A5025857162- Wound Healing and Treatments
- Metal Alloys Wear and Properties
- Surface Treatment and Coatings
- Bee Products Chemical Analysis
- Advanced materials and composites
- Advancements in Materials Engineering
- Laser Applications in Dentistry and Medicine
- Galectins and Cancer Biology
- Metal and Thin Film Mechanics
- Pomegranate: compositions and health benefits
- Tendon Structure and Treatment
- Technical Engine Diagnostics and Monitoring
- Phytochemicals and Antioxidant Activities
- Mechanical and Thermal Properties Analysis
- Polysaccharides and Plant Cell Walls
- Surgical Sutures and Adhesives
- Tribology and Wear Analysis
- Dermatologic Treatments and Research
- Material Properties and Applications
- Minimally Invasive Surgical Techniques
- Advanced Machining and Optimization Techniques
- Clinical practice guidelines implementation
- Phytochemical compounds biological activities
- Signaling Pathways in Disease
- Therapeutic Uses of Natural Elements
University of Pavol Jozef Šafárik
2009-2025
Univerzitná Nemocnica Louisa Pasteura
2018-2024
Slovak University of Agriculture in Nitra
2010-2023
The introduction of the open abdomen technique for laparostomies has presented new problems, including method temporary coverage and primary delayed closure laparostomy. Numerous techniques a laparostomy have been described in literature, but with colostomy present is more technically challenging situation. combination negative pressure wound therapy mesh-mediated fascial traction now considered choice. This paper presents modification techniques, by which can be easily quickly achieved...
Galectins are a family of carbohydrate-binding proteins that modulate inflammation and immunity. This functional versatility prompted us to perform histochemical study their occurrence during wound healing using rat skin as an in vivo model. Wound is dynamic process exhibits three basic phases: inflammation, proliferation, maturation. In this antibodies against keratins-10 -14, wide-spectrum cytokeratin, vimentin, fibronectin, non-cross-reactive galectins-1, -2, -3 were applied frozen...
The aim of present study was to evaluate whether low-level laser therapy (LLLT) can reverse the impaired wound healing process in diabetic rats.Impaired patients represents a major health problem. Recent studies have indicated that LLLT may improve rats, but optimal treatment parameters are still unknown.Male Sprague-Dawley rats (n=21) were randomly divided into three groups: healthy control group, sham-treated and LLLT-treated group. Diabetes mellitus then induced by streptozotocin...
The aim of our study was to compare the effects different power densities LLLT at 635 and 670 nm achieving a daily dose 5 J/cm(2) on wound tensile strength (TS) in rats.Optimal parameters low-level laser therapy (LLLT) are still unknown.Under general anesthesia, one full-thickness skin incision performed back each rat (n = 40) immediately closed using an intradermal running suture. Rats were separated into five groups depending treatment parameters: (1) sham irradiated control group (SIC);...
Reactive oxygen species (ROS) are highly considered in the ethiopathogenesis of different pathological conditions because they may cause significant damage to cells and tissues. In this paper, we focused on potential antioxidant properties two medical plants such as Agrimonia eupatoria L. Cynara cardunculus Both have previously been studied for their pharmacological activities, especially hepatoprotective hypoglycemic activities. It has suggested, that effects related polyphenols, which...
Although the exact underlying mechanisms are still unknown, Plantago lanceolata L. (PL) water extracts frequently used to stimulate wound healing and drain abscesses. Therefore, in this experimental study effect of PL extract on skin was studied Sprague-Dawley rats.Two excisional one incisional wounds were performed back each rat. Wounds treated for three consecutive days with two different concentrations aqueous PL. Rats sacrificed 7, 14, 21 after surgery. Samples processed macroscopic...
Estrogen deprivation is considered responsible for many age-related processes, including poor wound healing. Guided by previous observations that estradiol accelerates re‑epithelialization through estrogen receptor (ER)‑β, in the present study, we examined whether selective ER agonists [4,4',4''-(4-propyl [1H] pyrazole-1,3,5-triyl)‑trisphenol (PPT), ER‑α agonist; 2,3-bis(4-hydroxyphenyl)-propionitrile (DPN), ER‑β agonist] affect expression of basic proliferation and differentiation markers...
Previously, we found that treatment of cutaneous wounds with Atropa belladonna L. (AB) revealed shortened process acute inflammation as well increased tensile strength and collagen deposition in healing skin (Gál et al. 2009). To better understand AB effect on wound male Sprague-Dawley rats were submitted to one round full thickness the back. In two experimental groups different concentrations extract daily applied whereas control group remained untreated. For histological evaluation samples...
The ability of horse chestnut extract (HCE) to induce contraction force in fibroblasts, a process with remarkable significance skin repair, motivated us evaluate its wound healing potential series experiments. In the vitro study human dermal fibroblasts form myofibroblast-like cells was evaluated at protein level (Western blot and immunofluorescence). vivo conducted on male Sprague-Dawley rats inflicted wounds (one open circular one sutured incision) their backs. Rats were topically treated...
