A5097274353- Toxin Mechanisms and Immunotoxins
- Herpesvirus Infections and Treatments
- RNA regulation and disease
- Poxvirus research and outbreaks
University of Würzburg
2021-2024
ABSTRACT Transcriptional activity of RNA polymerase II (Pol II) is influenced by post-translational modifications the C-terminal domain (CTD) largest Pol subunit, RPB1. Herpes simplex virus type 1 (HSV-1) usurps cellular transcriptional machinery during lytic infection to efficiently express viral mRNA and shut down host gene expression. The immediate-early protein ICP22 interferes with serine 2 phosphorylation (pS2) targeting CDK9 other CDKs, but full functional implications this are not...
Abstract Transcriptional activity of RNA polymerase II (Pol II) is orchestrated by post-translational modifications the C-terminal domain (CTD) largest Pol subunit, RPB1. Herpes Simplex Virus type 1 (HSV-1) usurps cellular transcriptional machinery during lytic infection to efficiently express viral mRNA and shut down host gene expression. The immediate-early protein ICP22 interferes with serine 2 phosphorylation (pS2) CTD targeting CDK9. functional implications this are poorly understood....