A5061428191- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Cellular transport and secretion
- Phagocytosis and Immune Regulation
- Crystallography and molecular interactions
- Cell Adhesion Molecules Research
- Cell death mechanisms and regulation
- Photochromic and Fluorescence Chemistry
- Coordination Chemistry and Organometallics
- Lipid Membrane Structure and Behavior
- Erythrocyte Function and Pathophysiology
- Cellular Mechanics and Interactions
- Organometallic Complex Synthesis and Catalysis
- Organoboron and organosilicon chemistry
- Calcium signaling and nucleotide metabolism
The Ohio State University
2021-2024
Macalester College
2018
Abstract The transmembrane death receptor Fas transduces apoptotic signals upon binding its ligand, FasL. Although is highly expressed in cancer cells, insufficient cell surface expression desensitizes cells to Fas-induced apoptosis. Here, we show that the increase microaggregate formation on plasma membrane response inhibition of endocytosis sensitizes We used a clinically accessible Rho-kinase inhibitor, fasudil, reduces dynamics by increasing tension. In combination with exogenous soluble...
New tris(phosphinomethyl)phenylborate ligands were synthesized to examine tuning of PhBP<sup>Ph</sup><sub>3</sub> donation <italic>via</italic> inductive modulation the borate charge. Cyclic voltammetry suggests that rational this type occurs in complexes zerovalent metals.
Integrin-based adhesion complexes are crucial in various cellular processes, including proliferation, differentiation, and motility. While the dynamics of canonical focal (FAs) have been extensively studied, regulation physiological implications recently identified clathrin-containing (CCACs) still not well understood. In this study, we investigated spatiotemporal mechanoregulations FAs CCACs a breast cancer model. Employing single-molecule force spectroscopy coupled with live-cell...