A5070430303- Cardiac Imaging and Diagnostics
- Nutrition, Genetics, and Disease
- Atrial Fibrillation Management and Outcomes
- Infective Endocarditis Diagnosis and Management
- Venous Thromboembolism Diagnosis and Management
- Acute Myocardial Infarction Research
- Cardiac Valve Diseases and Treatments
- COVID-19 Clinical Research Studies
- Cardiac tumors and thrombi
- Cardiovascular Function and Risk Factors
- Inflammatory Biomarkers in Disease Prognosis
- Congenital Heart Disease Studies
- Coronary Artery Anomalies
- Peripheral Artery Disease Management
- Genetic Associations and Epidemiology
- Cardiac Arrhythmias and Treatments
- Cardiovascular Effects of Exercise
- Health and Well-being Studies
- Genetic and phenotypic traits in livestock
- Diagnosis and Treatment of Venous Diseases
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiac pacing and defibrillation studies
- Cardiovascular Disease and Adiposity
- Sepsis Diagnosis and Treatment
- Glycosylation and Glycoproteins Research
University Hospital Dubrava
2015-2025
University North
2022-2024
Catholic University of Croatia
2022
University of Split
2009-2018
University of Edinburgh
2013
Bayer (Germany)
1987
Abstract Fibrinogen is a major plasma glycoprotein involved in blood coagulation and inflammatory responses. Alterations its glycosylation have been implicated various pathological conditions, yet site-specific N-glycosylation profile remains largely unexplored clinical context. Here, we present high-throughput LC-MS workflow for analysis of fibrinogen using cost-effective ethanol precipitation enrichment method. The method demonstrated good intra- inter-plate repeatability (CV: 5% 12%,...
Fibrinogen is a major plasma glycoprotein involved in blood coagulation and inflammatory responses. Alterations its glycosylation have been implicated various pathological conditions; yet, site-specific N-glycosylation profile remains largely unexplored clinical context. Here, we present high-throughput LC-MS workflow for analysis of fibrinogen using cost-effective ethanol precipitation enrichment method. The method demonstrated good intra- interplate repeatability (CV: 5% 12%, respectively)...
To identify genetic variants underlying biochemical traits--total cholesterol, low-density lipoprotein (LDL) high-density (HDL) triglycerides, uric acid, albumin, and fibrinogen, in a genome-wide association study an isolated population where rare of larger effect may be more easily identified.The included 944 adult inhabitants the island Korcula, as part DNA-based epidemiological 2007. Biochemical measurements were performed single laboratory with stringent internal external quality control...
Atrial fibrillation is a disease with complex pathophysiology, whose occurrence and persistence are caused not only by aberrant electrical signaling in the heart, but development of susceptible heart substrate. These changes, such as accumulation adipose tissue interstitial fibrosis, characterized presence inflammation. N-glycans have shown great promise biomarkers different diseases, specifically those involving inflammatory changes. To assess changes N-glycosylation plasma proteins IgG...
Background and aim: There are few prospective data on the prognostic value of normal admission low-density lipoprotein cholesterol (LDL-C) in statin-naïve patients with acute coronary syndromes (ACS) who treated a preemptive invasive strategy. We aimed to analyze proportion LDL-C at for ACS our practice, their characteristics clinical outcomes comparison high LDL-C. Patients methods: Two institutions’ registries confirmed from Jan 2017 2023 were used identify 1579 no history prior artery...
AimTo evaluate the quality of antenatal care (ANC) in Hebei Province and compare it between public private sector within sector.MethodsWe conducted a Maternal, Newborn Child Health Household Survey 2010 using two-stage sampling procedure included 1079 mothers. The ANC was assessed on basis number visits, time first visit, 16 different procedures, owning maternal health booklet, type service provider.ResultsAlmost all women (98%) received services at least once, 80% four times, 54% five...
To develop affordable, appropriate, and nutritious recipes based on local food resources dietary practices that have the potential to improve infant feeding practices.We carried out a mixed methods study following World Health Organization's evaluation guidelines promotion of child feeding. We recruited caregivers with children aged 6-23 months in Wuyi County, Hebei Province, China. The included 24-hour recall survey, market development key list, combinations, recipes. Mothers tested...
AimTo investigate possible interactions between genetic variants in glucose transporter type 9 (SLC2A9) gene and dietary habits serum uric acid regulation.MethodsParticipants for this study were recruited from two isolated Croatian island communities of Vis (n = 918) Korčula 898). Three single nucleotide polymorphisms (SNP) the SLC2A9 (rs1014290, rs6449213, rs737267) correlated with acid.ResultsA significant decrease levels was recorded increasing consumption milk, sour cream, duck turkey,...
AimTo investigate clinical and prognostic associations of red cell distribution width (RDW) in hospitalized coronavirus disease 2019 (COVID-19) patients.MethodsWe retrospectively analyzed the records 3941 consecutive COVID-19 patients admitted to a tertiary-level institution from March 2020 2021 who had available RDW on admission.ResultsThe median age was 74 years. The Charlson comorbidity index (CCI) 4. majority (84.1%) admission presented with severe or critical COVID-19. Patients higher...
Isolation is a known force in evolutionary biology and one of the main factors speciation. One consequences severe isolation reduced mate choice, which results occurrence inbreeding as result isolation. We investigated effects individual genome-wide heterozygosity measured multilocus (MLH) on biochemical markers hemostasis inflammation 1,041 individuals from island Vis, Croatia, where prevalent wide range variation expected. Assessment was based scans using 800 microsatellite (STR) 317,503...
AimTo assess the frequency of 32 base pair deletion in CCR5 (CCR5Δ32), which has been shown to confer resistance HIV infection a homozygous form, 10 isolated island communities Dalmatia, Croatia, with different histories exposure epidemics during and since medieval period.MethodsIn 2002, DNA analysis 100 randomly selected individuals from each 5 Croatian islands (Susak, Rab, Vis, Lastovo, Mljet) showed high levels 3-generational endogamy, indicating limited gene flow. Five were decimated by...
Abstract An epidemiological transition in the prevalence of peripheral artery disease (PAD) is taking place especially low- and middle-income countries (LMICs) where an ageing population adoption western lifestyles are associated with increase PAD. We discuss limited evidence which suggests that infection, potentially mediated by inflammation, may be a risk factor for PAD, show means ecological analysis country-level major endemic infections HIV, tuberculosis malaria While further research...