A5001045429- T-cell and B-cell Immunology
- Anesthesia and Pain Management
- Hematopoietic Stem Cell Transplantation
- Immune Cell Function and Interaction
- Renal Transplantation Outcomes and Treatments
- Musculoskeletal pain and rehabilitation
- Immunotherapy and Immune Responses
- Anesthesia and Sedative Agents
- Particle physics theoretical and experimental studies
- Fibromyalgia and Chronic Fatigue Syndrome Research
- High-Energy Particle Collisions Research
- Quantum Chromodynamics and Particle Interactions
- Organ Transplantation Techniques and Outcomes
- Pain Mechanisms and Treatments
- Nausea and vomiting management
- Central Venous Catheters and Hemodialysis
- Immunodeficiency and Autoimmune Disorders
- Spine and Intervertebral Disc Pathology
- Chronic Lymphocytic Leukemia Research
- Acute Myeloid Leukemia Research
- Pain Management and Placebo Effect
- Organ Donation and Transplantation
- Blood groups and transfusion
- Pain Management and Opioid Use
- Lymphoma Diagnosis and Treatment
Uppsala University
2011-2023
Uppsala University Hospital
2004-2022
Linköping University
1984-2020
Engineering Link (Canada)
2020
Prevent Alzheimer’s Disease 2020
2020
The Swedish Hip Arthroplasty Register
2015
Science for Life Laboratory
2013
Karolinska University Hospital
2012
Linköping University Hospital
1988-2000
University of Oslo
1994
Central mechanisms related to referred muscle pain and temporal summation of muscular nociceptive activity are facilitated in fibromyalgia syndrome (FMS) patients. The present study assessed the effects an NMDA-antagonist (ketamine) on these central mechanisms. FMS patients received either i.v. placebo or ketamine (0.3 mg/kg, Ketalar®) given over 30 min two separate occasions. Habitual intensity was a visual analogue scale (VAS). Initially, 29 isotonic saline determine which were responders...
Donor-specific antibodies create an immunologic barrier to transplantation. Current therapies modify donor-specific are limited and ineffective in the most highly HLA-sensitized patients. The IgG-degrading enzyme derived from Streptococcus pyogenes (IdeS), endopeptidase, cleaves human IgG into F(ab')2 Fc fragments inhibiting complement-dependent cytotoxicity antibody-dependent cellular cytotoxicity, which suggests that IdeS might be useful for desensitization. We report on combined...
Pain intensity, muscle strength, static endurance, pressure pain threshold, and tolerance at tender points control were assessed in 31 patients with fibromyalgia (FM), before after intravenous administration of morphine (9 patients), lidocaine (11 ketamine patients). The three different studies double-blind placebo-controlled. classified as placebo-responders, responders (decrease intensity by > 50%) non-responders. test did not show any significant changes. showed a decrease during the...
A catalog of common, intermediate and well‐documented (CIWD) HLA‐A, ‐B, ‐C, ‐DRB1, ‐DRB3, ‐DRB4, ‐DRB5, ‐DQB1 ‐DPB1 alleles has been compiled from over 8 million individuals using data 20 unrelated hematopoietic stem cell volunteer donor registries. Individuals are divided into seven geographic/ancestral/ethnic groups summarized for each group the total population. P (two‐field) G assignments one four frequency categories: common (≥1 in 10 000), 100 (≥5 occurrences) or not‐CIWD. Overall 26%...
Immunotherapy (eg interferon α) in combination with tyrosine kinase inhibitors is currently clinical trials for treatment of chronic myeloid leukemia (CML). Cancer patients commonly have problems so called immune escape mechanisms that may hamper immunotherapy. Hence, to study the function system CML interest. In present paper we identified focus on those directly T cells since these are important control tumor progression. patient samples were investigated presence myeloid-derived...
Safety, immunogenicity, pharmacokinetics, and efficacy of the IgG-degrading enzyme Streptococcus pyogenes (IdeS [imlifidase]) were assessed in a single-center, open-label ascending-dose study highly sensitized patients with chronic kidney disease. Eight cytotoxic PRAs (median 64%) at enrollment received 1 or 2 intravenous infusions IdeS on consecutive days (0.12 mg/kg body weight ×2 [n = 3]; 0.25 ×1 3], 2]). IgG degradation was observed all subjects after treatment, <1% plasma remaining...
Background. Highly HLA sensitized patients have limited access to life-saving kidney transplantation because of a paucity immunologically suitable donors. Imlifidase is cysteine protease that cleaves IgG leading rapid decrease in antibody level and inhibition IgG-mediated injury. This study investigates the efficacy safety imlifidase converting positive crossmatch test negative, allowing highly be transplanted with living or deceased donor kidney. Methods. open-label, single-arm, phase 2...
Highly sensitized (HS) patients in need of kidney transplantation (KTx) typically spend a longer time waiting for compatible kidneys, are unlikely to receive an organ offer, and at increased risk antibody-mediated rejection (AMR). Desensitization using imlifidase, which is more rapid removes total body immunoglobulin G (IgG) greater extent than other methods, enables occur between HLA-incompatible (HLAi) donor-recipient pairs allows have access KTx. However, when the project was launched...
Twenty-eight patients with primary fibromyalgia participated in the study. Eight received a stellate ganglion blockade bupivacaine, and 14 days later an intravenous regional sympathetic guanethidine. The remaining served as controls were randomly allocated to receive either sham (placebo) injection physiologic saline superficial (n = 10) or bupivacaine intramuscularly 10). efficiency of was evaluated by measuring skin blood flow (using laser Doppler flowmeter), temperature, conductance...
Thyrostatic drug treatment of Graves' disease suppresses excessive thyroid hormone synthesis and causes a parallel decrease in serum autoantibody levels. The mechanism this immunosuppression is unknown. We studied methimazole-induced immunoregulatory effects prospectively 14 patients with treated for up to six months. numbers circulating activated, HLA-DR-positive T helper/inducer cells decreased gradually, from 8.3+1.7 percent (+SD) 1.0+1.7 (P less than 0.001). suppressor/cytotoxic...
The main aim of this study was to evaluate the significance HLA-DPB1 expression in acute graft-versus-host disease (GVHD) after hematopoietic cell transplantation (HCT) from HLA-A, -B, -C, -DRB1, -DQB1-matched and -mismatched unrelated donors.
ABSTRACT— Muscle fatigue is the most disabling symptom in primary fibromyalgia (PF), which addition characterized by generalised pain and muscle stiffness. In order to assess whether of central and/or peripheral origin, skeletal function was studied measuring maximum voluntary hand grip strength, various contraction characteristics adductor pollicis after electrical stimulation ulnar nerve. The PF-patients were also a regional sympathetic blockade forearm with guanethidine. A lower strength...
The number of allogeneic hematopoietic stem cell (HSC) transplants performed globally each year continues to increase. Advances in HLA typing, better supportive care, and administration reduced-intensity conditioning regimens allow treatment older patients with sibling donors. Pretransplant donor assessment testing are very important processes affecting the quality safety donation. For unrelated HSC donors detailed recommendations for health have been published, allowing donation only if...