A5066562605- Cardiac electrophysiology and arrhythmias
- Ion channel regulation and function
- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- Cardiovascular Function and Risk Factors
- Receptor Mechanisms and Signaling
- Plant-Microbe Interactions and Immunity
- Plant Pathogens and Fungal Diseases
- Plant Pathogens and Resistance
- stochastic dynamics and bifurcation
- Low-power high-performance VLSI design
- ECG Monitoring and Analysis
- Catalytic Processes in Materials Science
- Zeolite Catalysis and Synthesis
- Electrostatic Discharge in Electronics
- transportation and logistics systems
- Fatty Acid Research and Health
- Plant pathogens and resistance mechanisms
- Pain Management and Treatment
- Cardiac Ischemia and Reperfusion
- Polymer Foaming and Composites
- Diabetes Treatment and Management
- Fault Detection and Control Systems
- Neurological disorders and treatments
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
Karlsruhe Institute of Technology
2024-2025
Masaryk University
2016-2018
University of Exeter
2013-2017
University of Bologna
2012-2014
University of Chemistry and Technology, Prague
2006
Abstract Regular activation of the heart originates from cyclic spontaneous depolarisations sinoatrial node cells (SANCs). Variations in electrolyte levels, commonly observed haemodialysis (HD) patients, and autonomic nervous system (ANS) profoundly affect SANC function. Thus we investigated effects hypocalcaemia sympathetic stimulation on beating rate (BR). The β‐adrenergic receptor (β‐AR) signalling cascade, as described by Behar et al., was incorporated into models Severi al. (rabbit)...
Polyunsaturated fatty n-3 acids (PUFAs) have been reported to exhibit antiarrhythmic properties. However, the mechanisms of action remain unclear. We studied electrophysiological effects eicosapentaenoic acid (EPA) and docosahexaenoic (DHA) on IKs, expression location Kv7.1 KCNE1. Experiments were performed using patch-clamp, western blot, sucrose gradient techniques in COS7 cells transfected with Kv7.1/KCNE1 channels. Acute perfusion both PUFAs increased current, this effect being greater...
Atrial anti-arrhythmic effects of β-adrenoceptor antagonists (β-blockers) may involve both a suppression pro-arrhythmic catecholamines, and an adaptational electrophysiological response to chronic β-blocker use; so-called ‘pharmacological remodelling’. In human atrium, such remodelling decreases the transient outward (Ito) inward rectifier (IK1) K+ currents, increases cellular action potential duration (APD) effective refractory period (ERP). However, consequences these changes on mechanisms...
The BeatBox simulation environment combines flexible script language user interface with the robust computational tools, in order to setup cardiac electrophysiology in-silico experiments without re-coding at low-level, so that cell excitation, tissue/anatomy models, stimulation protocols may be included into a script, and run either sequentially or parallel (MPI) re-compilation. is free software written C on Unix-based platform. It provides whole spectrum of multi scale tissue modelling from...
The modern Markov chain models of ionic channels in excitable membranes are numerically stiff. popular numerical methods for these require very small time steps to ensure stability. Our objective is formulate and test two addressing this issue, so that the timestep can be chosen based on accuracy rather than Both proposed extend Rush-Larsen technique, which was originally developed Hogdkin-Huxley type gate models. One method, "matrix Rush-Larsen" (MRL) uses a matrix reformulation scheme,...
Background and Aims Current strategies for increased crop protection of susceptible tomato plants against pathogen infections include treatment with synthetic chemicals, application natural pathogen-derived compounds or transfer resistance genes from wild species within breeding programmes. In this study, a series 45 potentially involved in defence mechanisms was retrieved the genome sequence inbred reference cultivar Solanum lycopersicum 'Heinz 1706'. The aim study to analyse expression...
Abstract Regular activation of the heart originates from cyclic spontaneous depolarisations sinoatrial node cells (SANC). Variations in electrolyte levels, commonly observed haemodialysis (HD) patients, and autonomic nervous system (ANS) profoundly affect SANC function. Thus, we investigated effects hypocalcaemia sympathetic stimulation on beating rate (BR). The β-adrenergic (β-AR) signalling cascade, as described by Behar et al., was incorporated into models Severi al. (rabbit) Fabbri...
We explore the feasibility of using fast-slow asymptotics to eliminate computational stiffness discrete-state, continuous-time deterministic Markov chain models ionic channels underlying cardiac excitability. focus on a model fast sodium current, and investigate its asymptotic behaviour with respect small parameters identified in different ways.
We evaluate the accuracy and efficiency of an exponential integrator method applied to a cardiac excitation model with numerically stiff Markov chain (MC) description ionic channels, namely Ryanodine receptor (RyR) L-type calcium channel ICa(L). If solved by explicit methods such as forward Euler (FE), stability constraints for these MC models require very small time steps.
The modern Markov chain models of ionic channels in excitable membranes are numerically stiff. popular numerical methods for these require very small time steps to ensure stability. Our objective is formulate and test two addressing this issue, so that the timestep can be chosen based on accuracy rather than Both proposed extend Rush-Larsen technique, which was originally developed Hogdkin-Huxley type gate models. One method, "Matrix Rush-Larsen" (MRL) uses a matrix reformulation scheme,...