A5081908264- Renal Transplantation Outcomes and Treatments
- Organ Transplantation Techniques and Outcomes
- Organ Donation and Transplantation
- Renal Diseases and Glomerulopathies
- Transplantation: Methods and Outcomes
- Hepatitis C virus research
- Liver Disease and Transplantation
- Renal and Vascular Pathologies
- Complement system in diseases
- Hepatitis B Virus Studies
- Dialysis and Renal Disease Management
- Polyomavirus and related diseases
- Diabetes Treatment and Management
- Pharmaceutical industry and healthcare
- Frailty in Older Adults
- Nerve injury and regeneration
- Xenotransplantation and immune response
- SARS-CoV-2 and COVID-19 Research
- Pregnancy and Medication Impact
- Pharmacological Effects and Toxicity Studies
- Systemic Lupus Erythematosus Research
- Nutrition and Health in Aging
- Organ and Tissue Transplantation Research
- Axon Guidance and Neuronal Signaling
- Palliative Care and End-of-Life Issues
New York University
2017-2025
NYU Langone Health
2017-2025
Miami Transplant Institute
2017-2025
Johns Hopkins Medicine
2008-2023
Johns Hopkins University
2009-2023
Saint Louis University
2023
Jefferson College
2023
Aarhus University
2023
Thomas Jefferson University
2023
Jefferson College of Health Sciences
2023
More than 20,000 candidates for kidney transplantation in the United States are sensitized to HLA and may have a prolonged wait transplant, with reduced rate an increased of death. One solution is perform live-donor renal after depletion donor-specific anti-HLA antibodies. Whether such antibody results survival benefit as compared waiting HLA-compatible unknown.We used protocol that included plasmapheresis administration low-dose intravenous immune globulin desensitize 211 HLA-sensitized...
A report from a high-volume single center indicated survival benefit of receiving kidney transplant an HLA-incompatible live donor as compared with remaining on the waiting list, whether or not deceased was received. The generalizability that finding is unclear.
Xenografts from genetically modified pigs have become one of the most promising solutions to dearth human organs available for transplantation. The challenge in this model has been hyperacute rejection. To avoid this, bred with a knockout alpha-1,3-galactosyltransferase gene and subcapsular autologous thymic tissue.We transplanted kidneys these into two brain-dead recipients whose circulatory respiratory activity was maintained on ventilators duration study. We performed serial biopsies...
Key Points Posoleucel was generally safe, well tolerated, and associated with a greater reduction of BK viremia compared placebo. occurred coincident an increase in the circulating frequency virus–specific T cells posoleucel recipients. The presence persistence confirmed by T-cell receptor variable β sequencing. Background Kidney transplant recipients virus infection are at risk developing virus–associated nephropathy, allograft rejection, subsequent graft loss. There no approved treatments...
Cyclic AMP response element-binding protein (CREB) is a widely expressed transcription factor whose role in neuronal protection now well established. Here we report that CREB present the mitochondrial matrix of neurons and it binds directly to cyclic elements (CREs) found within genome. Disruption activity mitochondria decreases expression subset genes, including ND5 subunit complex I, down-regulates I-dependent respiration, increases susceptibility 3-nitropropionic acid, toxin induces...
We report that developmental competition between sympathetic neurons for survival is critically dependent on a sensitization process initiated by target innervation and mediated series of feedback loops. Target-derived nerve growth factor (NGF) promoted expression its own receptor TrkA in mouse rat prolonged TrkA-mediated signals. NGF also controlled brain-derived neurotrophic neurotrophin-4, which, through the p75, can kill neighboring with low retrograde NGF-TrkA signaling whereas high are...
To test whether frailty, a novel measure of physiologic reserve, is associated with longer kidney transplant (KT) length stay (LOS), and modifies the association between LOS mortality.Better understanding necessary for informed consent discharge planning. Mortality resulting from has important regulatory implications hospital programs. Which recipients are at risk prolonged its effect on mortality unclear. Frailty preoperative predictor poor KT outcomes including delayed graft function,...
