A5062274212- Renal Transplantation Outcomes and Treatments
- Cancer Genomics and Diagnostics
- Organ Transplantation Techniques and Outcomes
- Transplantation: Methods and Outcomes
- Renal Diseases and Glomerulopathies
- Organ Donation and Transplantation
- Complement system in diseases
- Blood groups and transfusion
- X-ray Spectroscopy and Fluorescence Analysis
- Immunotherapy and Immune Responses
- Cytomegalovirus and herpesvirus research
- Virus-based gene therapy research
- Immune Cell Function and Interaction
- Lanthanide and Transition Metal Complexes
- Pancreatic and Hepatic Oncology Research
- RNA Interference and Gene Delivery
- Hepatocellular Carcinoma Treatment and Prognosis
- Molecular Biology Techniques and Applications
- CRISPR and Genetic Engineering
- Hematopoietic Stem Cell Transplantation
- Inorganic Fluorides and Related Compounds
PAX Scientific (United States)
2021-2024
Hospital Universitário Cajuru
2003-2024
Pontifícia Universidade Católica do Paraná
2003-2018
Abstract Background We describe our single-center experience in performing donor-derived cell-free DNA (dd-cfDNA) testing for a clinical indication pediatric kidney transplant recipients. Methods Dd-cfDNA was done increase creatinine, appearance of de novo anti-HLA antibodies ( dn HLAab) and indication. compared characteristics patients with dd-cfDNA > 1 those ≤ also no biopsy proven rejection (BPAR) or HLAab BPAR, BPAR. Results Chart review performed 106 mean age 11.0 ± 5.5 years. When...
The identification of low-level antibodies by single-antigen bead methodology has brought advancements to risk evaluation kidney transplant recipients. However, the use mean fluorescence intensity (MFI) quantify and guide therapy is not enough. Notably, immunoglobulin G (IgG) subclass switching hypothesized follow a programmed sequence after an emergency signal from germinal center. In transplantation this process clear yet. present study, we sequentially evaluate anti-HLA donor specific...
The diagnosis of graft-versus-host-disease (GVHD) after solid organ transplantation is made difficult by its variable clinical presentation and lack sensitive specific biomarkers to evaluate the immune state transplant recipients. Emerging noninvasive diagnostic techniques like quantification donor-derived cell-free DNA (dd-cfDNA) for surveillance may improve current standard-of-care. Herein, we report use this methodology in a patient with GVHD corresponding levels dd-cfDNA without any...
Background: The transplant of kidneys with high KDPI, and the incidence duration delayed graft function (DGF) are risk factors associated incomplete recovery kidney (IRF). In both situations, biopsies essential to exclude diagnosis acute rejection (AR). Purpose: This study evaluates clinical utility monitoring donor-derived cell-free DNA (dd-cfDNA), a biomarker injury, in recipients Kidney Donor Profile Index (KDPI) transplants during period recovery. Methods: is single center, prospective,...
Background: Donor-derived cell- free DNA (dd-cfDNA) is a useful plasma biomarker to assess allograft injury and rejection in kidney transplant recipients (KTRs). Serial monitoring of dd-cfDNA recommended monitor determine adequacy immunosuppression. Although, serum creatinine increase marker for dysfunction, it limited by variations hydration status, increased muscle mass, growth children. Herein, we describe single-center experience on 1) the indications performing fraction pediatric KTRs...