We investigated whether standardized edible bird’s nest extract (BNE-PK) can prevent ultraviolet B (UVB) irradiation-mediated oxidative stress and photoaging in the skin using vitro vivo models. BNE-PK increased hydration by hyaluronic acid synthesis activation of ceramide synthase UVB-irradiated hairless mice HaCaT cells. Furthermore, suppressed melanogenesis down-regulation cAMP/PKA/CREB/MITF/TRP-1/TRP-2/tyrosinase pathway 3-isobutyl-1-methylxanthine (IBMX)-treated B16F10 In mice,...

This study was carried out to investigate the effects of policosanol on high-fat and high-cholesterol diet-induced hypercholesterolemic rats provide strong evidence in support its hypocholesterolemic effect. The showed elevations liver weight, total triglycerides, cholesterol, low-density lipoprotein (LDL) cholesterol serum; however, supplementation reduced these markers significantly. In addition, we found that stimulated an increase fecal bile acid contents deactivated...

In this study, we investigated the protective effects of low-molecular-weight fish collagen from tilapia against melanogenesis in melanocytes, ultraviolet B (UVB)-irradiated Hs27 skin fibroblasts, and hairless mice. We observed production-related pathways UVB-irradiated fibroblasts mice, melanogenesis-related melanocyte The were activated addition, UVB exposure stimulated melanocytes However, treatment with significantly increased messenger RNA expressions factors decreased production...

The non-saponin fraction of Korean Red Ginseng has been reported to have many biological activities. However, the effect this on anti-diabetic activity not elucidated in detail. In study, we investigated effects KGC05P0, a Ginseng, vitro and vivo. We measured inhibition commercially obtained α-glucosidase α-amylase activities glucose uptake transport rate Caco-2 cells. C57BL/6J mice C57BLKS/Jdb/db (diabetic) were fed diets with or without KGC05P0 for eight weeks. To perform experiments,...

There are a number of factors that cause immune system disruption, including infection caused by foreign antigens and decreased immunity due to excessive exercise, public interest in improving is growing. In this study, we investigate the immunomodulatory effects Echinacea purpurea (E) extract C57BL/6N mice were exposed forced swimming exercise. six experimental groups as follows: wild-type, exercise control, positive control (red ginseng, 300 mg/kg), E (50, 100, 200 mg/kg b.w.) groups. The...

Overexposure to ultraviolet B (UVB) irradiation induces photoaging that is characterized by the formation of wrinkles and loss skin elasticity. To understand mechanism action probiotics prebiotics in protection against photoaging, we investigated effects dietary supplementation with probiotic, Bifidobacterium longum, prebiotic, galacto-oligosaccharide, on UVB-induced hairless mice. We measured short chain fatty acid (SCFA) levels, antioxidant enzyme activity, inflammatory signaling protein...

We evaluated the effect of artichoke leaf extract (ALE) on livers mice with non-alcoholic fatty liver disease (NAFLD) induced by high-fat/high-fructose diet and H2O2-treated HepG2 cells, as well mechanism underlying its hepatoprotective effects. Supplementation ALE suppressed NAFLD-induced increases in serum lipids, bilirubin, gamma-glutamyl transferase, aspartate transaminase (AST), alanine aminotransferase. In addition, we observed that supplementation attenuated antioxidant enzyme...

The present study aimed to investigate the antihypercholesterolemic effects of krill oil supplementation in high-cholesterol diet-induced hypercholesterolemic rats, and mechanisms underlying these effects. Rats were divided into five groups: normal control, control (high-cholesterol diet), 100 mg/kg b.w. diet with Krill b.w.), 200 b.w.). After 12 weeks, rats sacrificed observe on cholesterol synthesis excretion. We found that suppressed total triglycerides, cholesterol, LDL-cholesterol...

For this research article, we investigated the protective effects of enzyme-treated caviar powder extract (CV) in ultraviolet B (UVB)-irradiated hairless mice and keratinocytes by confirming moisturizing-related factors elasticity-related factors. UVB irradiation induced wrinkle formation, dehydration, oxidative stress, inflammation dorsal skin mice; however, these were suppressed CV-supplemented groups UVB-irradiated mice. Furthermore, keratinocytes, CV treatment increased antioxidant...

