A5100772715- Neuroinflammation and Neurodegeneration Mechanisms
- Cancer-related molecular mechanisms research
- Immune cells in cancer
- Extracellular vesicles in disease
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Epigenetics and DNA Methylation
- Immune Response and Inflammation
- Glioma Diagnosis and Treatment
- Bioinformatics and Genomic Networks
- Cerebrovascular and genetic disorders
- Hormonal Regulation and Hypertension
- Metabolism and Genetic Disorders
- Ion Transport and Channel Regulation
- ATP Synthase and ATPases Research
- Signaling Pathways in Disease
- Mitochondrial Function and Pathology
- Cardiac Ischemia and Reperfusion
- Peroxisome Proliferator-Activated Receptors
- Chemokine receptors and signaling
- Immune Cell Function and Interaction
- RNA modifications and cancer
- Mycobacterium research and diagnosis
- RNA regulation and disease
- Pancreatic function and diabetes
Huazhong University of Science and Technology
2020-2025
Tongji Hospital
2020-2025
Charité - Universitätsmedizin Berlin
2020-2022
Max Delbrück Center
2019-2022
Case Western Reserve University
2020-2021
University School
2021
Orthopädische Universitätsklinik
2020
Capital Medical University
2011-2017
Beijing Anzhen Hospital
2011-2017
Shanghai Children's Hospital
2012
Highlights•let-7 miRNAs act as Toll-like receptor (TLR) 7 signaling molecules in glioma•Extracellular let-7 differentially modulate microglial biology•The sequence motif UUGU is responsible for let-7-induced activation•Select attenuate glioma growth by directly activating TLR7SummaryMicroglia express receptors (TLRs) that sense pathogen- and host-derived factors, including single-stranded RNA. In the brain, microRNA (miRNA) family members are abundantly expressed, some have recently been...
The normal expression of myocardial mitochondrial enzymes is essential to maintain the cardiac energy reserve and facilitate responses stress, but molecular mechanisms enzyme have been elusive. Here we report that congestive heart failure associated with a significant decrease estrogen-related receptor-α (ERRα), not peroxisome proliferator-activated receptor-γ coactivator 1α, in human samples. In addition, chronic pressure overload mice caused ERRα was significantly correlated degree left...
Astrocyte-microglial interaction plays a crucial role in brain injury-associated neuroinflammation. Our previous data illustrated that astrocytes secrete microRNA, leading to anti-inflammatory effects on microglia. Long non-coding RNAs participate neuroinflammation regulation after traumatic injury. However, the effect of microglial phenotype via long and underlying molecular mechanisms remain elusive. We used RNA sequencing murine found exosomal 4933431K23Rik attenuated injury-induced...
Factors released from glioma-associated microglia/macrophages (GAMs) play a crucial role in glioblastoma multiforme (GBM) progression. Here, we study the importance of CCL18, cytokine expressed human but not rodent GAMs, as modulator glioma growth. Since CCL18 signaling could be studied classical mouse models, developed an approach by transplanting induced pluripotent stem cell-derived microglia and cells into brain slices depleted their intrinsic microglia. We observe that promotes cell...
Neuroblastoma (NB) is a type of tumor usually found in children under 5 years age, which originates from lesions the nervous system and has fast growth early transformation characteristics. Similar to other cancer types, some typical suppressor genes (TSGs), such as P53 CHD5 are silenced NB because high methylation at promoter zones. In present study, our results showed that genistein, an element soy, epigenetic modifier able decrease hypermethylation levels CHD5, enhances expression well...
In murine experimental glioma models, TLR3 or TLR9 activation of microglial/macrophages has been shown to impair growth, which could, however, not verified in recent clinical trials. We therefore tested whether combined and microglia/macrophages would have a synergistic effect. Indeed, TLR3/TLR9 augmented the suppression growth organotypic brain slices from male mice microglia-dependent fashion, this depended on interferon β release phagocytic tumor clearance. Combined stimulation also...
Abstract Histamine is a monoaminergic neurotransmitter which released within the entire brain from ascending axons originating in tuberomammillary nucleus sleep state‐dependent fashion. Besides modulation of neuronal firing patterns, histamine levels are also thought to modulate functions glial cells. Microglia innate immune cells and professional phagocytes central nervous system, was previously shown have multiple effects on microglial health disease. Isolated microglia respond only...
Abstract Glial cell line‐derived neurotrophic factor (GDNF) is released by glioma cells and promotes tumor growth. We have previously found that GDNF from the a chemoattractant for microglial cells, immune of central nervous system. Here we show increases matrix metalloproteinase (MMP) 9 MMP14 expression in cultured mixed sexes neonatal mice. The GDNF‐induced MMP9 upregulation mediated family receptor alpha 1 receptors dependent on p38 mitogen‐activated protein kinase signaling. In...
Several pediatric mitochondrial disorders, including Leigh syndrome (LS), impact (mt) genetics, development, and metabolism, leading to complex pathologies energy failure. The extent which pathogenic mtDNA variants regulate disease severity in LS is currently not well understood. To better understand this relationship, we computed a glycolytic bioenergetics health index (BHI) for measuring dysfunction patient fibroblast cells harboring varying percentages of mutant (T8993G, T9185C)...
Necroptosis is closely related to the occurrence and development of tumors, including glioma. A growing number studies indicate that targeting necroptosis could be an effective treatment strategy against cancer. Long non-coding RNA (lncRNA) also believed play a pivotal role in tumor epigenetics. Therefore, it necessary identify functions necroptosis-related lncRNAs In this study, transcriptome clinical characteristic data glioma patients from The Cancer Genome Atlas (TCGA) Chinese Glioma...
Objective To explore the effect of exosomes secreted by human umbilical mesenchymal stem cells (hUMSCs)on high glucose-induced vascular endothelial (hUVECs). Methods hUMSCs and hUVECs were primary cultured enzyme digestion method surface markers P3 generation was detected using flow cytometry (FCM). The serum-free medium hUMSCs collected to extract then observed their ultrastructure under an electron microscope FCM again.The divided into 4 groups in vitro: glucose (20 mmol/L) group,...
Abstract BACKGROUND Glioblastoma multiforme is a highly malignant brain tumor with devastating prognosis. Resection followed by radio-chemotherapy leads to an overall survival of only 15 months. Up 40% the mass consist tumor-associated microglia and macrophages (TAMs). These cells were shown promote growth invasiveness in many murine glioma models. The interaction between TAMs crucial for progression includes several known pathways. Still, models partially mirror human microenvironment....