Renal transplantation in patients with antiphospholipid antibodies has historically proven challenging due to increased risk for thrombosis and allograft failure. This is especially true antibody syndrome (APS) its rare subtype, the catastrophic (CAPS). Since a critical mechanism of APS/CAPS one mediated by complement activation, we hypothesized that preemptive treatment terminal inhibitor, eculizumab, would reduce extent vascular injury thrombosis, enabling renal whom it otherwise be...
Frailty increases early hospital readmission and mortality risk among kidney transplantation (KT) recipients. Although frailty represents a high-risk state for this population, the correlates of frailty, patterns 5 components, associated with these are unclear.Six hundred sixty-three KT recipients were enrolled in cohort study (12/2008-8/2015). Frailty, activities daily living (ADL)/instrumental ADL (IADL) disability, Centers Epidemiologic Studies Depression Scale depression, education,...
Background Incompatible live donor kidney transplantation is associated with an increased rate of antibody-mediated rejection (AMR) and subsequent transplant glomerulopathy. For patients severe, oliguric AMR, graft loss inevitable without timely intervention. Methods We reviewed our experience rescuing allografts this severe AMR phenotype by using splenectomy alone (n=14), eculizumab (n=5), or plus in addition to plasmapheresis. Results The study population was 267 consecutive donor-specific...
Objectives: The presence of a donor-specific positive crossmatch has been considered to be contraindication kidney transplantation because the risk hyperacute rejection. Desensitization is process removing hazardous preformed antibody (DSA) in order safely proceed with transplant. Traditionally, this involves plasmapheresis and intravenous immune globulin treatments that occur over days weeks, feasible when there living donor date transplant known, allowing time for pre-emptive treatments....
The Kidney Allocation System (KAS), a major change to deceased donor kidney allocation, was implemented in December 2014. Goals of KAS included directing the highest-quality organs younger/healthier recipients and increasing access transplantation (DDKT) for highly sensitized patients racial/ethnic minorities. Using national registry data, we compared distribution, DDKT rates waitlist registrants, recipient characteristics between January 1, 2013, 3, 2014 (pre-KAS) with those 4, 2014, August...
Background. Highly HLA sensitized patients have limited access to life-saving kidney transplantation because of a paucity immunologically suitable donors. Imlifidase is cysteine protease that cleaves IgG leading rapid decrease in antibody level and inhibition IgG-mediated injury. This study investigates the efficacy safety imlifidase converting positive crossmatch test negative, allowing highly be transplanted with living or deceased donor kidney. Methods. open-label, single-arm, phase 2...
Imlifidase is a cysteine proteinase which specifically cleaves IgG, inhibiting Fc-mediated effector function within hours of administration. converts positive crossmatch to potential donor (T cell, B or both), negative, enabling transplantation occur between previously HLA incompatible donor-recipient pairs. To date, 39 patients received imlifidase prior kidney transplant in four single-arm, open-label, phase 2 studies. At 3 years, for who were AMR+ compared AMR-, death-censored allograft...
The recent national focus on patient safety has led to a re-examination of the risks and benefits nighttime surgery. In liver transplantation, hypothetical operation must be weighed against either well-established prolonging cold ischemia or potential strategies manipulate operative start times. A retrospective review was conducted 578 transplants performed at single institution between 1995 2008 determine whether incidence postoperative complications correlated with We hypothesized that no...
The updated Banff classification allows for the diagnosis of antibody-mediated rejection (AMR) in absence peritubular capillary C4d staining. Our objective was to quantify allograft loss risk patients with consistently C4d-negative AMR (n = 51) compared C4d-positive 156) and matched control subjects without AMR. All first-year posttransplant biopsy results from January 2004 through June 2014 were reviewed correlated presence donor-specific antibody (DSA). not different on any baseline...
In Brief Background Focal segmental glomerulosclerosis (FSGS) is a common cause of end-stage renal disease with high rate recurrence after kidney transplantation. Several factors, such as white race, rapid progression, and previous allograft failure due to recurrence, were found be risks recurrence. Data are limited on the benefits rituximab and/or therapeutic plasma exchange (TPE) in preventing this study, we sought assess efficacy TPE for prevention treatment recurrent FSGS Methods We...