A5032512562- HIV/AIDS Research and Interventions
- LGBTQ Health, Identity, and Policy
- Adolescent Sexual and Reproductive Health
- HIV, Drug Use, Sexual Risk
- Sexuality, Behavior, and Technology
- Sex work and related issues
- Mobile Health and mHealth Applications
- Immune Response and Inflammation
- Reproductive Health and Technologies
- Adolescent and Pediatric Healthcare
- Respiratory viral infections research
- Sexual Differentiation and Disorders
- HIV Research and Treatment
- Gender Roles and Identity Studies
- Neonatal Respiratory Health Research
- Homelessness and Social Issues
- Chemokine receptors and signaling
- interferon and immune responses
- Infant Nutrition and Health
- Social Robot Interaction and HRI
- Sex and Gender in Healthcare
- HIV/AIDS drug development and treatment
- HIV/AIDS Impact and Responses
- Intimate Partner and Family Violence
- Cell Adhesion Molecules Research
Northwestern University
2016-2025
Lurie Children's Hospital
2016-2025
The University of Texas Medical Branch at Galveston
2014-2024
Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione
2023
University of Pisa
2015-2021
Piaggio (Italy)
2015-2021
University of Chicago
2021
Florida College
2021
Columbia University Irving Medical Center
2021
Boston Children's Hospital
1998-2020
ABSTRACT The Standards of Care (SOC) for the Health Transsexual, Transgender, and Gender Nonconforming People is a publication World Professional Association Transgender (WPATH). overall goal SOC to provide clinical guidance health professionals assist transsexual, transgender, gender nonconforming people with safe effective pathways achieving lasting personal comfort their gendered selves, in order maximize health, psychological well-being, self-fulfillment. This assistance may include...
Objective. This study is one of the first to examine association between sexual orientation and health risk behaviors among a representative, school-based sample adolescents. Design. was conducted on an anonymous, representative 4159 9th- 12th-grade students in public high schools from Massachusetts' expanded Centers for Disease Control Prevention 1995 Youth Risk Behavior Survey. Sexual determined by following question: “Which best describes you?” A total 104 self-identified as gay, lesbian,...
We examined associations of race/ethnicity, gender, and sexual orientation with mental disorders among lesbian, gay, bisexual, transgender (LGBT) youths.We assessed by administering a structured diagnostic interview to community sample 246 LGBT youths aged 16 20 years. Participants also completed the Brief Symptom Inventory 18 (BSI 18).One third participants met criteria for any disorder, 17% conduct 15% major depression, 9% posttraumatic stress disorder. Anorexia bulimia were rare. Lifetime...
<h3>Objective</h3> To examine whether sexual orientation is an independent risk factor for reported suicide attempts. <h3>Design</h3> Data were from the Massachusetts 1995 Centers Disease Control and Prevention Youth Risk Behavior Survey, which included a question on orientation. Ten drug use, 5 behavior, violence/victimization variables chosen priori assessed as possible mediating variables. Hierarchical logistic regression models determined predictors of <h3>Setting</h3> Public high...
Background: Young men who have sex with (YMSM) experience disparities in HIV rates and potentially mental health, substance abuse, exposure to violence. Purpose: We assessed the extent which these psychosocial health problems had an additive effect on increasing risk among YMSM. Methods: An urban sample of 310 ethnically diverse YMSM reported problems, sexual behaviors, status. A count was calculated test relationship risk. Results: The prevalence varied from 23% for regular binge drinking...
We assessed whether multiple psychosocial factors are additive in their relationship to sexual risk behavior and self-reported HIV status (i.e., can be characterized as a syndemic) among young transgender women the of indicators social marginalization factors.Participants (n = 151) were aged 15 24 years lived Chicago or Los Angeles. collected data on (low self-esteem, polysubstance use, victimization related identity, intimate partner violence) (history commercial sex work, homelessness,...
Abstract The chemokine CXCL1/MGSA plays a pivotal role in the host immune response by recruiting and activating neutrophils for microbial killing at tissue site. CXCL1 exists reversibly as monomers dimers, mediates its function binding glycosaminoglycans (GAG) CXCR2 receptor. We recently showed that both dimers are potent agonists, dimer is high-affinity GAG ligand, lysine arginine residues located two non-overlapping domains mediate interactions, there extensive overlap between...
