A5102882821- Lymphoma Diagnosis and Treatment
- Cell death mechanisms and regulation
- Acute Myeloid Leukemia Research
- Histiocytic Disorders and Treatments
- Chronic Lymphocytic Leukemia Research
- NF-κB Signaling Pathways
- PI3K/AKT/mTOR signaling in cancer
- Metal complexes synthesis and properties
- Phytochemistry and biological activity of medicinal plants
- Synthesis of β-Lactam Compounds
- Diagnosis and Treatment of Venous Diseases
- Blood Coagulation and Thrombosis Mechanisms
- Histone Deacetylase Inhibitors Research
- Pharmacological Effects of Natural Compounds
- Neurosurgical Procedures and Complications
- Viral-associated cancers and disorders
- Gastrointestinal Tumor Research and Treatment
- Pharmacogenetics and Drug Metabolism
- interferon and immune responses
- Bone Tumor Diagnosis and Treatments
- CNS Lymphoma Diagnosis and Treatment
- Central Venous Catheters and Hemodialysis
- Eosinophilic Disorders and Syndromes
- Multiple Myeloma Research and Treatments
- Myeloproliferative Neoplasms: Diagnosis and Treatment
Aneurin Bevan University Health Board
2025
Swansea Bay University Health Board
2013-2020
Morriston Hospital
2020
University Hospital of Wales
2013-2017
Cardiff University
2006-2015
University of Manchester
2006
ABSTRACT Introduction Myeloproliferative neoplasms (MPNs), such as polycythaemia vera (PV), essential thrombocythemia (ET) and myelofibrosis (MF), are primarily treated by managing blood counts to reduce the thrombotic risk using cytoreductive agents. Busulphan, an oral alkylating agent, has been historically used for MPN management due its myelosuppressive effects, but concerns about of leukaemic transformation have limited use. Methods This real‐world retrospective study evaluated safety...
Salicylates are novel biologically active compounds that exhibit multiple therapeutic activities. The anti-cancer effectiveness of calcium salicylate has been investigated on human HT-1080 fibrosarcoma cell lines at relatively low concentrations (predominantly 0.4 mM) compared to those previously reported. Although did not retard tumour growth progression significantly, as measured by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and time-lapse assays, its cytotoxic...
Non-steroidal anti-inflammatory drugs have been shown to induce apoptosis in primary B-cell chronic lymphocytic leukaemia (CLL) cells, but the molecular mechanisms that underpin this observation not fully elucidated. Here, we analysed effect two novel aspirin analogues, 2-hydroxy benzoate zinc (2HBZ) and 4-hydroxy (4HBZ), on CLL samples.Cytotoxic effects of 2HBZ 4HBZ were cells derived from 52 patients, normal B- T-lymphocytes. Mechanisms action these agents also elucidated.Both analogues...
We report the case of a previously well 58-year-old man who presented with headache and confusion 4 days postadministration intrathecal methotrexate. He was undergoing intensive chemotherapy (CODOX-M/IVAC, cyclophosphamide, doxorubicin, vincristine, methotrexate, etoposide, ifosfamide, cytarabine) for treatment leukaemic phase CD20 negative diffuse large B-cell lymphoma. A CT head demonstrated presence bilateral subdural hygromas complicated by haemorrhage resulting from coexisting induced...
Abstract Objectives: To examine the effect of a novel phenolic‐based compound, 2‐hydroxy benzoate zinc (2HBZ), and acetylsalicylic acid (ASA) on human HT‐1080 fibrosarcoma cells. Materials methods: MTT assay was used to assess cell proliferation while different methods were detect apoptosis morphologically immunohistochemically in Human Apoptosis determined by Annexine‐V labelling, caspase‐3 activation. In addition, western blot analyse p21, p53 Bax flow cytometry cycle. Results: 2HBZ...
A 15-year-old boy with McCune–Albright syndrome (MAS) presented progressive anaemia and thrombocytopenia: haemoglobin concentration (Hb) 72 g/l, platelet count 13 × 109/l, white cell (WBC) 8·4 109/l. Two years previously his blood had been normal. Clinical examination showed splenomegaly, the spleen measuring 20 cm on a computed tomography scan. His film was leucoerythroblastic bone marrow aspirate showing only few nucleated cells. Bone biopsy sections hypocellularity mixture of marked...
The organism is common within all environments with stagnant high temperature water sources a favourable medium for growth. This infection almost exclusively found in the immuno-compromised population, usually presenting skin ulcers. Patients rarely have abscesses, sinus tract and pulmonary manifestations. treatment of invasive M. chelonae not well established mortality high. In vitro susceptibility does predict effectiveness appropriate duration unclear. Appropriate microbiological methods...
Better outcomes for patients with acute myeloid leukemia over the last 30 years have been largely achieved by improvements in supportive care measures rather than therapeutic advances. The combination of daunorubicin and cytarabine has remained standard undergoing intensive induction–consolidation treatment. In less fit older patients, low-dose is equivalent, although hypomethylating agent azacitidine may be challenging current practice. Enhanced understanding disease pathogenesis therapy...
A 63-year-old male carpenter presented with diarrhoea after returning from a holiday in Egypt no other abdominal features. Physical examination showed generalised lymphadenopathy and splenomegaly. Blood tests including inflammatory markers were within normal limits. Microbiological stool sample analysis was unremarkable. Endoscopies of the large bowel patchy inflammation rectum to hepatic flexure multiple tiny polyps. Histology revealed lymphocytic infiltrate suggestive lymphomatous...
<p class="BodyText1">Hydroxybenzoate (HB) compounds have shown to modulate the morphology in human fibrosarcoma HT-1080 cells. The changes cells showed marker signs of apoptosis, which included condensation nucleus, cell round, blebbing and formation apoptotic bodies. different stages apoptosis were assessed microscopically using staining immunohistochemical techniques, as well scanning electron microscopy. In addition, HB increased expression caspase-3, is closely associated with...