Consistent ultraviolet B (UVB) radiation exposure results in dry skin, wrinkles, and melanogenesis. In this study, we investigated whether fish collagen peptide (NaticolⓇ) could inhibit photoaging oxidative stress skin exposed to UVB using cell animal models. We measured the hydration, histological observations, antioxidant activities, moisturizing-related factors, synthesis-related melanogenesis-related factors cells enzyme-linked immunosorbent assay, real-time polymerase chain reaction,...

Hyperuricemia, abnormally excess accumulation of uric acid, is caused by an imbalance between the production and excretion acid a major cause gout. We compared effects extracts from Chrysanthemum indicum L. (Ci) Cornus officinalis Siebold Zucc. (Co) on hyperuricemia, both individually in combination (FSU-CC), using hypoxanthine-treated human liver cancer (HepG2) cells, primary mouse renal proximal tubule potassium oxonate induced hyperuricemic mice. The Ci contained 7.62 mg/g luteolin 0...

We investigated the effects of GT collagen (Geltech low-molecular-weight fish collagen, FC) on skin moisturization in ultraviolet B (UVB)-irradiated HaCaT cells and SKH-I hairless mice. In vitro, we measured expression mRNA genes proteins related to moisturizing mechanism, hyaluronic acid concentrations, sphingomyelin concentrations. As a result, FC increased LCB1, DEGS1, elastin, UGTrel7, GlcNAc UVB-irradiated cells. Also, level, protein expressions hyaluronan synthase (HAS)2 CerS4 were...

This study investigated the protective effects of glucocerebroside-containing buttermilk concentrated powder (GCBM) on oxidative stress and photoaging in ultraviolet B (UVB)-irradiated hairless mice. We measured antioxidant enzyme activities, collagen synthesis-related pathways, moisturizing-related factors dorsal skin observed that dietary supplementation with GCBM increased activity decreased pro-inflammatory cytokine expression UVB-irradiated skin. Furthermore, inhibited wrinkle formation...

The aim of this study was to examine the effects Antarctic krill oil (FJH-KO) in a rat model monosodium iodoacetate (MIA) induced osteoarthritis. effect FJH-KO on development and severity MIA-induced osteoarthritis assessed using hematoxylin eosin (H&E) staining micro-CT. expression PGE2, pro-inflammatory cytokines (IL-1β, TNF-α), arthritics related genes osteoarthritic rats response supplementation investigated real time PCR. arthritic reduced tissue damage, cartilage degeneration,...

This study investigated the protective effects of a complex Indian gooseberry and barley sprout (IB complex) on oxidative stress skin damage caused by ultraviolet B irradiation in SHK-I hairless mice. The examined impact IB hydration, wrinkle formation, melanogenesis using enzyme-linked immunosorbent assay, real-time polymerase chain reaction, western blot analysis. reduced hydration loss while also demonstrating enhanced antioxidant activities. maintained via upregulation hyaluronic acid...

Excessive and prolonged alcohol consumption can lead to a serious health condition known as alcohol-related liver disease (ARLD). This ailment represents significant worldwide challenge, affecting populations across various demographics. ARLD has multifactorial pathogenesis involving oxidative stress, inflammation, dysregulated lipid metabolism, apoptosis. In this study, we investigated the hepatoprotective effects of

UV radiation is a major factor contributing to DNA damage in skin cells, including stem cells and mesenchymal leading the depletion of these crucial cells. This study examined whether mixture Indian gooseberry barley sprout (IB) could inhibit UVB irradiation 3-isobutyl-1-methylxanthine (IBMX)-induced photoaging oxidative stress using HaCaT, Hs27, B16F10

The present research purposed to examine the gastro-protective effect of Glycine max (L.) Merr. fermented using Lactobacillus delbrueckii ssp. Rosell-187 (Gastro-AD®) on ethanol/HCl-induced gastric damage, specifically acid secretion. After oral supplementation Gastro-AD® Sprague-Dawley (SD) rats with we determined that attenuated mucosal lesion, hemorrhage and secretion induced by ethanol/HCl. In addition, observed treatment increased serum prostaglandin E2 level decreased levels...

