A5058125949- MicroRNA in disease regulation
- Cancer-related Molecular Pathways
- Neurobiology and Insect Physiology Research
- Advanced Breast Cancer Therapies
- Insect and Arachnid Ecology and Behavior
- Plant and animal studies
- Insect and Pesticide Research
- Microtubule and mitosis dynamics
- Genomics and Chromatin Dynamics
- Ubiquitin and proteasome pathways
- Cytokine Signaling Pathways and Interactions
- Insect Pheromone Research and Control
- Immune cells in cancer
- DNA Repair Mechanisms
- Plant Molecular Biology Research
- Epigenetics and DNA Methylation
- RNA regulation and disease
- Retinoids in leukemia and cellular processes
- Toxin Mechanisms and Immunotoxins
- Asthma and respiratory diseases
- Histone Deacetylase Inhibitors Research
- Chromosomal and Genetic Variations
- Protein Tyrosine Phosphatases
- Chemokine receptors and signaling
- Invertebrate Immune Response Mechanisms
University of Würzburg
2024
Universität Innsbruck
2017-2019
University of Hohenheim
2012-2017
North Carolina State University
2006-2010
RWTH Aachen University
2004
Abstract On human macrophages IL-10 acts as a more potent anti-inflammatory cytokine than IL-6, although both cytokines signal mainly via activation of the transcription factor STAT3. In this study we compare and IL-6 signaling in primary derived from blood monocytes. Pretreatment with PMA or proinflammatory mediators LPS TNF-α blocks IL-6-induced STAT3 activation, whereas IL-10-induced remains largely unaffected. Although induces feedback inhibitor suppressor 3 (SOCS3) macrophages,...
The immediate early response of cells treated with IL-6 (interleukin-6) is the activation signal transducer and activator transcription (STAT)3. Src homology domain 2 (SH2)-containing protein tyrosine phosphatase SHP2 feedback inhibitor SOCS3 (suppressor cytokine signalling) are potent inhibitors transduction. Impaired function or leads to enhanced prolonged signalling. inhibitory both proteins depends on their recruitment motif 759 within glycoprotein gp130. In contrast inactivation,...
Abstract Moth sexual communication systems are highly diverse, but the mechanisms underlying their evolutionary diversification remain unclear. Recently, genes coding for odorant receptors (ORs) OR6 , OR14 OR15 and OR16 have been genetically associated with species‐specific male response to female pheromone blends in Heliothis virescens (Hv) subflexa (Hs). Quantitative real‐time PCR analysis indicates that expression of HvOR6 HsOR6 HvOR14 HsOR14 HvOR15 HsOR15 is biased, which supports...
In multicellular organisms, growth and proliferation is adjusted to nutritional conditions by a complex signaling network. The Insulin receptor/target of rapamycin (InR/TOR) cascade plays pivotal role in nutrient dependent regulation Drosophila mammals alike. Here we identify Cyclin G (CycG) as regulator metabolism Drosophila. CycG mutants have reduced body size weight show signs starvation accompanied disturbed fat metabolism. InR/TOR activity impaired cycG mutants, combined with...
Cyclin G (CycG) belongs to the atypical cyclins that have diverse cellular functions. The two mammalian CycG genes, CycG1 and CycG2, regulate cell cycle in response stress. Detailed analyses of role single Drosophila cycG gene been hampered by lack a mutant. We generated null mutant is female sterile produces ventralized eggs. This phenotype typical downregulation EGFR signalling during oogenesis. Ventralized eggs are also observed mutants defective meiotic DNA double-strand break repair,...
ABSTRACT Transcriptional activity of RNA polymerase II (Pol II) is influenced by post-translational modifications the C-terminal domain (CTD) largest Pol subunit, RPB1. Herpes simplex virus type 1 (HSV-1) usurps cellular transcriptional machinery during lytic infection to efficiently express viral mRNA and shut down host gene expression. The immediate-early protein ICP22 interferes with serine 2 phosphorylation (pS2) targeting CDK9 other CDKs, but full functional implications this are not...
Size and weight control is a tightly regulated process, involving the highly conserved Insulin receptor/target of rapamycin (InR/TOR) signaling cascade. We recently identified Cyclin G (CycG) as an important modulator InR/TOR activity in Drosophila. cycG mutant flies are underweight show disturbed fat metabolism resembling TOR mutants. In fact, mutants at level Akt1, central kinase linking InR TORC1. Akt1 negatively by protein phosphatase PP2A. Notably binding PP2A B′-regulatory subunit...
In general, cyclins control the cell cycle. Not so atypical cyclins, which are required for diverse cellular functions such as genome stability or regulation of transcription and translation. The Cyclin G (CycG) gene Drosophila has been involved in epigenetic abdominal segmentation, proliferation growth, based on overexpression RNAi studies, but detailed analyses were hampered by lack a cycG mutant. For further investigations, we subjected locus to molecular analysis. Moreover, studied null...
One of the key players in genome surveillance is tumour suppressor p53 mediating adaptive response to a multitude stress signals. Here we identify Cyclin G (CycG) as co-factor p53-mediated stability. CycG has been shown before be involved double-strand break repair during meiosis. Moreover, it also important for DNA damage somatic tissue. find protein complexes together with p53, and show that two proteins interact physically vitro vivo ionizing irradiation. In contrast mammals, Drosophila...
FoxH1 is a forkhead transcription factor with conserved key functions in vertebrate mesoderm induction and left-right patterning downstream of the TGF-beta/Nodal signaling pathway. Binding domain (FHD) to highly proximal sequence motif was shown regulate target gene expression. We identify microRNA-430 family (miR-430) as novel FoxH1. miR-430 levels are increased foxH1 mutants, resulting reduced expression transcripts that targeted by for degradation. To determine underlying mechanism...