A5003072989- Acute Myeloid Leukemia Research
- Hematopoietic Stem Cell Transplantation
- Acute Lymphoblastic Leukemia research
- Gut microbiota and health
- Protein Degradation and Inhibitors
- Immune Cell Function and Interaction
- Genomics, phytochemicals, and oxidative stress
- Cancer Immunotherapy and Biomarkers
- Multiple Myeloma Research and Treatments
- RNA Interference and Gene Delivery
- IL-33, ST2, and ILC Pathways
- Epigenetics and DNA Methylation
- Cancer Genomics and Diagnostics
- Myeloproliferative Neoplasms: Diagnosis and Treatment
Washington University in St. Louis
2021-2024
Saint Louis University
2023
University of Michigan
2020-2022
There is increasing evidence that gut microbiome perturbations, also known as dysbiosis, can influence colorectal cancer development. To understand the mechanisms by which modulates susceptibility, we examine two wild-type mouse colonies with distinct microbial communities develop significantly different tumor numbers using a model of inflammation-associated tumorigenesis. We demonstrate adaptive immune cells contribute to susceptibilities associated communities. Mice more tumors have...
MLL rearrangements ( r) are the most common cause of congenital and infant leukemias. r arise prior to birth require few cooperating mutations for transformation, yet leukemias 10-fold less than >100-fold childhood overall. This raises question whether mechanisms exist suppress leukemic transformation during fetal life, thereby protecting developing fetus from malignancy a period rapid hematopoietic progenitor expansion. Here, we use mouse models show that MLL::ENL exposure creates...
Abstract Acute myeloid leukemia (AML) initiation requires multiple rate-limiting mutations to cooperatively reprogram progenitor cell identity. For example, FLT3 internal tandem duplication (FLT3ITD) cooperate with a variety of different initiating fate. These often skew toward either pediatric or adult AML patient populations, though FLT3ITD itself occurs at similar frequencies in both age groups. This raises the question whether might induce distinct transcriptional programs and unmask...
Sulforaphane is a bioactive metabolite with anti-inflammatory activity that derived from glucosinolates, which are highly abundant in cruciferous vegetables including broccoli sprouts. There have been limited studies to investigate whole foods approach increase sulforaphane levels therapeutic effect and reduce inflammation. In the current study, using mouse model of inflammatory bowel disease, we aimed ability steamed sprouts ameliorate colitis role microbiota mediating any effects. C57BL/6J...