A5101758375- Peripheral Neuropathies and Disorders
- Autoimmune Neurological Disorders and Treatments
- Herpesvirus Infections and Treatments
- Cardiac Valve Diseases and Treatments
- Cardiac pacing and defibrillation studies
- Clostridium difficile and Clostridium perfringens research
- Immunodeficiency and Autoimmune Disorders
- Microscopic Colitis
- Reproductive tract infections research
- Antibiotics Pharmacokinetics and Efficacy
- Blood disorders and treatments
- Potassium and Related Disorders
Uppsala University
2015-2018
Stockholm County Council
2013
Background. Despite the proven efficacy of acyclovir (ACV) therapy, herpes simplex encephalitis (HSE) continues to cause substantial morbidity and mortality. Among patients with HSE treated ACV, mortality rate is approximately 14%–19%. survivors, 45%–60% have neuropsychological sequelae at 1 year. Thus, improving therapeutic approaches remains a high priority. Methods. Following completion standard course intravenous 87 adult (confirmed by positive polymerase chain reaction [PCR] for virus...
Safety, immunogenicity, pharmacokinetics, and efficacy of the IgG-degrading enzyme Streptococcus pyogenes (IdeS [imlifidase]) were assessed in a single-center, open-label ascending-dose study highly sensitized patients with chronic kidney disease. Eight cytotoxic PRAs (median 64%) at enrollment received 1 or 2 intravenous infusions IdeS on consecutive days (0.12 mg/kg body weight ×2 [n = 3]; 0.25 ×1 3], 2]). IgG degradation was observed all subjects after treatment, <1% plasma remaining...
<h3>Background</h3> The advent of gene amplification testing methods for Neisseria gonorrhoea has lead to a higher prevalence in the population. Various Nucleic Acid Amplification Tests (NAAT) are used, often with high specificity. sensitivity culture is substantially lower than NAAT. Before treatment initiated, antibiotic isolate should be determined using culture-based methods. A considerable proportion cases positive NAAT cannot verified by and hence it not possible verify diagnosis or...