Understanding the molecular and cellular processes in skin wound healing can pave way for devising innovative concepts by turning identified natural effectors into therapeutic tools. Based on concept of broad‑scale engagement members family galactoside‑binding lectins (galectins) pathophysiological processes, such as cancer or tissue repair/regeneration, present study investigated potential galectins‑1 (Gal‑1) ‑3 (Gal‑3) healing. Human dermal fibroblasts, which are key cells involved...
This article deals with possibilities of an application controlled diffusion processes in remelting steel surface layers electric arc non-consumable electrode, the environment enriched by boron, aim to achieve improved wear resistance.In design experiment, there was formulated assumption that dissociation and ionisation can be achieved, allowing initiation layer remelted.Conditions for creation hard stable structures required properties should obtained enrichment layers.The grades 16MnCr5...
Selective estrogen receptor modulators (SERMs) have been developed to achieve beneficial effects of estrogens while minimizing their side effects. In this context, we decided evaluate the protective effect genistein, a natural SERM, on skin flap viability in rats and series vitro experiments endothelial cells (migration, proliferation, antioxidant properties, gene expression profiling following genistein treatment). Our results showed that administration increased viability, but importantly,...
We have previously shown that the water extract of Agrimonia eupatoria L. (AE) is a valuable source polyphenols with excellent antioxidant properties and has clinical potential for prevention and/or adjuvant therapy cardiovascular complications associated diabetes. Inspired by our published data, in present study we examined whether AE improves skin wound healing series vitro vivo experiments.In detail, investigated ability to induce fibroblast myofibroblast conversion, extracellular matrix...
BACKGROUND: The in vivo recovery and half‐life of intermediate‐purity, vapor‐heated factor VII (FVII) concentrate were determined patients having a congenital deficiency for FVII according to the 1991 guidelines International Society Thrombosis Haemostasis. STUDY DESIGN AND METHODS: A total 11 received single infusion concentrate. Blood was drawn before 15 30 minutes 1, 2, 4, 8, 12, 24 hours after. Recoveries calculated from highest activity first four blood samples after infusion. two‐phase...
In presented paper we described studies of resistance selected material in abrasive wear tests. A surface tested materials was remelted with TIG method a compound gases argon and B4C. Analysing tests results found out, that the most resistant sample steel 11 373 12 050. The process remelting by using electrical arc gas atmosphere generates conditions allow creation steady structures mechanical properties higher resistance. Materials 050 were used for verifying those facts comparison to etalon 014.
The principle of vibrodiagnostics lies in the appropriate measuring and analysis mechanical vibrations machinery constructions industrial laboratory environment.The aim this paper is to perform diagnostic measurements on most essential parts (spindles) devices Semico VCM 1000. Measurements were carried out by means portable vibrodiagnostic device Adash A4900 vibrio M. Vibrodiagnostic itself was realized as a walk-monitoring state according corresponding technical standard ISO 10816-3:2009,...
This article deals with studying the relationships among chemical composition, microstructure and properties (hardness, micro-hardness, wear resistance) of powder additives based on NiCrBSi after their deposition. Tested materials reached a relatively wide range hardness deposition, which corresponds to composition microstructure. The abrasive resistance was tested an emery cloth. results indicate that both depend especially content carbon chromium. Microstructural analysis indicates...
For the renovation and/or improvement of surface properties machine elements, hard facing is often used. Hard structures obtained in layers or by heat treatment achieve a hardness up to 68 (HRC) even more. The grinding these surfaces demands use processing fluids and causes sometimes changes structure. turning can replace when certain requirements are fulfilled, particularly tough machining system. deposits two weld-on materials on sample steel grade S235JRG1 have been turned using cemented...
The subject-matter of this article is using diffusion processes to obtain chemically stable compounds with a low reactivity and higher mechanical properties in material surface layer. These were implemented by remelting the given arc process TIG welding method. Nitrogen was used as an alloying element experiments. experiment assumed that dissociation ionization gases, enabling layer remelted steel, will be achieved means electric arc. Conditions for formation hard structures required should...
The most common way of renovation the working parts agricultural machinery is surfacing by hardfacing coated electrodes and piped wires. Another to prolong life chemical heat treatment material surface nitriding. By nitriding, high hardness obtained affected a suitable environment raised temperature. This paper deals with possibilities increasing lifetime functional area ploughshare wire reshaping layer in an argon nitrogen using welding rectifier Tungsten Inert GAS method, validation these...
The study deals with the effect of cutting parameters such as speed, feed and cooling on quality machined surfaces in process hole drilling for sliding bearings used agricultural technique. This has been studied various metals copper, brass, dural leaded bronze, which are commonly their friction knots moving parts machinery. results suggest use design collection parts, scything strips, well lifting equipment technique, where particular linear rotary movements slow, appropriate procedures.
Agrimonia eupatoria L. (AE) has a rich tradition of use in wound healing improvement across various cultures worldwide. In previous studies, we revealed that water extract possesses polyphenolic composition, displaying remarkable antioxidant properties. Our investigations also demonstrated lipophosphonoxin (LPPO) exhibited antibacterial efficacy vitro while preserving the proliferation and differentiation fibroblasts keratinocytes. Building upon our prior findings, this study, intended to...