A5101483725- Quantum Mechanics and Non-Hermitian Physics
- Advanced Polymer Synthesis and Characterization
- Chemical Synthesis and Analysis
- Multiple Myeloma Research and Treatments
- Mechanical and Optical Resonators
- Quantum chaos and dynamical systems
- Near-Field Optical Microscopy
- Electron Spin Resonance Studies
- Nonlinear Waves and Solitons
- Electrospun Nanofibers in Biomedical Applications
- Orbital Angular Momentum in Optics
- Polymer Surface Interaction Studies
- Astrophysical Phenomena and Observations
- HER2/EGFR in Cancer Research
- Monoclonal and Polyclonal Antibodies Research
- Pulsars and Gravitational Waves Research
- CCD and CMOS Imaging Sensors
- Ocular and Laser Science Research
- Geophysics and Sensor Technology
- Advanced biosensing and bioanalysis techniques
- Plant Reproductive Biology
- Advanced Optical Sensing Technologies
- X-ray Spectroscopy and Fluorescence Analysis
- Molecular spectroscopy and chirality
- Block Copolymer Self-Assembly
Massachusetts Institute of Technology
2018-2024
South China Normal University
2020-2024
Integrated Optoelectronics (Norway)
2024
Duke University
2023
Jiangnan University
2020
Having a compact yet robust structurally based identifier or representation system is key enabling factor for efficient sharing and dissemination of research results within the chemistry community, such systems lay down essential foundations future informatics data-driven research. While substantial advances have been made small molecules, polymer community has struggled in coming up with an system. This because, unlike other disciplines chemistry, basic premise that each distinct chemical...
Deciphering the significance of length, sequence, and stereochemistry in block copolymer self-assembly remains an ongoing challenge. A dearth methods to access uniform co-oligomers/polymers with precise stereochemical sequences has precluded such studies. Here, we develop iterative exponential growth for synthesis a small library unimolecular stereoisomeric diblock 32-mers. X-ray scattering reveals that modulates phase behavior these polymers, which rationalize based on simulations carried...
Conjugates of proteins and bottlebrush polymers are prepared using an “organometallic swap” strategy.
Nitroxide-based organic-radical contrast agents (ORCAs) are promising as safe, next-generation magnetic resonance imaging (MRI) tools. Nevertheless, stimuli-responsive ORCAs that enable MRI monitoring of prodrug activation have not been reported; such systems could open new avenues for validation and image-guided drug delivery. Here, we introduce a novel "pro-ORCA" concept addresses this challenge. By covalent conjugation nitroxides molecules (doxorubicin, DOX) to the same brush-arm star...
Polymer conjugation has been widely used to improve the stability and pharmacokinetics of therapeutic biomacromolecules; however, conventional methods generate such conjugates often use disperse and/or achiral polymers with limited functionality. The heterogeneity may lead manufacturing variability, poorly controlled biological performance, ability optimize structure-property relationships. Here, using insulin as a model polypeptide, we introduce strategy for synthesis polymer-protein based...
The impact of strand molecular length on mechanical response is elucidated through the incorporation uniform mechanochromic force probes.
Antibody drug conjugates (ADCs), which feature a monoclonal antibody (mAb) for cell targeting linked to cytotoxic payload killing, are remarkably effective class of targeted therapeutics. Despite their success, however, ADCs typically rely on highly potent payloads, precluding the use less payloads and broader range mechanisms action (MoA).1-4 Moreover, emerging perspective that passive play roles in ADC function vivo suggests opportunities engineer new based stable prodrug scaffolds with...
Our recent research on type-I quadrature parity-time (PT) symmetry, utilizing an open twin-beam system, not only enables observing genuine quantum photonic PT symmetry amid phase-sensitive amplification (PSA) and loss in the presence of Langevin noise but also reveals additional classical-to-quantum (C2Q) transitions relative-intensity fluctuations. In contrast to previous setup, our exploration alternative system assuming no involves a type-II PSA-only scheme. This scheme facilitates dual...
Over the past decade, parity-time (PT) symmetry and anti-PT (APT) in various physical systems have been extensively studied, leading to significant experimental theoretical advancements. However, that simultaneously exhibit both PT APT not yet explored. In this study, we construct a phase-sensitive non-Hermitian wave mixing model inherently possesses single-mode symmetry. By tuning phase of pump field, exhibits two-mode quadrature-PT Moreover, transition is accompanied by emergence quantum...
Our recent research on type-I quadrature parity-time (PT) symmetry, utilizing an open twin-beam system, not only enables observing genuine quantum photonic PT symmetry amid phase-sensitive amplification (PSA) and loss in the presence of Langevin noise but also reveals additional classical-to-quantum (C2Q) transition fluctuations. In contrast to previous setup, our exploration alternative system assuming no involves a type-II PSA-only scheme. This scheme facilitates dual opposing...
We have theoretically investigated the use of a simple combined amplitude structure to produce sub-diffracted Bessel beam via diffraction interference. This powerful is composed spiral slit and radial grating. When vortex illuminates this structure, subwavelength with size 0.39λ long working distance approximately 100 µm numerically realized. By tailoring parameters slit, we can obtain longer beam. Moreover, observed has low-energy side-lobes. The peculiar features our generated numerous...
Quantum Langevin noise makes experimental realization of genuine quantum-optical parity-time (PT) symmetry in a gain-loss-coupled open system elusive. Here, we challenge this puzzle by exploiting twin beams produced from nonlinear parametric process, one undergoing phase-sensitive linear quantum amplification (PSA) and the other engaging balanced loss merely. Unlike all previous studies involving phase-insensitive (PIA), our PSA-loss scheme allows quadrature pair to experience PT symmetry,...
Quantum Langevin noise makes the observation of quantum-optical parity-time (PT) symmetry in an open system with both gain and loss elusive. Here, we challenge this problem by exploiting twin beams produced from a nonlinear parametric process, one undergoing phase-sensitive linear quantum amplification (PSA) other engaging balanced merely. Unlike previous studies involving phase-insensitive (PIA), our PSA-loss scheme enables only pair quadratures to evolve PT-symmetrically variances...
Semiconductor photon up-converter that can convert infrared to visible light has great application potential in area of new type imaging, photoelectric alarming, and atmospheric monitoring. Based on its working mechanism, this paper introduced the types up-convert sensor, displayed advantage when it was applied imaging. This also gave a detailed review about development semiconductor recent years. The organic-inorganic hybrid method suitably combine superiority both material systems...
A new system has been developed for efficient calibration of modern space soft x-ray astronomical telescopes, in particular the detectors with energy and time resolution. The provides a large-area (about 1000 cm<sup>2</sup> ), highly parallel (±1mrad/24mm), timely spatially uniform (±5%) beam beam. Other special features include multianode (15 anodes 17 filters) source narrower pulse (width ≤10 ns) source. There is six-axes vacuum turntable that can be used wide range high...