The purpose of this clinical report is to provide pediatricians updated research on evidence-based sexual and reproductive health education conducted since the original subject was published by American Academy Pediatrics in 2001. Sexuality defined as teaching about human sexuality, including intimate relationships, anatomy, reproduction, sexually transmitted infections, activity, orientation, gender identity, abstinence, contraception, rights responsibilities. Developmentally appropriate...
In the summer of 2013, Dr. Jack Drescher published an editorial opinion about gender-nonconforming children in New York Times which he stated: ''Currently experts can't tell apart kids who outgrow gender dysphoria (desisters) from those do not (persisters), and how to treat them is controversial'' [Drescher, p. 1]. As members a four-site child clinic group, we concur with regarding controversy, but take issue his assessment their inability differentially assess ''persisters'' ''desisters''...
Research suggests that lesbian, gay, and bisexual (LGB) youths are at increased risk for both victimization internalizing mental health problems, but limited research has studied their association or factors increase resilience. The sample in this study included 425 LGBs between the ages of 16 24 years. majority had disclosed sexual orientation to family friends (98%), 97% someone lives who was accepting orientation. Racial/ethnic minority female participants general reported lower levels...
Limited prospective outcome data exist regarding transgender and nonbinary youth receiving gender-affirming hormones (GAH; testosterone or estradiol).We characterized the longitudinal course of psychosocial functioning during 2 years after GAH initiation in a cohort United States. Participants were enrolled four-site prospective, observational study physical outcomes. completed Transgender Congruence Scale, Beck Depression Inventory-II, Revised Children's Manifest Anxiety Scale (Second...
This study examined the HIV risk behaviors and life experiences of 151 transgender female youth, ages 15–24, in Los Angeles Chicago. Descriptive analyses logistic regression modeling were used to identify factors associated with ever having engaged sex work. Sixty-seven percent participants had work 19% self-reported being positive. Many significantly for this sample population. A final multivariate model found that lower education status, homelessness, use street drugs, perceived social...
The transcription factor nuclear (NF)-kappaB controls the expression of numerous respiratory syncytial virus (RSV)-inducible inflammatory and immunomodulatory genes. Using a BALB/c mouse model, present article shows that RSV potently specifically activates NF-kappaB in vivo, process involves translocation subunits RelA, p50, c-Rel lung. By depletion alveolar macrophages (AMs) mice use C3H/HeJ lacking functional Toll-like receptor (TLR)-4 signaling pathway, we demonstrate existence distinct...
The most common cause of epidemic pediatric respiratory disease, syncytial virus (RSV), stimulates interleukin-8 (IL-8) synthesis upon infecting airway epithelium, an event necessary for the development mucosal inflammation. We investigated mechanism enhanced IL-8 production in human A549 type II pulmonary epithelial cells. Infection with sucrose-purified RSV (pRSV) produced a time-dependent increase transcriptional initiation rate gene. Transient transfection promoter mutated binding site...
For youth living with human immunodeficiency virus (HIV)/acquired syndrome (AIDS), nonadherence to antiretroviral therapy (ART) can lead poor health outcomes and significantly decreased life expectancy.To evaluate the feasability, acceptability, preliminary efficacy of short message service (SMS) or text reminders improve adherence ART for HIV/AIDS.We conducted this prospective pilot study using a pre-post design from 2009 2010 at community-based center providing clinical services HIV/AIDS....
We examined the prevalence of Internet use for meeting sexual partners (Internet partners) and HIV risk behaviors associated with this among young men who have sex (aged 16-24 years).
Young men who have sex with (MSM) represent an increasing number of new HIV infections in many communities. Many individuals still hold beliefs that may lead to discrimination against HIV-positive individuals. stigma is associated negative health and psychosocial outcomes greater challenges for this marginalized population. This study describes experienced by young MSM, explores its relationship measures, tests the hypothesis scores will be higher those diagnosed less than 1 year ago versus...
Background: This study examined the feasibility of a combination prevention intervention for young men who have sex with (YMSM), an anticipated target population HIV preexposure prophylaxis (PrEP). Methods: Project PrEPare, pilot using randomized 3-arm design, compared efficacious behavioral (Many Men, Many Voices—3 MV) alone, 3 MV combined PrEP (tenofovir/emtricitabine), and placebo. Eligible participants were 18- to 22-year-old HIV-uninfected reported unprotected anal intercourse in past...