A5068116723- Lipoproteins and Cardiovascular Health
- Blood Pressure and Hypertension Studies
- Health Systems, Economic Evaluations, Quality of Life
- Respiratory and Cough-Related Research
- Hormonal Regulation and Hypertension
- Asthma and respiratory diseases
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Nutritional Studies and Diet
- Diet and metabolism studies
- Pharmacology and Obesity Treatment
- Renin-Angiotensin System Studies
- Fatty Acid Research and Health
- Anesthesia and Sedative Agents
- Renal and Vascular Pathologies
- Antibiotic Use and Resistance
- Receptor Mechanisms and Signaling
- Vitamin K Research Studies
- Cholesterol and Lipid Metabolism
- Cardiovascular Health and Disease Prevention
- Intensive Care Unit Cognitive Disorders
- Heart Failure Treatment and Management
- Pharmaceutical Economics and Policy
- Sodium Intake and Health
- Health Promotion and Cardiovascular Prevention
- Social Media in Health Education
Chinese University of Hong Kong
2023
University of Wollongong
2012-2019
Illawarra Health and Medical Research Institute
2012-2019
Wollongong Hospital
2017-2019
Illawarra Shoalhaven Local Health District
2016-2019
Shellharbour Hospital
2017
RMIT University
2008
Royal Hallamshire Hospital
1993-2007
University of Sheffield
1992-2006
Osaka University
2003
A trial involving adults 50 years of age or older (ZOE-50) showed that the herpes zoster subunit vaccine (HZ/su) containing recombinant varicella-zoster virus glycoprotein E and AS01B adjuvant system was associated with a risk 97.2% lower than placebo. second performed concurrently at same sites examined safety efficacy HZ/su in 70 (ZOE-70).This randomized, placebo-controlled, phase 3 conducted 18 countries involved older. Participants received two doses placebo (assigned 1:1 ratio)...
atrial fibrillation (AF) is the commonest chronic arrhythmia with a prevalence of 9% in octogenarians and accounts for 24% stroke risk this population. Although trials demonstrate reductions warfarin, audit data show that it still underused. However, anti-coagulation very elderly not without risk.randomised open labelled prospective study primary thromboprophylaxis AF. Patients aged >80 <90 were randomised to receive dose-adjusted warfarin (INR 2.0-3.0) or aspirin 300 mg. All patients had...
<h3>Objective</h3> To examine the validity of estimates coronary heart disease (CHD) risk by Framingham function, for European populations. <h3>Design</h3> Comparison CHD individuals derived from Framingham, prospective cardiovascular Münster (PROCAM), Dundee, and British regional (BRHS) functions. <h3>Setting</h3> Sheffield Hypertension Clinic. Patients—206 consecutive hypertensive men aged 35–75 years without preexisting vascular disease. <h3>Results</h3> There was close agreement among...
OBJECTIVE--To evaluate the long term efficacy of diets in lowering serum cholesterol concentration. DESIGN--Descriptive overview 16 published controlled trials six months9 duration or longer. SETTING--Trials had been conducted hospital clinics (6), industry (3), mental hospitals institutions and general populations (4). PATIENTS--Trials high risk subjects (5), unselected healthy for secondary prevention patients with coronary heart disease (5). Women were included only four trials....
The prostanoid, PGE2, is known to inhibit human lung mast cell activity. aim of the present study was characterize EP receptor that mediates this effect. PGE2 (pEC(50), 5.8+/-0.1) inhibited IgE-mediated release histamine from cells in a concentration-dependent manner. Alternative agonists were studied. EP2-selective agonist, butaprost (pEC50, 5.2+/-0.2), an effective inhibitor mediator whereas EP1/EP3 sulprostone, and EP1-selective 17-phenyl-trinor-PGE2, ineffective. DP agonist PGD2, FP...
Aims Cardiovascular disease caused by smoking is related to the pathophysiological burden placed on vascular endothelium. We studied effect of chronic cigarette arterial wave reflection (study 1) and cessation pulse analysis 2). Methods Fifty smokers 50 age‐ sex‐matched nonsmokers participated in study 1. Study 2 recruited 20 volunteers from stop clinic at Royal Hallamshire Hospital, Sheffield, UK. Systemic augmentation index (AIx) carotid‐femoral velocity (PWV) were measured using...
