversial. To separate role phenolics, ethanol, and pH from other constituents, effects intact were compared that phenols‐stripped wine, dealcoholized low applied separately in combination, against 2 common foodborne pathogens, Salmonella enterica serovar Enteritidis Escherichia coli . All samples biochemically characterized with respect their total phenolics...
Antimicrobial resistance is recognised as one of the top threats healthcare bound to face in future. There have been various attempts preserve efficacy existing antimicrobials, develop new and efficient manage infections with multi-drug resistant strains, improve patient outcomes, resulting a growing mass routinely available data, including electronic health records microbiological information that can be employed individualised antimicrobial stewardship. Machine learning methods developed...
We have recently shown that a single air dive leads to acute arterial vasodilation and impairment of endothelium-dependent vasodilatation in humans. Additionally we found predive antioxidants at the upper recommended daily allowance partially prevented some negative effects dive. In this study prospectively evaluated effect long-term lower RDA dose on endothelial function.Eight professional male divers performed an open sea 30 msw. Brachial artery flow-mediated dilation (FMD) was assessed...
Summary The aim of this study was to measure plasma nitrite, the biochemical marker endothelial nitric oxide ( • NO ) synthesis, before and after hyperoxia, in order test hypothesis that hyperoxia‐induced vasoconstriction is a consequence reduced bioavailability caused by elevated oxidative stress. Ten healthy men breathed 100% normobaric O 2 for 30 min between 15th 45th 1‐h protocol. Plasma nitrite malondialdehyde MDA ), arterial stiffness (indicated augmentation index, AI x) oxygen P tc...
Aims: The aim of this study was to evaluate pharmacists' and physicians' attitudes knowledge about antimicrobial treatment resistance based on the results identify possible gaps suggest opportunities for collaboration between two professions. Methods: physician's questionnaire consisted 47 items 50 items. Participants were asked situations in which they more likely prescribe/dispense an without a firm indication, greatest contributors (AMR) among health care workers, rate statements related...
Purpose: Future physicians and pharmacists have to be educated prepared rationally manage the use of antimicrobials. The aim this study was evaluate attitudes knowledge regarding antimicrobials antimicrobial resistance medical pharmacy students. Methods: We conducted a survey-based cross-sectional at University Split School Medicine (USSM). survey consisted 50 items. A total 161 students participated in across 3 programs as follows: (N = 78), Medical Studies English (MSE; N 37), Pharmacy...