A5074011844- Computational Drug Discovery Methods
- Synthesis and biological activity
- Pharmacogenetics and Drug Metabolism
- Steroid Chemistry and Biochemistry
- Natural Antidiabetic Agents Studies
- Fish Biology and Ecology Studies
- Pharmacological Effects and Toxicity Studies
- Electrolyte and hormonal disorders
- Metal complexes synthesis and properties
- Ion Transport and Channel Regulation
- Pharmacological Effects of Natural Compounds
- Microbial Natural Products and Biosynthesis
- Glycosylation and Glycoproteins Research
- Monoclonal and Polyclonal Antibodies Research
- Aquaculture disease management and microbiota
- Hormonal and reproductive studies
- Mass Spectrometry Techniques and Applications
- Research on Leishmaniasis Studies
- Synthesis and Characterization of Heterocyclic Compounds
- Analytical Chemistry and Chromatography
- Phytochemicals and Antioxidant Activities
- Biological Research and Disease Studies
Dow University of Health Sciences
2019-2022
University of Karachi
2012-2021
International Center for Chemical and Biological Sciences
2012-2018
This study reports synthesis of flavone hydrazide Schiff base derivatives with diverse functionalities for the cure diabetic mellitus and their a-glucosidase inhibitor in silico studies. In this regard, Flavone 1–20 has synthesized characterized by various spectroscopic techniques. These compounds showed significant potential towards enzyme inhibition activity found to be many fold better active than standard Acarbose (IC50 = 39.45 ± 0.11 µM). The IC50values ranges 1.02–38.1 µM. Among these,...
Abstract. The study was undertaken from September 2018 to April 2019 determine the prevalence of cutaneous leishmaniasis in human beings living six districts Karachi. Suspected persons were screened for disease and positive cases identified on basis skin lesions blood samples. Samples observed by mounting their smear. A total 207 subjects different ages sex groups investigated, however, only 192 (92%) suspected found have 64% male which significantly high (p<0.05), than female 36%. lesion...
Identification of hotspot drug-receptor interactions through in-silico prediction methods (Pharmacophore mapping, virtual screening, 3DQSAR, etc), is considered as a key approach in drug designing and development process. In the current design study, advanced based computational techniques were used for identification lead-like molecules against targeted receptor β-glucuronidase. The binding pattern potent inhibitor ligand-receptor X-ray co-crystallize complex was to identify extract...
New potential biological targets prediction through inverse molecular docking technique is another smart strategy to forecast the possibility of compounds being biologically active against various target receptors.In this case designed study, we screened our recently obtained novel acetylenic steroidal biotransformed products [(1) 8-β-methyl-14-α-hydroxyΔ4tibolone (2) 9-α-HydroxyΔ4 tibolone (3) 8-β-methyl-11-β-hydroxyΔ4tibolone (4) 6-β-hydroxyΔ4tibolone, (5) 6-β-9-α-dihydroxyΔ4tibolone (6)...
Intestinal β-glucuronidase enzyme has a significant importance in colorectal carcinogenesis. Specific inhibition of the helps prevent immune reactivation glucuronide- carcinogens, thus protecting intestine from ROS (Reactive Oxidative Species) mediatedcarcinogenesis.Advancement In-silico based techniques provided broad range studies to carry out drug design and development process smoothly using SwissADME BOILED-Egg tools.In our designed case study, we used predictive computational tools...
Objective: In order to predict the pharmacokinetic properties, and new potential biological targets, targets prediction, absorption, distribution, metabolism excretion (ADME) profiling of newly synthesized Entgegen / Zusammen (E Z isomers) Methyl 2-phenyl-2-(2-phenylhydrazono) acetate derivatives were carried out. Methods: The prediction membrane permeability, bioavailability radar properties out by using Swiss Targets Prediction ADME tools, respectively. Results: All eight screened...
Type 2 diabetes mellitus (T2DM) known as non-insulin dependent mellitus, is a chronic metabolic disorder caused by insulin deficiency or resistance. The incidence of T2DM increasing day day. According to data from World Health Organization (WHO), the number diabetic patients expected rise up 642 million 2040.This alarming situation needs proper treatment control diabetes. Physicians mostly prescribe based medications, but in this new medical era, α-glucosidase inhibitors (AGIs) drug therapy...