<h3>OBJECTIVES</h3> To estimate the cost effectiveness of statin treatment in preventing coronary heart disease (CHD) and to examine effect CHD risk level targeted statins on treatment. <h3>DESIGN</h3> Cohort life table method using data from outcome trials. <h3>MAIN OUTCOME MEASURES</h3> The per year gained for lifelong at annual event risks 4.5% (secondary prevention) 3.0%, 2.0%, 1.5% (all primary prevention), with varied £100 £800 year. <h3>RESULTS</h3> costs according were: 4.5%, £5100;...
To determine the effects of beta 1 selective adrenoceptor blocker atenolol, dihydropyridine calcium antagonist nifedipine, and combination atenolol plus nifedipine on objective subjective measures walking performance foot temperature in patients with intermittent claudication.Randomised controlled double blind four way crossover trial.Royal Hallamshire Hospital, Sheffield.49 (40 men) aged 39-70 chronic stable claudication.Atenolol 50 mg twice daily; slow release 20 placebo. Each treatment...
The ZOE-50 (NCT01165177) and ZOE-70 (NCT01165229) phase 3 clinical trials showed that the adjuvanted recombinant zoster vaccine (RZV) was ≥90% efficacious in preventing herpes adults. Here we present a comprehensive overview of safety data from these studies.Adults aged ≥50 (ZOE-50) ≥70 (ZOE-70) years were randomly vaccinated with RZV or placebo. Safety analyses performed on pooled total cohort, consisting participants receiving at least one dose Solicited unsolicited adverse events (AEs)...
Inhalation cough challenge has become an accepted method of investigating antitussive agents. It is, therefore, important to examine the degree tachyphylaxis seen with repeated challenge. In addition, different types may reveal differences in neuronal pathways involved reflex. Citric acid, distilled water and capsaicin were examined determine adaptation response during acute long-term inhalation studies healthy subjects. To study two separate one minute continuous challenges (n = 13)...
To determine the effects of verapamil and diltiazem on simvastatin metabolism in human liver microsomes to compare their inhibitory potencies CYP3A4 inactivation parameters with those reported previously for mibefradil.
1. Recent outcome trials suggest that lipid-lowering with 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors is justifiable on risk-benefit grounds in subjects serum cholesterol &gt;5.5mmol/l who have coronary heart disease, other forms of atherosclerotic vascular or are free disease but a risk major events ≥ 1.5% per year. Choice an appropriate treatment policy will require (i) knowledge the proportion population need for secondary prevention, and (ii) targeting primary...
Background: Studies evaluating antimicrobial stewardship programmes (ASPs) supported by computerized clinical decision support systems (CDSSs) have predominantly been conducted in single site metropolitan hospitals. Objectives: To examine outcomes of multisite ASP implementation a centrally deployed CDSS. Methods: An interrupted time series study was across five hospitals New South Wales, Australia, from 2010 to 2014. Outcomes analysed were: effect the intervention on targeted use, costs and...
Background: Traditional approaches to health professional education are being challenged by increased clinical demands and decreased available time. Web-based e-learning tools offer a convenient effective method of delivering education, particularly across multiple care facilities. The effectiveness this model for needs be explored in context.
1. The effects of a single oral dose enalapril 10 mg on serum ACE activity and blood pressure in relation to the genotype were studied 27 healthy men, n = 9 each DD, ID II, parallel group study design. 2. Before treatment differed significantly between genotypes, with 56% higher DD than II subjects, explaining 40% between‐subject variance activity. 3. After absolute fall was larger subjects at 2, 4, 6 h (by 9.0 (95% CI 0.7‐17.2), 10.7 (3.8‐17.6), 9.7 (2.8‐16.6) nmol ml‐1 min‐1 respectively),...
The beta adrenergic agonist isoprenaline inhibited the IgE-triggered release of preformed mediator histamine from human lung mast cells (HLMC) in a dose-dependent fashion. After prolonged (> or = 4 h) preexposure HLMC to isoprenaline, there was subsequent diminution effectiveness second exposure inhibit activated HLMC. This induced hyporesponsiveness both concentration and time dependent. Although maximal levels desensitization were obtained after an initial (14-h) preincubation with high...