We demonstrated the effect of a mixture containing fermented Achyranthes japonica Nakai (FS) in context monosodium iodoacetate (MIA)-induced osteoarthritis animal model. The mineralization, anabolic and catabolic factors, amount cytokines within articular cartilage rats were measured after administration MIA. found that dietary supplementation with methylsulfonylmethane (positive control) FS (FS 100 mg/kg body weight [b.w.] 300 b.w.) effectively suppressed pathological changes knee joint...

Here, we investigated the effects of Zingiber mioga extracts (FSH-ZM) on moisturization and depigmentation skin as well wrinkle formation in UVB-irradiated HRM-2 hairless mice. The mice were divided into six groups follows: normal control (NC), (C), positive 1 (PC1, L-ascorbic acid 200 mg/kg b.w.), 2 (PC2, Arbutin Z100 (FSH-ZM 100 Z200 b.w.). experiment spanned a period 6 weeks. We found that FSH-ZM led to an increase expression hyaluronan synthase 2, fibrillin-1, elastin mRNAs, showed...

The aim of this study was to investigate the effects krill oil (FJH-KO) in monoiodoacetate (MIA)-induced osteoarthritis rat models, and H2O2- or lipopolysaccharide (LPS)-treated primary chondrocytes SW982 synovial cell line. We found that 150 mg/kg b.w. FJH-KO supplementation increased running speed, stride, foot pressure MIA-induced osteoarthritic rats. In H2O2-treated line chondrocytes, treatment prevented death suppressed matrix degradation by increasing levels anabolic factors cartilage...

본 연구에서는 새싹보리 열수 추출물의 혈행 개선 효과를 알아보고자 하였다. 관련 biomarker인 세로토닌분비, 트롬복산 A₂(TxA₂) 생성, 혈소판 응집, 활성화 프로트롬보플라스틴 시간(aPTT) 및 프로트롬빈 시간(PT)을 측정한 결과, 100, 200 μg/mL의 농도로 처리 시에는 세로토닌 분비, TxA2 응집 억제, aPTT PT에 효과가 없는 것을 확인하였다. 400 분비 TxA₂ 응집을 억제시키고 aPTT를 유의적으로 지연시키는 확인하였고, 이러한 결과가 혈행을 개선하는 기능성이 있는 것으로 보인다. 따라서 추출물이 가진 천연 기능성 식품의 개발에 있어 기초자료로 활용할 수 있을 기대할 있다.

In this study, we evaluated the effects of Lactobacillus reuteri NCIMB (LRC™) supplementation on hypercholesterolemia by researching its cellular cholesterol metabolism in hypercholesterolemic rats (KHGASP-22-170) and HepG2 cell line. Rats were separated into six groups after adaptation then fed a normal control (NC), high-cholesterol diet (HC), or HC supplemented with simvastatin 15 mg/kg body weight (positive [PC]), LRC 1 × 109 colony-forming units (CFU)/rat/day, 4 CFU/rat/day, 1010...

Kimchi is a traditional Korean food, of which its constituent lactic acid bacteria have been reported to possess various physiological activities. However, few studies investigated the immunological activity these or their effect on atopic dermatitis (AD). We whether mixture 6 types strains (LBS) isolated from kimchi has an immunomodulating atopy. Mice with were orally administered LSB for 8 weeks, and skin moisture content, scratching behavior, T-and B-cell proliferation, Th1/2 cytokines,...

The aim of this study was to investigate the effects administration a mixture Humulus japonicus (MH) on longitudinal bone growth in normal Sprague Dawley (SD) rats. We measured femur and tibia length, plate area, proliferation chondrocytes, expression insulin-like factor-1 (IGF-I) IGF binding protein-3 (IGFBP-3), Janus kinase 2 (JAK2)/signal transducer activator transcription 5 (STAT5) phosphorylation after dietary MH SD rats for four weeks. nose–tail length gain increased significantly...