A5005899987- Renal Transplantation Outcomes and Treatments
- SARS-CoV-2 and COVID-19 Research
- Organ Transplantation Techniques and Outcomes
- Hepatitis B Virus Studies
- Renal and Vascular Pathologies
- Organ Donation and Transplantation
- Hepatitis C virus research
- Complement system in diseases
- Prenatal Screening and Diagnostics
- Pregnancy and Medication Impact
- Cancer Genomics and Diagnostics
- Heparin-Induced Thrombocytopenia and Thrombosis
PAX Scientific (United States)
2020-2023
The diagnosis of graft-versus-host-disease (GVHD) after solid organ transplantation is made difficult by its variable clinical presentation and lack sensitive specific biomarkers to evaluate the immune state transplant recipients. Emerging noninvasive diagnostic techniques like quantification donor-derived cell-free DNA (dd-cfDNA) for surveillance may improve current standard-of-care. Herein, we report use this methodology in a patient with GVHD corresponding levels dd-cfDNA without any...
Understanding immunogenicity and alloimmune risk following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination in kidney transplant recipients is imperative to understanding the correlates of protection inform clinical guidelines.We studied 50 SARS-CoV-2 quantified their anti-spike protein antibody, donor-derived cell-free DNA (dd-cfDNA), gene expression profiling (GEP), alloantibody formation.Participants were stratified using nucleocapsid testing as either...
Introduction: Following kidney transplantation, women of childbearing age often experience rapid restoration fertility as the feedback mechanisms hypothalamic-pituitary-gonadal axis normalize. Although rates rejection during pregnancy are comparable to non-pregnant transplant population, subtle indications allograft injury such increases in serum creatinine or proteinuria can be masked by related changes. Here, we describe a novel approach surveillance using quantification fetal and...
<sec> <title>BACKGROUND</title> Patients with end-stage kidney disease require complex and expensive medical management. Kidney transplantation remains the treatment of choice for is considered superior to all other modalities renal replacement therapy or dialysis. However, access transplant limited by critical supply demand, making it extremely important ensure longevity transplanted kidneys. This prevented through lifelong immunosuppression, caution not overly suppress immune system,...
Introduction: Evolving data suggests that booster vaccine doses enhance the immunogenicity of SARS-CoV-2 vaccination in solid organ transplant (SOT) recipients with higher IgG responses, neutralizing antibodies titers, and greater SARS-CoV-2–specific T-cell counts. However, antibody responses are attenuated by immunosuppression regimens a significant proportion patients continue to be at high risk for infection despite vaccination. Currently, there is no recommended framework monitoring...
Introduction: Preliminary studies suggest that kidney transplant recipients (KTRs) show diminished humoral responses to SARS-CoV-2 vaccination. Although reports of allograft rejection around the time vaccination have been rare, there is no recommended framework for monitoring potential vaccine-related injury. Here, we describe an approach longitudinal assessment immunogenicity and safety SARS-COV-2 in KTRs. Methods: KTRs eligible were identified through medical records, beginning March 12,...
Introduction: Correlates of protection for SARS-CoV-2 vaccines are not yet well-established in kidney transplant recipients (KTRs). Studies have highlighted the importance neutralizing antibodies (Abs), however data suggests T cell responses may play a secondary role preventing reinfection. We performed longitudinal assessment immunogenicity and B KTRs following vaccination. Methods: eligible vaccination were screened through medical records from March 12, 2021. Baseline weekly blood samples...
Background Patients with end-stage kidney disease require complex and expensive medical management. Kidney transplantation remains the treatment of choice for is considered superior to all other modalities renal replacement therapy or dialysis. However, access transplant limited by critical supply demand, making it extremely important ensure longevity transplanted kidneys. This prevented through lifelong immunosuppression, caution not overly suppress immune system, resulting in toxicity...