A5024386153- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Esophageal Cancer Research and Treatment
- Gastric Cancer Management and Outcomes
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Esophageal and GI Pathology
- Radiopharmaceutical Chemistry and Applications
- Medical Imaging Techniques and Applications
- Pancreatic and Hepatic Oncology Research
- Radiomics and Machine Learning in Medical Imaging
- Retinoids in leukemia and cellular processes
- Cancer Immunotherapy and Biomarkers
- Prostate Cancer Treatment and Research
- ATP Synthase and ATPases Research
- Cancer, Hypoxia, and Metabolism
- Ultrasound and Hyperthermia Applications
- Cardiac Imaging and Diagnostics
- Autophagy in Disease and Therapy
- Eicosanoids and Hypertension Pharmacology
Henan Cancer Hospital
2018-2024
Zhengzhou University
2018-2024
Creative Commons
2018
First Affiliated Hospital of Zhengzhou University
2013
MicroRNAs (miRNAs) have been integrated into cancer development and progression, because they repress translation of target genes which can be tumor suppressors oncogenes. A number miRNAs found to closely related human non-small cell lung (NSCLC). However, the roles miR-136 in NSCLC are still largely unknown. Here, we show that is significantly upregulated primary tumors lines compared their nontumor counterparts. Suppression expression line A549 inhibited both anchorage-dependent...
Accumulating evidence has established that long noncoding RNA (lncRNA) plasmacytoma variant translocation 1 (PVT1) is a tumor regulator in many cancers. Here, we aimed to investigate the possible function of lncRNA PVT1 esophageal carcinoma (EC) via targeting microRNA-145 (miR-145). Initially, microarray-based gene expression profiling EC was employed identify differentially expressed genes. Moreover, examined and cell line presenting with highest level selected for subsequent experiments....
The interaction of long non-coding RNAs (lncRNAs), microRNAs (miRNAs), and mRNAs has been implicated in various types cancers, including esophageal cancer (EC). current study aimed to investigate the role AGAP2-AS1/miR-195-5p/Fos-like antigen-1 (FOSL1) EC progression. expression AGAP2-AS1, miR-195-5p, FOSL1 tumor tissues isolated from patients cell lines was determined by quantitative reverse transcriptase polymerase chain reaction (qRT-PCR), results which illustrated that AGAP2-AS1 were...
Homeobox D gene cluster antisense growth-associated long noncoding RNA (HAGLR) functions as a crucial regulator in the progression and development of human cancers. We analyzed effects HAGLR, microRNA (miR)-143-5p lysosome-associated membrane glycoprotein (LAMP)3 on esophageal cancer (EC) related mechanisms. Microarray analysis was used to screen out EC-related genes regulation network among miR-143-5p, LAMP3. The regulatory mechanisms HAGLR miR-143-5p EC were following treatment mimic,...
Neoadjuvant chemotherapy (NAC) and neoadjuvant chemoradiotherapy (NACR) are the standard treatments for esophageal squamous cell carcinoma (ESCC). However, 5-year overall survival (OS) rate is still far from satisfactory. In recent years, immune checkpoint inhibitors (ICIs) have shown promising results in treatment of ESCC. More than 20 phase II clinical trials been launched to explore combinations ICIs setting Based on our trial, a two-arm III trial was Henan Cancer Hospital. combined with...
Abstract Background In the era of immunotherapy, neoadjuvant immunochemotherapy (NAIC) for treatment locally advanced esophageal squamous cell carcinoma (ESCC) is used clinically but lacks high‐level clinical evidence. This study aimed to compare safety and long‐term efficacy NAIC followed by minimally invasive esophagectomy (MIE) with those chemotherapy (NAC) MIE. Methods A prospective, single‐center, open‐label, randomized phase III trial was conducted at Henan Cancer Hospital, Zhengzhou,...
Esophageal cancer represents the eighth most frequently occurring cancer, as well sixth widespread cause of cancer-related deaths. In recent years, accumulating evidence has implicated long non-coding RNAs in progression esophageal squamous cell carcinoma (ESCC). The aim present study was to investigate potential involvement and underlying mechanisms LINC00337 ESCC. Expression patterns targeting protein for Xenopus kinesin-like 2 (TPX2) ESCC tissues cells were detected using RT-qPCR...
Long non-coding RNA (lncRNA) plasmacytoma variant translocation 1 (PVT1) is correlated to various malignant tumors. Consequently, we explored effects of lncRNA PVT1 on esophageal carcinoma (EC) targeting microRNA-145 (miR-145). EC tissues, adjacent normal and EC-related cell lines were collected cultured. Expression PVT1, miR-145, fascin-1 (FSCN1), related genes with intervening expression miR-145 was determined. Bioinformatic website, dual-luciferase reporter assay, immunoprecipitation...
20003 Background: Previous clinical trials of 131I-chlorotoxin in patients with recurrent glioblastoma multiforme administered this targeted peptide locally into a tumor resection cavity. In trial the distribution intravenous (IV) was examined to determine if IV route administration would be feasible and show intratumoral uptake metastatic melanoma including metastases CNS. Materials Methods: Seven were enrolled prospective that also included other advanced solid tumors. The are subject...
Objective: To investigate whether CT coronary angiography (CTA) can safely and effectively reduce the number of invasive (ICA) in patients with non-ST-segment elevation myocardial infarction (NSTEMI) whose Grace score is low-or moderate-risk, increase ICA positive rate. Methods: One hundred two NSTEMI patients, including 61 males 41 females, aged 38-80 (58±12) years, were prospectively included treated Henan Provincial People's Hospital from February 2017 to 2018. By using random method,...
Background: In the age of immunotherapy, CheckMate 577 had changed standard adjuvant treatment resectable esophageal caner. To our knowledge, there were no large scale stage III clinical trials reported neoadjuvant immunochemotherapy for squamous cell carcinoma(ESCC). Therefore, this interim analysis was conducted to add new evidence ESCC.Methods: single-center, open-label, phase 3 trial(Henan Cancer Hospital, Zhengzhou, China), patients with ESCC randomly assigned receive toripalimab and...
Objective To investigate the effects of microRNA (miRNA, miR)-136 on A549 cells proliferation. Methods (1) The expression miR-136 in and 16HBE was detected by reverse transcriptase-polymerase chain reaction (RT-PCR). 40 nmol/L inhibitor transfected into cells, effect inhibition RT-PCR. (2) Cell proliferation tested methyl thiazol tetrazolium (MTT) assay soft agar assay. (3) 20 extracellular signal-regulated kinase 1/2 (ERK1/2) signaling pathway determined Western...
Background: The involvement of long non-coding RNAs (lncRNAs) has been highlighted in multiple cancers including esophageal cancer (EC). Differentially expressed Our study aims to figure out the role AGAP2-AS1/microRNA-195-5p (miR-195-5p)/FOSL1 EC progression.Methods: expression AGAP2-AS1, miR-195-5p and FOSL1 tissues cell lines were determined. After that, ectopic knockdown applied explore effect AGAP2-AS1/miR-195-5p/FOSL1 on proliferation, cycle apoptosis, as well invasion migration....